Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IUF

Cryo-EM structure of Euglena gracilis super-complex I+III2+IV, composite

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1A	0016020	cellular_component	membrane
1A	0016491	molecular_function	oxidoreductase activity
1A	0042773	biological_process	ATP synthesis coupled electron transport
1A	0051536	molecular_function	iron-sulfur cluster binding
4A	0004129	molecular_function	cytochrome-c oxidase activity
4A	0009055	molecular_function	electron transfer activity
4A	0016020	cellular_component	membrane
4A	0019646	biological_process	aerobic electron transport chain
4A	0022904	biological_process	respiratory electron transport chain
A5	0022904	biological_process	respiratory electron transport chain
AB	0006633	biological_process	fatty acid biosynthetic process
AC	0006633	biological_process	fatty acid biosynthetic process
AL	0016020	cellular_component	membrane
AL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B7	0005739	cellular_component	mitochondrion
C1	0004129	molecular_function	cytochrome-c oxidase activity
C1	0005739	cellular_component	mitochondrion
C1	0005743	cellular_component	mitochondrial inner membrane
C1	0005751	cellular_component	mitochondrial respiratory chain complex IV
C1	0006119	biological_process	oxidative phosphorylation
C1	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C1	0009060	biological_process	aerobic respiration
C1	0015990	biological_process	electron transport coupled proton transport
C1	0016020	cellular_component	membrane
C1	0016491	molecular_function	oxidoreductase activity
C1	0020037	molecular_function	heme binding
C1	0046872	molecular_function	metal ion binding
C1	0070469	cellular_component	respirasome
C2	0004129	molecular_function	cytochrome-c oxidase activity
C2	0005507	molecular_function	copper ion binding
C2	0005739	cellular_component	mitochondrion
C2	0005743	cellular_component	mitochondrial inner membrane
C2	0016020	cellular_component	membrane
C2	0022900	biological_process	electron transport chain
C2	0046872	molecular_function	metal ion binding
C2	0070469	cellular_component	respirasome
C2	1902600	biological_process	proton transmembrane transport
C3	0005739	cellular_component	mitochondrion
C3	0009055	molecular_function	electron transfer activity
C3	0016020	cellular_component	membrane
E2	0004611	molecular_function	phosphoenolpyruvate carboxykinase activity
E2	0006094	biological_process	gluconeogenesis
E2	0017076	molecular_function	purine nucleotide binding
E3	0016491	molecular_function	oxidoreductase activity
E5	0016491	molecular_function	oxidoreductase activity
EB	0005507	molecular_function	copper ion binding
EB	0005758	cellular_component	mitochondrial intermembrane space
EB	0016531	molecular_function	copper chaperone activity
EC	0006633	biological_process	fatty acid biosynthetic process
FX	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
N1	0016020	cellular_component	membrane
N4	0005739	cellular_component	mitochondrion
N4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N4	0016020	cellular_component	membrane
N4	0031966	cellular_component	mitochondrial membrane
N4	0042773	biological_process	ATP synthesis coupled electron transport
N4	0070469	cellular_component	respirasome
N4	1902600	biological_process	proton transmembrane transport
N5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N5	0042773	biological_process	ATP synthesis coupled electron transport
Qa	0004222	molecular_function	metalloendopeptidase activity
Qa	0006508	biological_process	proteolysis
Qa	0046872	molecular_function	metal ion binding
QA	0004222	molecular_function	metalloendopeptidase activity
QA	0006508	biological_process	proteolysis
QA	0046872	molecular_function	metal ion binding
Qb	0005739	cellular_component	mitochondrion
Qb	0005743	cellular_component	mitochondrial inner membrane
Qb	0046872	molecular_function	metal ion binding
Qb	0070469	cellular_component	respirasome
QB	0005739	cellular_component	mitochondrion
QB	0005743	cellular_component	mitochondrial inner membrane
QB	0046872	molecular_function	metal ion binding
QB	0070469	cellular_component	respirasome
Qc	0005739	cellular_component	mitochondrion
Qc	0005743	cellular_component	mitochondrial inner membrane
Qc	0009055	molecular_function	electron transfer activity
Qc	0016020	cellular_component	membrane
Qc	0016491	molecular_function	oxidoreductase activity
Qc	0022900	biological_process	electron transport chain
Qc	0022904	biological_process	respiratory electron transport chain
Qc	0046872	molecular_function	metal ion binding
Qc	0070469	cellular_component	respirasome
QC	0005739	cellular_component	mitochondrion
QC	0005743	cellular_component	mitochondrial inner membrane
QC	0009055	molecular_function	electron transfer activity
QC	0016020	cellular_component	membrane
QC	0016491	molecular_function	oxidoreductase activity
QC	0022900	biological_process	electron transport chain
QC	0022904	biological_process	respiratory electron transport chain
QC	0046872	molecular_function	metal ion binding
QC	0070469	cellular_component	respirasome
Qd	0005739	cellular_component	mitochondrion
Qd	0005743	cellular_component	mitochondrial inner membrane
Qd	0005750	cellular_component	mitochondrial respiratory chain complex III
Qd	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Qd	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Qd	0009055	molecular_function	electron transfer activity
Qd	0020037	molecular_function	heme binding
Qd	0046872	molecular_function	metal ion binding
Qd	0070469	cellular_component	respirasome
Qd	1902600	biological_process	proton transmembrane transport
QD	0005739	cellular_component	mitochondrion
QD	0005743	cellular_component	mitochondrial inner membrane
QD	0005750	cellular_component	mitochondrial respiratory chain complex III
QD	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
QD	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
QD	0009055	molecular_function	electron transfer activity
QD	0020037	molecular_function	heme binding
QD	0046872	molecular_function	metal ion binding
QD	0070469	cellular_component	respirasome
QD	1902600	biological_process	proton transmembrane transport
Qe	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Qe	0016020	cellular_component	membrane
Qe	0051537	molecular_function	2 iron, 2 sulfur cluster binding
QE	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
QE	0016020	cellular_component	membrane
QE	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Qg	0005750	cellular_component	mitochondrial respiratory chain complex III
Qg	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
QG	0005750	cellular_component	mitochondrial respiratory chain complex III
QG	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Qk	0005739	cellular_component	mitochondrion
Qk	0005743	cellular_component	mitochondrial inner membrane
Qk	0070469	cellular_component	respirasome
QK	0005739	cellular_component	mitochondrion
QK	0005743	cellular_component	mitochondrial inner membrane
QK	0070469	cellular_component	respirasome
S2	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S2	0048038	molecular_function	quinone binding
S2	0051287	molecular_function	NAD binding
S3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S7	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S7	0048038	molecular_function	quinone binding
S7	0051536	molecular_function	iron-sulfur cluster binding
S7	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S8	0016020	cellular_component	membrane
S8	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S8	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V1	0010181	molecular_function	FMN binding
V1	0051287	molecular_function	NAD binding
V1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V2	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDVVEVVMAL

