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8IQ1

Crystal structure of hydrogen sulfide-bound superoxide dismutase in reduced state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0000303biological_processresponse to superoxide
A0001541biological_processovarian follicle development
A0001819biological_processpositive regulation of cytokine production
A0001895biological_processretina homeostasis
A0002262biological_processmyeloid cell homeostasis
A0004784molecular_functionsuperoxide dismutase activity
A0004842molecular_functionubiquitin-protein transferase activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006879biological_processintracellular iron ion homeostasis
A0007283biological_processspermatogenesis
A0007566biological_processembryo implantation
A0007605biological_processsensory perception of sound
A0007626biological_processlocomotory behavior
A0008217biological_processregulation of blood pressure
A0008270molecular_functionzinc ion binding
A0009408biological_processresponse to heat
A0019226biological_processtransmission of nerve impulse
A0019430biological_processremoval of superoxide radicals
A0030346molecular_functionprotein phosphatase 2B binding
A0031410cellular_componentcytoplasmic vesicle
A0032287biological_processperipheral nervous system myelin maintenance
A0032839cellular_componentdendrite cytoplasm
A0032991cellular_componentprotein-containing complex
A0040014biological_processregulation of multicellular organism growth
A0042542biological_processresponse to hydrogen peroxide
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043085biological_processpositive regulation of catalytic activity
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048678biological_processresponse to axon injury
A0050665biological_processhydrogen peroxide biosynthetic process
A0051087molecular_functionprotein-folding chaperone binding
A0051881biological_processregulation of mitochondrial membrane potential
A0060047biological_processheart contraction
A0060052biological_processneurofilament cytoskeleton organization
A0060087biological_processrelaxation of vascular associated smooth muscle
A0060088biological_processauditory receptor cell stereocilium organization
A0072593biological_processreactive oxygen species metabolic process
B0000209biological_processprotein polyubiquitination
B0000303biological_processresponse to superoxide
B0001541biological_processovarian follicle development
B0001819biological_processpositive regulation of cytokine production
B0001895biological_processretina homeostasis
B0002262biological_processmyeloid cell homeostasis
B0004784molecular_functionsuperoxide dismutase activity
B0004842molecular_functionubiquitin-protein transferase activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006749biological_processglutathione metabolic process
B0006801biological_processsuperoxide metabolic process
B0006879biological_processintracellular iron ion homeostasis
B0007283biological_processspermatogenesis
B0007566biological_processembryo implantation
B0007605biological_processsensory perception of sound
B0007626biological_processlocomotory behavior
B0008217biological_processregulation of blood pressure
B0008270molecular_functionzinc ion binding
B0009408biological_processresponse to heat
B0019226biological_processtransmission of nerve impulse
B0019430biological_processremoval of superoxide radicals
B0030346molecular_functionprotein phosphatase 2B binding
B0031410cellular_componentcytoplasmic vesicle
B0032287biological_processperipheral nervous system myelin maintenance
B0032839cellular_componentdendrite cytoplasm
B0032991cellular_componentprotein-containing complex
B0040014biological_processregulation of multicellular organism growth
B0042542biological_processresponse to hydrogen peroxide
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043085biological_processpositive regulation of catalytic activity
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043410biological_processpositive regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048678biological_processresponse to axon injury
B0050665biological_processhydrogen peroxide biosynthetic process
B0051087molecular_functionprotein-folding chaperone binding
B0051881biological_processregulation of mitochondrial membrane potential
B0060047biological_processheart contraction
B0060052biological_processneurofilament cytoskeleton organization
B0060087biological_processrelaxation of vascular associated smooth muscle
B0060088biological_processauditory receptor cell stereocilium organization
B0072593biological_processreactive oxygen species metabolic process
C0000209biological_processprotein polyubiquitination
C0000303biological_processresponse to superoxide
C0001541biological_processovarian follicle development
C0001819biological_processpositive regulation of cytokine production
C0001895biological_processretina homeostasis
C0002262biological_processmyeloid cell homeostasis
C0004784molecular_functionsuperoxide dismutase activity
C0004842molecular_functionubiquitin-protein transferase activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005777cellular_componentperoxisome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006749biological_processglutathione metabolic process
C0006801biological_processsuperoxide metabolic process
C0006879biological_processintracellular iron ion homeostasis
C0007283biological_processspermatogenesis
