8IK0

Cryo-EM structure of Stimulator of interferon genes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000421	cellular_component	autophagosome membrane
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006811	biological_process	monoatomic ion transport
A	0006914	biological_process	autophagy
A	0015252	molecular_function	proton channel activity
A	0016239	biological_process	positive regulation of macroautophagy
A	0031410	cellular_component	cytoplasmic vesicle
A	0032481	biological_process	positive regulation of type I interferon production
A	0032728	biological_process	positive regulation of interferon-beta production
A	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035438	molecular_function	cyclic-di-GMP binding
A	0042803	molecular_function	protein homodimerization activity
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051259	biological_process	protein complex oligomerization
A	0051607	biological_process	defense response to virus
A	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
A	0061709	biological_process	reticulophagy
A	0140896	biological_process	cGAS/STING signaling pathway
A	1902600	biological_process	proton transmembrane transport
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000421	cellular_component	autophagosome membrane
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0005737	cellular_component	cytoplasm
B	0005776	cellular_component	autophagosome
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006811	biological_process	monoatomic ion transport
B	0006914	biological_process	autophagy
B	0015252	molecular_function	proton channel activity
B	0016239	biological_process	positive regulation of macroautophagy
B	0031410	cellular_component	cytoplasmic vesicle
B	0032481	biological_process	positive regulation of type I interferon production
B	0032728	biological_process	positive regulation of interferon-beta production
B	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035438	molecular_function	cyclic-di-GMP binding
B	0042803	molecular_function	protein homodimerization activity
B	0045087	biological_process	innate immune response
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051259	biological_process	protein complex oligomerization
B	0051607	biological_process	defense response to virus
B	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
B	0061709	biological_process	reticulophagy
B	0140896	biological_process	cGAS/STING signaling pathway
B	1902600	biological_process	proton transmembrane transport
C	0000045	biological_process	autophagosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0000421	cellular_component	autophagosome membrane
C	0002218	biological_process	activation of innate immune response
C	0002376	biological_process	immune system process
C	0005737	cellular_component	cytoplasm
C	0005776	cellular_component	autophagosome
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006811	biological_process	monoatomic ion transport
C	0006914	biological_process	autophagy
C	0015252	molecular_function	proton channel activity
C	0016239	biological_process	positive regulation of macroautophagy
C	0031410	cellular_component	cytoplasmic vesicle
C	0032481	biological_process	positive regulation of type I interferon production
C	0032728	biological_process	positive regulation of interferon-beta production
C	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035438	molecular_function	cyclic-di-GMP binding
C	0042803	molecular_function	protein homodimerization activity
C	0045087	biological_process	innate immune response
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051259	biological_process	protein complex oligomerization
C	0051607	biological_process	defense response to virus
C	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
C	0061709	biological_process	reticulophagy
C	0140896	biological_process	cGAS/STING signaling pathway
C	1902600	biological_process	proton transmembrane transport
D	0000045	biological_process	autophagosome assembly
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0000421	cellular_component	autophagosome membrane
D	0002218	biological_process	activation of innate immune response
D	0002376	biological_process	immune system process
D	0005737	cellular_component	cytoplasm
D	0005776	cellular_component	autophagosome
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006811	biological_process	monoatomic ion transport
D	0006914	biological_process	autophagy
D	0015252	molecular_function	proton channel activity
D	0016239	biological_process	positive regulation of macroautophagy
D	0031410	cellular_component	cytoplasmic vesicle
D	0032481	biological_process	positive regulation of type I interferon production
D	0032728	biological_process	positive regulation of interferon-beta production
D	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035438	molecular_function	cyclic-di-GMP binding
D	0042803	molecular_function	protein homodimerization activity
D	0045087	biological_process	innate immune response
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051259	biological_process	protein complex oligomerization
D	0051607	biological_process	defense response to virus
D	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
D	0061709	biological_process	reticulophagy
D	0140896	biological_process	cGAS/STING signaling pathway
D	1902600	biological_process	proton transmembrane transport
E	0000045	biological_process	autophagosome assembly
E	0000139	cellular_component	Golgi membrane
E	0000166	molecular_function	nucleotide binding
E	0000421	cellular_component	autophagosome membrane
E	0002218	biological_process	activation of innate immune response
E	0002376	biological_process	immune system process
E	0005737	cellular_component	cytoplasm
