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8IM3

Crystal structure of human HPPD complexed with compound a10

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006559biological_processL-phenylalanine catabolic process
A0006572biological_processtyrosine catabolic process
A0009072biological_processaromatic amino acid metabolic process
A0016020cellular_componentmembrane
A0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
A0042803molecular_functionprotein homodimerization activity
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070062cellular_componentextracellular exosome
B0000139cellular_componentGolgi membrane
B0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006559biological_processL-phenylalanine catabolic process
B0006572biological_processtyrosine catabolic process
B0009072biological_processaromatic amino acid metabolic process
B0016020cellular_componentmembrane
B0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
B0042803molecular_functionprotein homodimerization activity
B0046872molecular_functionmetal ion binding
B0051213molecular_functiondioxygenase activity
B0070062cellular_componentextracellular exosome
C0000139cellular_componentGolgi membrane
C0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006559biological_processL-phenylalanine catabolic process
C0006572biological_processtyrosine catabolic process
C0009072biological_processaromatic amino acid metabolic process
C0016020cellular_componentmembrane
C0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
C0042803molecular_functionprotein homodimerization activity
C0046872molecular_functionmetal ion binding
C0051213molecular_functiondioxygenase activity
C0070062cellular_componentextracellular exosome
D0000139cellular_componentGolgi membrane
D0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0006559biological_processL-phenylalanine catabolic process
D0006572biological_processtyrosine catabolic process
D0009072biological_processaromatic amino acid metabolic process
D0016020cellular_componentmembrane
D0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
D0042803molecular_functionprotein homodimerization activity
D0046872molecular_functionmetal ion binding
D0051213molecular_functiondioxygenase activity
D0070062cellular_componentextracellular exosome
E0000139cellular_componentGolgi membrane
E0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006559biological_processL-phenylalanine catabolic process
E0006572biological_processtyrosine catabolic process
E0009072biological_processaromatic amino acid metabolic process
E0016020cellular_componentmembrane
E0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
E0042803molecular_functionprotein homodimerization activity
E0046872molecular_functionmetal ion binding
E0051213molecular_functiondioxygenase activity
E0070062cellular_componentextracellular exosome
F0000139cellular_componentGolgi membrane
F0003868molecular_function4-hydroxyphenylpyruvate dioxygenase activity
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0006559biological_processL-phenylalanine catabolic process
F0006572biological_processtyrosine catabolic process
F0009072biological_processaromatic amino acid metabolic process
F0016020cellular_componentmembrane
F0016701molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen
F0042803molecular_functionprotein homodimerization activity
F0046872molecular_functionmetal ion binding
F0051213molecular_functiondioxygenase activity
F0070062cellular_componentextracellular exosome
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AHIS183
DHIS183
DHIS266
DGLU349
EHIS183
EHIS266
EGLU349
FHIS183
FHIS266
FGLU349
AHIS266
AGLU349
BHIS183
BHIS266
BGLU349
CHIS183
CHIS266
CGLU349

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:22814378
ChainResidueDetails
ATHR2
BTHR2
CTHR2
DTHR2
ETHR2
FTHR2

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P49429
ChainResidueDetails
ALYS132
BLYS132
CLYS132
DLYS132
ELYS132
FLYS132

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER211
BSER211
CSER211
DSER211
ESER211
FSER211

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49429
ChainResidueDetails
ASER226
ESER250
FSER226
FSER250
ASER250
BSER226
BSER250
CSER226
CSER250
DSER226
DSER250
ESER226

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PDB entries from 2024-07-24

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