Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IXE

GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0005929	cellular_component	cilium
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0045121	cellular_component	membrane raft
B	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005929	cellular_component	cilium
H	0007017	biological_process	microtubule-based process
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0045121	cellular_component	membrane raft
H	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005881	cellular_component	cytoplasmic microtubule
J	0005929	cellular_component	cilium
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0045121	cellular_component	membrane raft
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0005929	cellular_component	cilium
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0045121	cellular_component	membrane raft
K	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0001764	biological_process	neuron migration
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process
R	0015630	cellular_component	microtubule cytoskeleton
R	0021987	biological_process	cerebral cortex development
R	0045171	cellular_component	intercellular bridge
R	0046872	molecular_function	metal ion binding
R	0072686	cellular_component	mitotic spindle
W	0000166	molecular_function	nucleotide binding
W	0000226	biological_process	microtubule cytoskeleton organization
W	0000278	biological_process	mitotic cell cycle
W	0001764	biological_process	neuron migration
W	0003924	molecular_function	GTPase activity
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005525	molecular_function	GTP binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005874	cellular_component	microtubule
W	0007017	biological_process	microtubule-based process
W	0015630	cellular_component	microtubule cytoskeleton
W	0021987	biological_process	cerebral cortex development
W	0045171	cellular_component	intercellular bridge
W	0046872	molecular_function	metal ion binding
W	0072686	cellular_component	mitotic spindle
Z	0000166	molecular_function	nucleotide binding
Z	0000226	biological_process	microtubule cytoskeleton organization
Z	0000278	biological_process	mitotic cell cycle
Z	0001764	biological_process	neuron migration
Z	0003924	molecular_function	GTPase activity
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005525	molecular_function	GTP binding
Z	0005737	cellular_component	cytoplasm
Z	0005856	cellular_component	cytoskeleton
Z	0005874	cellular_component	microtubule
Z	0007017	biological_process	microtubule-based process
Z	0015630	cellular_component	microtubule cytoskeleton
Z	0021987	biological_process	cerebral cortex development
Z	0045171	cellular_component	intercellular bridge
Z	0046872	molecular_function	metal ion binding
Z	0072686	cellular_component	mitotic spindle
a	0000166	molecular_function	nucleotide binding
a	0000226	biological_process	microtubule cytoskeleton organization
a	0000278	biological_process	mitotic cell cycle
a	0001764	biological_process	neuron migration
a	0003924	molecular_function	GTPase activity
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005525	molecular_function	GTP binding
a	0005737	cellular_component	cytoplasm
a	0005856	cellular_component	cytoskeleton
a	0005874	cellular_component	microtubule
a	0007017	biological_process	microtubule-based process
a	0015630	cellular_component	microtubule cytoskeleton
a	0021987	biological_process	cerebral cortex development
a	0045171	cellular_component	intercellular bridge
a	0046872	molecular_function	metal ion binding
a	0072686	cellular_component	mitotic spindle
h	0003777	molecular_function	microtubule motor activity
h	0005524	molecular_function	ATP binding
h	0007018	biological_process	microtubule-based movement
h	0008017	molecular_function	microtubule binding
l	0003777	molecular_function	microtubule motor activity
l	0005524	molecular_function	ATP binding
l	0007018	biological_process	microtubule-based movement
l	0008017	molecular_function	microtubule binding
p	0003777	molecular_function	microtubule motor activity
p	0005524	molecular_function	ATP binding
p	0007018	biological_process	microtubule-based movement
p	0008017	molecular_function	microtubule binding
q	0003777	molecular_function	microtubule motor activity
q	0005524	molecular_function	ATP binding
q	0007018	biological_process	microtubule-based movement
q	0008017	molecular_function	microtubule binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
W	GLY140-GLY146
H	GLY148-GLY154

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
W	MET1-ILE4

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. LvDLAgsAkVSktGAegAV

Chain	Residue	Details
l	LEU229-VAL247

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"16800626","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1268
Details	Domain: {"description":"Kinesin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00283","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	28
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)