E	0005776	cellular_component	autophagosome
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006811	biological_process	monoatomic ion transport
E	0006914	biological_process	autophagy
E	0015252	molecular_function	proton channel activity
E	0016239	biological_process	positive regulation of macroautophagy
E	0031410	cellular_component	cytoplasmic vesicle
E	0032481	biological_process	positive regulation of type I interferon production
E	0032728	biological_process	positive regulation of interferon-beta production
E	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035438	molecular_function	cyclic-di-GMP binding
E	0042803	molecular_function	protein homodimerization activity
E	0045087	biological_process	innate immune response
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051259	biological_process	protein complex oligomerization
E	0051607	biological_process	defense response to virus
E	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
E	0061709	biological_process	reticulophagy
E	0140896	biological_process	cGAS/STING signaling pathway
E	1902600	biological_process	proton transmembrane transport
F	0000045	biological_process	autophagosome assembly
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000421	cellular_component	autophagosome membrane
F	0002218	biological_process	activation of innate immune response
F	0002376	biological_process	immune system process
F	0005737	cellular_component	cytoplasm
F	0005776	cellular_component	autophagosome
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006811	biological_process	monoatomic ion transport
F	0006914	biological_process	autophagy
F	0015252	molecular_function	proton channel activity
F	0016239	biological_process	positive regulation of macroautophagy
F	0031410	cellular_component	cytoplasmic vesicle
F	0032481	biological_process	positive regulation of type I interferon production
F	0032728	biological_process	positive regulation of interferon-beta production
F	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0035438	molecular_function	cyclic-di-GMP binding
F	0042803	molecular_function	protein homodimerization activity
F	0045087	biological_process	innate immune response
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051259	biological_process	protein complex oligomerization
F	0051607	biological_process	defense response to virus
F	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
F	0061709	biological_process	reticulophagy
F	0140896	biological_process	cGAS/STING signaling pathway
F	1902600	biological_process	proton transmembrane transport
G	0000045	biological_process	autophagosome assembly
G	0000139	cellular_component	Golgi membrane
G	0000166	molecular_function	nucleotide binding
G	0000421	cellular_component	autophagosome membrane
G	0002218	biological_process	activation of innate immune response
G	0002376	biological_process	immune system process
G	0005737	cellular_component	cytoplasm
G	0005776	cellular_component	autophagosome
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006811	biological_process	monoatomic ion transport
G	0006914	biological_process	autophagy
G	0015252	molecular_function	proton channel activity
G	0016239	biological_process	positive regulation of macroautophagy
G	0031410	cellular_component	cytoplasmic vesicle
G	0032481	biological_process	positive regulation of type I interferon production
G	0032728	biological_process	positive regulation of interferon-beta production
G	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0035438	molecular_function	cyclic-di-GMP binding
G	0042803	molecular_function	protein homodimerization activity
G	0045087	biological_process	innate immune response
G	0046872	molecular_function	metal ion binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0051259	biological_process	protein complex oligomerization
G	0051607	biological_process	defense response to virus
G	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
G	0061709	biological_process	reticulophagy
G	0140896	biological_process	cGAS/STING signaling pathway
G	1902600	biological_process	proton transmembrane transport
H	0000045	biological_process	autophagosome assembly
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0000421	cellular_component	autophagosome membrane
H	0002218	biological_process	activation of innate immune response
H	0002376	biological_process	immune system process
H	0005737	cellular_component	cytoplasm
H	0005776	cellular_component	autophagosome
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006811	biological_process	monoatomic ion transport
H	0006914	biological_process	autophagy
H	0015252	molecular_function	proton channel activity
H	0016239	biological_process	positive regulation of macroautophagy
H	0031410	cellular_component	cytoplasmic vesicle
H	0032481	biological_process	positive regulation of type I interferon production
H	0032728	biological_process	positive regulation of interferon-beta production
H	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0035438	molecular_function	cyclic-di-GMP binding
H	0042803	molecular_function	protein homodimerization activity
H	0045087	biological_process	innate immune response
H	0046872	molecular_function	metal ion binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051259	biological_process	protein complex oligomerization
H	0051607	biological_process	defense response to virus
H	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
H	0061709	biological_process	reticulophagy
H	0140896	biological_process	cGAS/STING signaling pathway
H	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	192
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86WV6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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