Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8IAK

Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A-N71A) complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0009058biological_processbiosynthetic process
A0030170molecular_functionpyridoxal phosphate binding
B0004758molecular_functionserine C-palmitoyltransferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0006665biological_processsphingolipid metabolic process
B0009058biological_processbiosynthetic process
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0017059cellular_componentserine palmitoyltransferase complex
B0030148biological_processsphingolipid biosynthetic process
B0030170molecular_functionpyridoxal phosphate binding
B0046512biological_processsphingosine biosynthetic process
B0046513biological_processceramide biosynthetic process
B0090156biological_processintracellular sphingolipid homeostasis
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0006666biological_process3-keto-sphinganine metabolic process
C0008047molecular_functionenzyme activator activity
C0016020cellular_componentmembrane
C0017059cellular_componentserine palmitoyltransferase complex
C0090154biological_processpositive regulation of sphingolipid biosynthetic process
C0090156biological_processintracellular sphingolipid homeostasis
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0006672biological_processceramide metabolic process
D0006986biological_processresponse to unfolded protein
D0016020cellular_componentmembrane
D0017059cellular_componentserine palmitoyltransferase complex
D0030148biological_processsphingolipid biosynthetic process
D0042802molecular_functionidentical protein binding
D0090155biological_processnegative regulation of sphingolipid biosynthetic process
D0090156biological_processintracellular sphingolipid homeostasis
E0009058biological_processbiosynthetic process
E0030170molecular_functionpyridoxal phosphate binding
F0004758molecular_functionserine C-palmitoyltransferase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0006665biological_processsphingolipid metabolic process
F0009058biological_processbiosynthetic process
F0016020cellular_componentmembrane
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0017059cellular_componentserine palmitoyltransferase complex
F0030148biological_processsphingolipid biosynthetic process
F0030170molecular_functionpyridoxal phosphate binding
F0046512biological_processsphingosine biosynthetic process
F0046513biological_processceramide biosynthetic process
F0090156biological_processintracellular sphingolipid homeostasis
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0006666biological_process3-keto-sphinganine metabolic process
G0008047molecular_functionenzyme activator activity
G0016020cellular_componentmembrane
G0017059cellular_componentserine palmitoyltransferase complex
G0090154biological_processpositive regulation of sphingolipid biosynthetic process
G0090156biological_processintracellular sphingolipid homeostasis
H0003674molecular_functionmolecular_function
H0005515molecular_functionprotein binding
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0006672biological_processceramide metabolic process
H0006986biological_processresponse to unfolded protein
H0016020cellular_componentmembrane
H0017059cellular_componentserine palmitoyltransferase complex
H0030148biological_processsphingolipid biosynthetic process
H0042802molecular_functionidentical protein binding
H0090155biological_processnegative regulation of sphingolipid biosynthetic process
H0090156biological_processintracellular sphingolipid homeostasis
Functional Information from PROSITE/UniProt
site_idPS00599
Number of Residues10
DetailsAA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TFTKSFGAAG
ChainResidueDetails
BTHR363-GLY372

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
CPHE54-ILE74
GPHE54-ILE74
DTHR199-SER216
HMET1-ARG78
HLYS125-GLU148
HTHR199-SER216

site_idSWS_FT_FI2
Number of Residues160
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
DGLY79-GLY99
DTRP104-VAL124
DTHR149-SER169
DTHR178-ILE198
HGLY79-GLY99
HTRP104-VAL124
HTHR149-SER169
HTHR178-ILE198

site_idSWS_FT_FI3
Number of Residues20
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
DSER100-LYS103
DASN170-MET177
HSER100-LYS103
HASN170-MET177

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
DSER9
DSER15
DSER22
HSER9
HSER15
HSER22

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950
ChainResidueDetails
DTHR18
HTHR18

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P53224
ChainResidueDetails
DSER29
DSER51
HSER29
HSER51

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon