Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IXE

GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003924	molecular_function	GTPase activity
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005525	molecular_function	GTP binding
a	0005737	cellular_component	cytoplasm
a	0005856	cellular_component	cytoskeleton
a	0005874	cellular_component	microtubule
a	0007010	biological_process	cytoskeleton organization
a	0007017	biological_process	microtubule-based process
a	0015630	cellular_component	microtubule cytoskeleton
a	0021987	biological_process	cerebral cortex development
a	0045171	cellular_component	intercellular bridge
a	0046872	molecular_function	metal ion binding
a	0072686	cellular_component	mitotic spindle
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0007010	biological_process	cytoskeleton organization
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0045121	cellular_component	membrane raft
B	0046872	molecular_function	metal ion binding
h	0003777	molecular_function	microtubule motor activity
h	0005524	molecular_function	ATP binding
h	0007018	biological_process	microtubule-based movement
h	0008017	molecular_function	microtubule binding
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0007010	biological_process	cytoskeleton organization
H	0007017	biological_process	microtubule-based process
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0045121	cellular_component	membrane raft
H	0046872	molecular_function	metal ion binding
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005881	cellular_component	cytoplasmic microtubule
J	0007010	biological_process	cytoskeleton organization
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0045121	cellular_component	membrane raft
J	0046872	molecular_function	metal ion binding
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0007010	biological_process	cytoskeleton organization
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0045121	cellular_component	membrane raft
K	0046872	molecular_function	metal ion binding
l	0003777	molecular_function	microtubule motor activity
l	0005524	molecular_function	ATP binding
l	0007018	biological_process	microtubule-based movement
l	0008017	molecular_function	microtubule binding
p	0003777	molecular_function	microtubule motor activity
p	0005524	molecular_function	ATP binding
p	0007018	biological_process	microtubule-based movement
p	0008017	molecular_function	microtubule binding
q	0003777	molecular_function	microtubule motor activity
q	0005524	molecular_function	ATP binding
q	0007018	biological_process	microtubule-based movement
q	0008017	molecular_function	microtubule binding
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007010	biological_process	cytoskeleton organization
R	0007017	biological_process	microtubule-based process
R	0015630	cellular_component	microtubule cytoskeleton
R	0021987	biological_process	cerebral cortex development
R	0045171	cellular_component	intercellular bridge
R	0046872	molecular_function	metal ion binding
R	0072686	cellular_component	mitotic spindle
W	0003924	molecular_function	GTPase activity
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005525	molecular_function	GTP binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005874	cellular_component	microtubule
W	0007010	biological_process	cytoskeleton organization
W	0007017	biological_process	microtubule-based process
W	0015630	cellular_component	microtubule cytoskeleton
W	0021987	biological_process	cerebral cortex development
W	0045171	cellular_component	intercellular bridge
W	0046872	molecular_function	metal ion binding
W	0072686	cellular_component	mitotic spindle
Z	0003924	molecular_function	GTPase activity
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005525	molecular_function	GTP binding
Z	0005737	cellular_component	cytoplasm
Z	0005856	cellular_component	cytoskeleton
Z	0005874	cellular_component	microtubule
Z	0007010	biological_process	cytoskeleton organization
Z	0007017	biological_process	microtubule-based process
Z	0015630	cellular_component	microtubule cytoskeleton
Z	0021987	biological_process	cerebral cortex development
Z	0045171	cellular_component	intercellular bridge
Z	0046872	molecular_function	metal ion binding
Z	0072686	cellular_component	mitotic spindle

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
H	GLY148-GLY154
W	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
W	MET1-ILE4

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. LvDLAgsAkVSktGAegAV

Chain	Residue	Details
l	LEU229-VAL247

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
l	GLY85
R	GLY142
R	THR143
R	GLY144
R	ASN204
R	ASN226
Z	GLN11
Z	SER138
Z	GLY142
Z	THR143
Z	GLY144
h	GLY85
Z	ASN204
Z	ASN226
a	GLN11
a	SER138
a	GLY142
a	THR143
a	GLY144
a	ASN204
a	ASN226
p	GLY85
q	GLY85
W	GLY144
W	ASN204
W	ASN226
R	GLN11
R	SER138

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
l	ALA2
B	GLU77
B	SER146
B	GLY150
B	THR151
B	THR185
B	ASN212
B	ASN234
J	GLN11
J	GLU77
J	SER146
h	ALA2
J	GLY150
J	THR151
J	THR185
J	ASN212
J	ASN234
K	GLN11
K	GLU77
K	SER146
K	GLY150
K	THR151
p	ALA2
K	THR185
K	ASN212
K	ASN234
q	ALA2
H	THR151
H	THR185
H	ASN212
H	ASN234
B	GLN11

site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
l	LYS213
R	SER40
h	LYS213
a	SER40
p	LYS213
q	LYS213

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
W	LYS58
R	LYS58
Z	LYS58
a	LYS58

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250\|UniProtKB:Q13885

Chain	Residue	Details
W	SER172
R	SER172
Z	SER172
a	SER172

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
W	THR285
W	THR290
R	THR285
R	THR290
Z	THR285
Z	THR290
a	THR285
a	THR290

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
W	ARG318
R	ARG318
Z	ARG318
a	ARG318

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
W	GLU438
R	GLU438
Z	GLU438
a	GLU438

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
W	LYS58
R	LYS58
Z	LYS58
a	LYS58

site_id	SWS_FT_FI10
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
W	LYS324
R	LYS324
Z	LYS324
a	LYS324

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)