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8IK0

Cryo-EM structure of Stimulator of interferon genes

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0002218biological_processactivation of innate immune response
A0005737cellular_componentcytoplasm
A0005776cellular_componentautophagosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0006914biological_processautophagy
A0015252molecular_functionproton channel activity
A0016020cellular_componentmembrane
A0016239biological_processpositive regulation of macroautophagy
A0031410cellular_componentcytoplasmic vesicle
A0032481biological_processpositive regulation of type I interferon production
A0032728biological_processpositive regulation of interferon-beta production
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035438molecular_functioncyclic-di-GMP binding
A0042803molecular_functionprotein homodimerization activity
A0045087biological_processinnate immune response
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051259biological_processprotein complex oligomerization
A0051607biological_processdefense response to virus
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061709biological_processreticulophagy
A0140896biological_processcGAS/STING signaling pathway
A1902600biological_processproton transmembrane transport
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000421cellular_componentautophagosome membrane
B0002218biological_processactivation of innate immune response
B0005737cellular_componentcytoplasm
B0005776cellular_componentautophagosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0006914biological_processautophagy
B0015252molecular_functionproton channel activity
B0016020cellular_componentmembrane
B0016239biological_processpositive regulation of macroautophagy
B0031410cellular_componentcytoplasmic vesicle
B0032481biological_processpositive regulation of type I interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035438molecular_functioncyclic-di-GMP binding
B0042803molecular_functionprotein homodimerization activity
B0045087biological_processinnate immune response
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051259biological_processprotein complex oligomerization
B0051607biological_processdefense response to virus
B0061507molecular_function2',3'-cyclic GMP-AMP binding
B0061709biological_processreticulophagy
B0140896biological_processcGAS/STING signaling pathway
B1902600biological_processproton transmembrane transport
C0000045biological_processautophagosome assembly
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000421cellular_componentautophagosome membrane
C0002218biological_processactivation of innate immune response
C0005737cellular_componentcytoplasm
C0005776cellular_componentautophagosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0006914biological_processautophagy
C0015252molecular_functionproton channel activity
C0016020cellular_componentmembrane
C0016239biological_processpositive regulation of macroautophagy
C0031410cellular_componentcytoplasmic vesicle
C0032481biological_processpositive regulation of type I interferon production
C0032728biological_processpositive regulation of interferon-beta production
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035438molecular_functioncyclic-di-GMP binding
C0042803molecular_functionprotein homodimerization activity
C0045087biological_processinnate immune response
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0051259biological_processprotein complex oligomerization
C0051607biological_processdefense response to virus
C0061507molecular_function2',3'-cyclic GMP-AMP binding
C0061709biological_processreticulophagy
C0140896biological_processcGAS/STING signaling pathway
C1902600biological_processproton transmembrane transport
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000421cellular_componentautophagosome membrane
D0002218biological_processactivation of innate immune response
D0005737cellular_componentcytoplasm
D0005776cellular_componentautophagosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0006914biological_processautophagy
D0015252molecular_functionproton channel activity
D0016020cellular_componentmembrane
D0016239biological_processpositive regulation of macroautophagy
D0031410cellular_componentcytoplasmic vesicle
D0032481biological_processpositive regulation of type I interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035438molecular_functioncyclic-di-GMP binding
D0042803molecular_functionprotein homodimerization activity
D0045087biological_processinnate immune response
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0051259biological_processprotein complex oligomerization
D0051607biological_processdefense response to virus
D0061507molecular_function2',3'-cyclic GMP-AMP binding
D0061709biological_processreticulophagy
D0140896biological_processcGAS/STING signaling pathway
D1902600biological_processproton transmembrane transport
E0000045biological_processautophagosome assembly
E0000139cellular_componentGolgi membrane
E0000166molecular_functionnucleotide binding
E0000421cellular_componentautophagosome membrane
E0002218biological_processactivation of innate immune response
E0005737cellular_componentcytoplasm
E0005776cellular_componentautophagosome
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005794cellular_componentGolgi apparatus
E0006914biological_processautophagy
E0015252molecular_functionproton channel activity
E0016020cellular_componentmembrane
E0016239biological_processpositive regulation of macroautophagy
E0031410cellular_componentcytoplasmic vesicle