Chain	Residue	Details
AC	ASP86-LEU101
AB	ASP86-LEU101

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyviilpvfgltsliltsiihkdifgregmmyciisigvvgyfvwa..HH

Chain	Residue	Details
C1	TRP246-HIS300

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHsfalptlgikvdaipgrinnisingltqglyvgy......CselCgsgHafM

Chain	Residue	Details
C2	VAL141-MET189

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsrweteknnGvAHFLEHMnFkGT

Chain	Residue	Details
Qa	GLY57-THR80

site_id	PS00181
Number of Residues	16
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLqvr..TGSGgHhshS

Chain	Residue	Details
B2	LYS24-SER39

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiTCQlCEvTCP

Chain	Residue	Details
S8	CYS104-PRO115
S8	CYS143-PRO154

site_id	PS00503
Number of Residues	10
Details	PECTINESTERASE_2 Pectinesterase signature 2. ViGTLDIVFG

Chain	Residue	Details
S2	VAL382-GLY391

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLmEmK

Chain	Residue	Details
S2	LEU49-LYS60

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREawDMFgvffvgHpdlRrML

Chain	Residue	Details
S3	GLU159-LEU180

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PhfCYnrnlpiaGnCRmC

Chain	Residue	Details
1A	PRO75-CYS92

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
1A	CYS142-GLN154

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. VEAGGLST

Chain	Residue	Details
A6	VAL314-THR321

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSicemeCMGaCvhAP

Chain	Residue	Details
V2	ASP133-PRO151

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
QK	LEU66-ALA86
Qk	LEU66-ALA86

site_id	SWS_FT_FI2
Number of Residues	38
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
QD	LEU203-TYR222
Qd	LEU203-TYR222

site_id	SWS_FT_FI3
Number of Residues	42
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000250\|UniProtKB:P07143

Chain	Residue	Details
QD	ASN223-LYS244
Qd	ASN223-LYS244

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: covalent => ECO:0000269\|PubMed:2558110

Chain	Residue	Details
QD	CYS40
Qd	CYS40

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000250\|UniProtKB:P07143

Chain	Residue	Details
QD	HIS41
QD	MET160
Qd	HIS41
Qd	MET160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)