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8IED

Cryo-EM structure of GPR156-miniGo-scFv16 complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0004965molecular_functionG protein-coupled GABA receptor activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
B0004930molecular_functionG protein-coupled receptor activity
B0004965molecular_functionG protein-coupled GABA receptor activity
B0007186biological_processG protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
C0003924molecular_functionGTPase activity
C0005525molecular_functionGTP binding
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0019001molecular_functionguanyl nucleotide binding
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
D0001750cellular_componentphotoreceptor outer segment
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
D0007265biological_processRas protein signal transduction
D0008283biological_processcell population proliferation
D0016020cellular_componentmembrane
D0030159molecular_functionsignaling receptor complex adaptor activity
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0050909biological_processsensory perception of taste
D0051020molecular_functionGTPase binding
D0060041biological_processretina development in camera-type eye
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
D0097381cellular_componentphotoreceptor disc membrane
D1903561cellular_componentextracellular vesicle
Y0005515molecular_functionprotein binding
Y0005834cellular_componentheterotrimeric G-protein complex
Y0005886cellular_componentplasma membrane
Y0007165biological_processsignal transduction
Y0007186biological_processG protein-coupled receptor signaling pathway
Y0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
Y0016020cellular_componentmembrane
Y0031681molecular_functionG-protein beta-subunit binding
Y0045202cellular_componentsynapse
Y0048144biological_processfibroblast proliferation
Y0070062cellular_componentextracellular exosome
Y0071380biological_processcellular response to prostaglandin E stimulus
Y0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00435
Number of Residues11
DetailsPEROXIDASE_1 Peroxidases proximal heme-ligand signature. DVQAVASVHTL
ChainResidueDetails
AASP409-LEU419

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
DLEU70-SER84
DILE157-ILE171
DLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
YALA2
CLYS46
CSER47
CTHR48
CTHR66
CLYS154
CPRO157
CILE209

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
YCYS68
BLEU119-LEU139
BLEU165-LEU185
BVAL223-ALA243
BLEU258-THR278
BPHE289-ILE309
ALEU87-ILE107
ALEU119-LEU139
ALEU165-LEU185
AVAL223-ALA243
ALEU258-THR278
APHE289-ILE309
BVAL48-LEU68
BLEU87-ILE107

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
YCYS68
AGLY140-GLN164
AGLY244-SER257
BALA69-ASN86
BGLY140-GLN164
BGLY244-SER257

site_idSWS_FT_FI4
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805
ChainResidueDetails
CGLY2
BASN6

site_idSWS_FT_FI5
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
CCYS3

227111

PDB entries from 2024-11-06

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