C0007566biological_processembryo implantation
C0007605biological_processsensory perception of sound
C0007626biological_processlocomotory behavior
C0008217biological_processregulation of blood pressure
C0008270molecular_functionzinc ion binding
C0009408biological_processresponse to heat
C0019226biological_processtransmission of nerve impulse
C0019430biological_processremoval of superoxide radicals
C0030346molecular_functionprotein phosphatase 2B binding
C0031410cellular_componentcytoplasmic vesicle
C0032287biological_processperipheral nervous system myelin maintenance
C0032839cellular_componentdendrite cytoplasm
C0032991cellular_componentprotein-containing complex
C0040014biological_processregulation of multicellular organism growth
C0042542biological_processresponse to hydrogen peroxide
C0042803molecular_functionprotein homodimerization activity
C0043025cellular_componentneuronal cell body
C0043085biological_processpositive regulation of catalytic activity
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048678biological_processresponse to axon injury
C0050665biological_processhydrogen peroxide biosynthetic process
C0051087molecular_functionprotein-folding chaperone binding
C0051881biological_processregulation of mitochondrial membrane potential
C0060047biological_processheart contraction
C0060052biological_processneurofilament cytoskeleton organization
C0060087biological_processrelaxation of vascular associated smooth muscle
C0060088biological_processauditory receptor cell stereocilium organization
C0072593biological_processreactive oxygen species metabolic process
D0000209biological_processprotein polyubiquitination
D0000303biological_processresponse to superoxide
D0001541biological_processovarian follicle development
D0001819biological_processpositive regulation of cytokine production
D0001895biological_processretina homeostasis
D0002262biological_processmyeloid cell homeostasis
D0004784molecular_functionsuperoxide dismutase activity
D0004842molecular_functionubiquitin-protein transferase activity
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005777cellular_componentperoxisome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006749biological_processglutathione metabolic process
D0006801biological_processsuperoxide metabolic process
D0006879biological_processintracellular iron ion homeostasis
D0007283biological_processspermatogenesis
D0007566biological_processembryo implantation
D0007605biological_processsensory perception of sound
D0007626biological_processlocomotory behavior
D0008217biological_processregulation of blood pressure
D0008270molecular_functionzinc ion binding
D0009408biological_processresponse to heat
D0019226biological_processtransmission of nerve impulse
D0019430biological_processremoval of superoxide radicals
D0030346molecular_functionprotein phosphatase 2B binding
D0031410cellular_componentcytoplasmic vesicle
D0032287biological_processperipheral nervous system myelin maintenance
D0032839cellular_componentdendrite cytoplasm
D0032991cellular_componentprotein-containing complex
D0040014biological_processregulation of multicellular organism growth
D0042542biological_processresponse to hydrogen peroxide
D0042803molecular_functionprotein homodimerization activity
D0043025cellular_componentneuronal cell body
D0043085biological_processpositive regulation of catalytic activity
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043410biological_processpositive regulation of MAPK cascade
D0043524biological_processnegative regulation of neuron apoptotic process
D0045471biological_processresponse to ethanol
D0046716biological_processmuscle cell cellular homeostasis
D0046872molecular_functionmetal ion binding
D0048678biological_processresponse to axon injury
D0050665biological_processhydrogen peroxide biosynthetic process
D0051087molecular_functionprotein-folding chaperone binding
D0051881biological_processregulation of mitochondrial membrane potential
D0060047biological_processheart contraction
D0060052biological_processneurofilament cytoskeleton organization
D0060087biological_processrelaxation of vascular associated smooth muscle
D0060088biological_processauditory receptor cell stereocilium organization
D0072593biological_processreactive oxygen species metabolic process
E0000209biological_processprotein polyubiquitination
E0000303biological_processresponse to superoxide
E0001541biological_processovarian follicle development
E0001819biological_processpositive regulation of cytokine production
E0001895biological_processretina homeostasis
E0002262biological_processmyeloid cell homeostasis
E0004784molecular_functionsuperoxide dismutase activity
E0004842molecular_functionubiquitin-protein transferase activity
E0005507molecular_functioncopper ion binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005777cellular_componentperoxisome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006749biological_processglutathione metabolic process
E0006801biological_processsuperoxide metabolic process
E0006879biological_processintracellular iron ion homeostasis
E0007283biological_processspermatogenesis
E0007566biological_processembryo implantation
E0007605biological_processsensory perception of sound
E0007626biological_processlocomotory behavior
E0008217biological_processregulation of blood pressure
E0008270molecular_functionzinc ion binding
E0009408biological_processresponse to heat
E0019226biological_processtransmission of nerve impulse