E0032481biological_processpositive regulation of type I interferon production
E0032728biological_processpositive regulation of interferon-beta production
E0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0035438molecular_functioncyclic-di-GMP binding
E0042803molecular_functionprotein homodimerization activity
E0045087biological_processinnate immune response
E0046872molecular_functionmetal ion binding
E0048471cellular_componentperinuclear region of cytoplasm
E0051259biological_processprotein complex oligomerization
E0051607biological_processdefense response to virus
E0061507molecular_function2',3'-cyclic GMP-AMP binding
E0061709biological_processreticulophagy
E0140896biological_processcGAS/STING signaling pathway
E1902600biological_processproton transmembrane transport
F0000045biological_processautophagosome assembly
F0000139cellular_componentGolgi membrane
F0000166molecular_functionnucleotide binding
F0000421cellular_componentautophagosome membrane
F0002218biological_processactivation of innate immune response
F0005737cellular_componentcytoplasm
F0005776cellular_componentautophagosome
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005794cellular_componentGolgi apparatus
F0006914biological_processautophagy
F0015252molecular_functionproton channel activity
F0016020cellular_componentmembrane
F0016239biological_processpositive regulation of macroautophagy
F0031410cellular_componentcytoplasmic vesicle
F0032481biological_processpositive regulation of type I interferon production
F0032728biological_processpositive regulation of interferon-beta production
F0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
F0034220biological_processmonoatomic ion transmembrane transport
F0035438molecular_functioncyclic-di-GMP binding
F0042803molecular_functionprotein homodimerization activity
F0045087biological_processinnate immune response
F0046872molecular_functionmetal ion binding
F0048471cellular_componentperinuclear region of cytoplasm
F0051259biological_processprotein complex oligomerization
F0051607biological_processdefense response to virus
F0061507molecular_function2',3'-cyclic GMP-AMP binding
F0061709biological_processreticulophagy
F0140896biological_processcGAS/STING signaling pathway
F1902600biological_processproton transmembrane transport
G0000045biological_processautophagosome assembly
G0000139cellular_componentGolgi membrane
G0000166molecular_functionnucleotide binding
G0000421cellular_componentautophagosome membrane
G0002218biological_processactivation of innate immune response
G0005737cellular_componentcytoplasm
G0005776cellular_componentautophagosome
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005794cellular_componentGolgi apparatus
G0006914biological_processautophagy
G0015252molecular_functionproton channel activity
G0016020cellular_componentmembrane
G0016239biological_processpositive regulation of macroautophagy
G0031410cellular_componentcytoplasmic vesicle
G0032481biological_processpositive regulation of type I interferon production
G0032728biological_processpositive regulation of interferon-beta production
G0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0035438molecular_functioncyclic-di-GMP binding
G0042803molecular_functionprotein homodimerization activity
G0045087biological_processinnate immune response
G0046872molecular_functionmetal ion binding
G0048471cellular_componentperinuclear region of cytoplasm
G0051259biological_processprotein complex oligomerization
G0051607biological_processdefense response to virus
G0061507molecular_function2',3'-cyclic GMP-AMP binding
G0061709biological_processreticulophagy
G0140896biological_processcGAS/STING signaling pathway
G1902600biological_processproton transmembrane transport
H0000045biological_processautophagosome assembly
H0000139cellular_componentGolgi membrane
H0000166molecular_functionnucleotide binding
H0000421cellular_componentautophagosome membrane
H0002218biological_processactivation of innate immune response
H0005737cellular_componentcytoplasm
H0005776cellular_componentautophagosome
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0005794cellular_componentGolgi apparatus
H0006914biological_processautophagy
H0015252molecular_functionproton channel activity
H0016020cellular_componentmembrane
H0016239biological_processpositive regulation of macroautophagy
H0031410cellular_componentcytoplasmic vesicle
H0032481biological_processpositive regulation of type I interferon production
H0032728biological_processpositive regulation of interferon-beta production
H0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
H0034220biological_processmonoatomic ion transmembrane transport
H0035438molecular_functioncyclic-di-GMP binding
H0042803molecular_functionprotein homodimerization activity
H0045087biological_processinnate immune response
H0046872molecular_functionmetal ion binding
H0048471cellular_componentperinuclear region of cytoplasm
H0051259biological_processprotein complex oligomerization
H0051607biological_processdefense response to virus
H0061507molecular_function2',3'-cyclic GMP-AMP binding
H0061709biological_processreticulophagy
H0140896biological_processcGAS/STING signaling pathway
H1902600biological_processproton transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues344
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30842659
ChainResidueDetails
AMET1-ARG23
DILE76-PRO97
GMET1-ARG23
GILE76-PRO97
EMET1-ARG23
EILE76-PRO97
HMET1-ARG23
HILE76-PRO97
AILE76-PRO97
BMET1-ARG23
BILE76-PRO97
CMET1-ARG23
CILE76-PRO97
FMET1-ARG23
FILE76-PRO97
DMET1-ARG23