E0019430biological_processremoval of superoxide radicals
E0030346molecular_functionprotein phosphatase 2B binding
E0031410cellular_componentcytoplasmic vesicle
E0032287biological_processperipheral nervous system myelin maintenance
E0032839cellular_componentdendrite cytoplasm
E0032991cellular_componentprotein-containing complex
E0040014biological_processregulation of multicellular organism growth
E0042542biological_processresponse to hydrogen peroxide
E0042803molecular_functionprotein homodimerization activity
E0043025cellular_componentneuronal cell body
E0043085biological_processpositive regulation of catalytic activity
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0043410biological_processpositive regulation of MAPK cascade
E0043524biological_processnegative regulation of neuron apoptotic process
E0045471biological_processresponse to ethanol
E0046716biological_processmuscle cell cellular homeostasis
E0046872molecular_functionmetal ion binding
E0048678biological_processresponse to axon injury
E0050665biological_processhydrogen peroxide biosynthetic process
E0051087molecular_functionprotein-folding chaperone binding
E0051881biological_processregulation of mitochondrial membrane potential
E0060047biological_processheart contraction
E0060052biological_processneurofilament cytoskeleton organization
E0060087biological_processrelaxation of vascular associated smooth muscle
E0060088biological_processauditory receptor cell stereocilium organization
E0072593biological_processreactive oxygen species metabolic process
F0000209biological_processprotein polyubiquitination
F0000303biological_processresponse to superoxide
F0001541biological_processovarian follicle development
F0001819biological_processpositive regulation of cytokine production
F0001895biological_processretina homeostasis
F0002262biological_processmyeloid cell homeostasis
F0004784molecular_functionsuperoxide dismutase activity
F0004842molecular_functionubiquitin-protein transferase activity
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005777cellular_componentperoxisome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006749biological_processglutathione metabolic process
F0006801biological_processsuperoxide metabolic process
F0006879biological_processintracellular iron ion homeostasis
F0007283biological_processspermatogenesis
F0007566biological_processembryo implantation
F0007605biological_processsensory perception of sound
F0007626biological_processlocomotory behavior
F0008217biological_processregulation of blood pressure
F0008270molecular_functionzinc ion binding
F0009408biological_processresponse to heat
F0019226biological_processtransmission of nerve impulse
F0019430biological_processremoval of superoxide radicals
F0030346molecular_functionprotein phosphatase 2B binding
F0031410cellular_componentcytoplasmic vesicle
F0032287biological_processperipheral nervous system myelin maintenance
F0032839cellular_componentdendrite cytoplasm
F0032991cellular_componentprotein-containing complex
F0040014biological_processregulation of multicellular organism growth
F0042542biological_processresponse to hydrogen peroxide
F0042803molecular_functionprotein homodimerization activity
F0043025cellular_componentneuronal cell body
F0043085biological_processpositive regulation of catalytic activity
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043410biological_processpositive regulation of MAPK cascade
F0043524biological_processnegative regulation of neuron apoptotic process
F0045471biological_processresponse to ethanol
F0046716biological_processmuscle cell cellular homeostasis
F0046872molecular_functionmetal ion binding
F0048678biological_processresponse to axon injury
F0050665biological_processhydrogen peroxide biosynthetic process
F0051087molecular_functionprotein-folding chaperone binding
F0051881biological_processregulation of mitochondrial membrane potential
F0060047biological_processheart contraction
F0060052biological_processneurofilament cytoskeleton organization
F0060087biological_processrelaxation of vascular associated smooth muscle
F0060088biological_processauditory receptor cell stereocilium organization
F0072593biological_processreactive oxygen species metabolic process
G0000209biological_processprotein polyubiquitination
G0000303biological_processresponse to superoxide
G0001541biological_processovarian follicle development
G0001819biological_processpositive regulation of cytokine production
G0001895biological_processretina homeostasis
G0002262biological_processmyeloid cell homeostasis
G0004784molecular_functionsuperoxide dismutase activity
G0004842molecular_functionubiquitin-protein transferase activity
G0005507molecular_functioncopper ion binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005777cellular_componentperoxisome
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006749biological_processglutathione metabolic process
G0006801biological_processsuperoxide metabolic process
G0006879biological_processintracellular iron ion homeostasis
G0007283biological_processspermatogenesis
G0007566biological_processembryo implantation
G0007605biological_processsensory perception of sound
G0007626biological_processlocomotory behavior
G0008217biological_processregulation of blood pressure
G0008270molecular_functionzinc ion binding
G0009408biological_processresponse to heat
G0019226biological_processtransmission of nerve impulse
G0019430biological_processremoval of superoxide radicals
G0030346molecular_functionprotein phosphatase 2B binding
G0031410cellular_componentcytoplasmic vesicle
G0032287biological_processperipheral nervous system myelin maintenance
G0032839cellular_componentdendrite cytoplasm
G0032991cellular_componentprotein-containing complex
G0040014biological_processregulation of multicellular organism growth
G0042542biological_processresponse to hydrogen peroxide
G0042803molecular_functionprotein homodimerization activity
G0043025cellular_componentneuronal cell body
G0043085biological_processpositive regulation of catalytic activity
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0043410biological_processpositive regulation of MAPK cascade
G0043524biological_processnegative regulation of neuron apoptotic process
G0045471biological_processresponse to ethanol
G0046716biological_processmuscle cell cellular homeostasis
G0046872molecular_functionmetal ion binding
G0048678biological_processresponse to axon injury
G0050665biological_processhydrogen peroxide biosynthetic process
G0051087molecular_functionprotein-folding chaperone binding
G0051881biological_processregulation of mitochondrial membrane potential
G0060047biological_processheart contraction
G0060052biological_processneurofilament cytoskeleton organization
G0060087biological_processrelaxation of vascular associated smooth muscle
G0060088biological_processauditory receptor cell stereocilium organization
G0072593biological_processreactive oxygen species metabolic process
H0000209biological_processprotein polyubiquitination
H0000303biological_processresponse to superoxide
H0001541biological_processovarian follicle development
H0001819biological_processpositive regulation of cytokine production
H0001895biological_processretina homeostasis
H0002262biological_processmyeloid cell homeostasis
H0004784molecular_functionsuperoxide dismutase activity
H0004842molecular_functionubiquitin-protein transferase activity
H0005507molecular_functioncopper ion binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005777cellular_componentperoxisome
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006749biological_processglutathione metabolic process
H0006801biological_processsuperoxide metabolic process
H0006879biological_processintracellular iron ion homeostasis
H0007283biological_processspermatogenesis
H0007566biological_processembryo implantation
H0007605biological_processsensory perception of sound
H0007626biological_processlocomotory behavior
H0008217biological_processregulation of blood pressure
H0008270molecular_functionzinc ion binding
H0009408biological_processresponse to heat
H0019226biological_processtransmission of nerve impulse
H0019430biological_processremoval of superoxide radicals
H0030346molecular_functionprotein phosphatase 2B binding
H0031410cellular_componentcytoplasmic vesicle
H0032287biological_processperipheral nervous system myelin maintenance
H0032839cellular_componentdendrite cytoplasm
H0032991cellular_componentprotein-containing complex
H0040014biological_processregulation of multicellular organism growth
H0042542biological_processresponse to hydrogen peroxide
H0042803molecular_functionprotein homodimerization activity
H0043025cellular_componentneuronal cell body
H0043085biological_processpositive regulation of catalytic activity
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0043410biological_processpositive regulation of MAPK cascade
H0043524biological_processnegative regulation of neuron apoptotic process
H0045471biological_processresponse to ethanol
H0046716biological_processmuscle cell cellular homeostasis
H0046872molecular_functionmetal ion binding
H0048678biological_processresponse to axon injury
H0050665biological_processhydrogen peroxide biosynthetic process
H0051087molecular_functionprotein-folding chaperone binding
H0051881biological_processregulation of mitochondrial membrane potential
H0060047biological_processheart contraction
H0060052biological_processneurofilament cytoskeleton organization
H0060087biological_processrelaxation of vascular associated smooth muscle
H0060088biological_processauditory receptor cell stereocilium organization
H0072593biological_processreactive oxygen species metabolic process
Functional Information from PROSITE/UniProt
site_idPS00087
Number of Residues11
DetailsSOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHQfGDnT
ChainResidueDetails
AGLY42-THR52

site_idPS00332
Number of Residues12
DetailsSOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI
ChainResidueDetails
AGLY136-ILE147

site_idPS00430
Number of Residues32
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. atkavcvlkgdgpvqgtihfeakg...........................................................................................DTVVVTGS
ChainResidueDetails
AALA1-SER32

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1055410","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12906825","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1055410","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"4279916","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues24
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P00441","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues8
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P00441","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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