site_idSWS_FT_FI2
Number of Residues128
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AALA24-PHE40
BALA24-PHE40
CALA24-PHE40
FALA24-PHE40
DALA24-PHE40
GALA24-PHE40
EALA24-PHE40
HALA24-PHE40

site_idSWS_FT_FI3
Number of Residues144
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:30842659
ChainResidueDetails
ALEU41-THR50
DLEU112-SER121
GLEU41-THR50
GLEU112-SER121
ELEU41-THR50
ELEU112-SER121
HLEU41-THR50
HLEU112-SER121
ALEU112-SER121
BLEU41-THR50
BLEU112-SER121
CLEU41-THR50
CLEU112-SER121
FLEU41-THR50
FLEU112-SER121
DLEU41-THR50

site_idSWS_FT_FI4
Number of Residues192
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AARG51-GLU75
BARG51-GLU75
CARG51-GLU75
FARG51-GLU75
DARG51-GLU75
GARG51-GLU75
EARG51-GLU75
HARG51-GLU75

site_idSWS_FT_FI5
Number of Residues104
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30842659
ChainResidueDetails
AARG98-TYR111
BARG98-TYR111
CARG98-TYR111
FARG98-TYR111
DARG98-TYR111
GARG98-TYR111
EARG98-TYR111
HARG98-TYR111

site_idSWS_FT_FI6
Number of Residues136
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30842659
ChainResidueDetails
APRO122-LEU139
BPRO122-LEU139
CPRO122-LEU139
FPRO122-LEU139
DPRO122-LEU139
GPRO122-LEU139
EPRO122-LEU139
HPRO122-LEU139

site_idSWS_FT_FI7
Number of Residues32
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q86WV6
ChainResidueDetails
ASER167
CTYR172
CARG243
CSER268
FSER167
FTYR172
FARG243
FSER268
DSER167
DTYR172
DARG243
ATYR172
DSER268
GSER167
GTYR172
GARG243
GSER268
ESER167
ETYR172
EARG243
ESER268
HSER167
AARG243
HTYR172
HARG243
HSER268
ASER268
BSER167
BTYR172
BARG243
BSER268
CSER167

site_idSWS_FT_FI8
Number of Residues8
DetailsBINDING: BINDING => ECO:0007744|PDB:4LUQ
ChainResidueDetails
AGLU461
BGLU461
CGLU461
FGLU461
DGLU461
GGLU461
EGLU461
HGLU461

227344

PDB entries from 2024-11-13

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