Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8I9R

Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State 5S RNP

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
CA	0000027	biological_process	ribosomal large subunit assembly
CA	0003723	molecular_function	RNA binding
CA	0005634	cellular_component	nucleus
CA	0005730	cellular_component	nucleolus
CA	0006364	biological_process	rRNA processing
CA	0019843	molecular_function	rRNA binding
CA	0042254	biological_process	ribosome biogenesis
CC	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CC	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CC	0005634	cellular_component	nucleus
CC	0005654	cellular_component	nucleoplasm
CC	0005730	cellular_component	nucleolus
CC	0006364	biological_process	rRNA processing
CC	0030687	cellular_component	preribosome, large subunit precursor
CC	0042254	biological_process	ribosome biogenesis
CC	0042273	biological_process	ribosomal large subunit biogenesis
CC	0043021	molecular_function	ribonucleoprotein complex binding
CC	0070545	cellular_component	PeBoW complex
CE	0003676	molecular_function	nucleic acid binding
CE	0003689	molecular_function	DNA clamp loader activity
CE	0003723	molecular_function	RNA binding
CE	0003724	molecular_function	RNA helicase activity
CE	0004386	molecular_function	helicase activity
CE	0005524	molecular_function	ATP binding
CE	0005730	cellular_component	nucleolus
CE	0006338	biological_process	chromatin remodeling
CE	0006364	biological_process	rRNA processing
CE	0016787	molecular_function	hydrolase activity
CE	0016887	molecular_function	ATP hydrolysis activity
CE	0042254	biological_process	ribosome biogenesis
CE	0061775	molecular_function	cohesin loader activity
CE	0140584	molecular_function	chromatin extrusion motor activity
CE	0140588	biological_process	chromatin looping
CE	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
CE	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
CG	0003723	molecular_function	RNA binding
CG	0005634	cellular_component	nucleus
CG	0005730	cellular_component	nucleolus
CG	0042254	biological_process	ribosome biogenesis
CG	0042255	biological_process	ribosome assembly
CH	0005525	molecular_function	GTP binding
CH	0005634	cellular_component	nucleus
CH	0005730	cellular_component	nucleolus
CH	0042254	biological_process	ribosome biogenesis
CH	0046872	molecular_function	metal ion binding
CI	0003676	molecular_function	nucleic acid binding
CI	0003723	molecular_function	RNA binding
CI	0005730	cellular_component	nucleolus
CJ	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CJ	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CJ	0003723	molecular_function	RNA binding
CJ	0005634	cellular_component	nucleus
CJ	0005654	cellular_component	nucleoplasm
CJ	0005730	cellular_component	nucleolus
CJ	0006364	biological_process	rRNA processing
CJ	0030687	cellular_component	preribosome, large subunit precursor
CJ	0042254	biological_process	ribosome biogenesis
CJ	0042273	biological_process	ribosomal large subunit biogenesis
CJ	0043021	molecular_function	ribonucleoprotein complex binding
CJ	0070545	cellular_component	PeBoW complex
CM	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CM	0003723	molecular_function	RNA binding
CM	0003735	molecular_function	structural constituent of ribosome
CM	0005840	cellular_component	ribosome
CM	0022625	cellular_component	cytosolic large ribosomal subunit
CM	1990904	cellular_component	ribonucleoprotein complex
CN	0000054	biological_process	ribosomal subunit export from nucleus
CN	0003743	molecular_function	translation initiation factor activity
CN	0005634	cellular_component	nucleus
CN	0005730	cellular_component	nucleolus
CN	0005737	cellular_component	cytoplasm
CN	0006412	biological_process	translation
CN	0006413	biological_process	translational initiation
CN	0042254	biological_process	ribosome biogenesis
CN	0042256	biological_process	cytosolic ribosome assembly
CN	0042273	biological_process	ribosomal large subunit biogenesis
CN	0043022	molecular_function	ribosome binding
CN	0043023	molecular_function	ribosomal large subunit binding
CP	0000470	biological_process	maturation of LSU-rRNA
CP	0001510	biological_process	RNA methylation
CP	0003723	molecular_function	RNA binding
CP	0005730	cellular_component	nucleolus
CP	0006396	biological_process	RNA processing
CP	0008168	molecular_function	methyltransferase activity
CP	0008173	molecular_function	RNA methyltransferase activity
CP	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
CP	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
CP	0032259	biological_process	methylation
CP	0042254	biological_process	ribosome biogenesis
CP	0070475	biological_process	rRNA base methylation
CQ	0005730	cellular_component	nucleolus
CQ	0042273	biological_process	ribosomal large subunit biogenesis
CR	0005730	cellular_component	nucleolus
CR	0042273	biological_process	ribosomal large subunit biogenesis
CR	1990904	cellular_component	ribonucleoprotein complex
CU	0005634	cellular_component	nucleus
CU	0005730	cellular_component	nucleolus
CU	0006364	biological_process	rRNA processing
CU	0030687	cellular_component	preribosome, large subunit precursor
CU	0034399	cellular_component	nuclear periphery
CU	0042254	biological_process	ribosome biogenesis
CU	0042273	biological_process	ribosomal large subunit biogenesis
CX	0003729	molecular_function	mRNA binding
CX	0005730	cellular_component	nucleolus
CX	0008298	biological_process	intracellular mRNA localization
CX	0030687	cellular_component	preribosome, large subunit precursor
CX	0042254	biological_process	ribosome biogenesis
CX	0042273	biological_process	ribosomal large subunit biogenesis
CX	0051028	biological_process	mRNA transport
Cc	0005634	cellular_component	nucleus
Cc	0006364	biological_process	rRNA processing
Cc	0030688	cellular_component	preribosome, small subunit precursor
Cd	0000460	biological_process	maturation of 5.8S rRNA
Cd	0000470	biological_process	maturation of LSU-rRNA
Cd	0005730	cellular_component	nucleolus
Cd	0006364	biological_process	rRNA processing
Cd	0019843	molecular_function	rRNA binding
Cd	0030687	cellular_component	preribosome, large subunit precursor
Cd	0042134	molecular_function	rRNA primary transcript binding
Cd	0042254	biological_process	ribosome biogenesis
Ce	0000460	biological_process	maturation of 5.8S rRNA
Ce	0000470	biological_process	maturation of LSU-rRNA
Ce	0005634	cellular_component	nucleus
Ce	0005730	cellular_component	nucleolus
Ce	0030687	cellular_component	preribosome, large subunit precursor
Cf	0003677	molecular_function	DNA binding
Cf	0003723	molecular_function	RNA binding
Cf	0005634	cellular_component	nucleus
Cf	0005730	cellular_component	nucleolus
Cf	0042273	biological_process	ribosomal large subunit biogenesis
Cf	0042274	biological_process	ribosomal small subunit biogenesis
Cg	0000027	biological_process	ribosomal large subunit assembly
Cg	0006364	biological_process	rRNA processing
Cg	0019843	molecular_function	rRNA binding
Cg	0030687	cellular_component	preribosome, large subunit precursor
Cg	0042254	biological_process	ribosome biogenesis
Ch	0000460	biological_process	maturation of 5.8S rRNA
Ch	0000470	biological_process	maturation of LSU-rRNA
Ch	0006364	biological_process	rRNA processing
Ch	0030687	cellular_component	preribosome, large subunit precursor
Cx	0005634	cellular_component	nucleus
Cx	0042254	biological_process	ribosome biogenesis
Cy	0000027	biological_process	ribosomal large subunit assembly
Cy	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cy	0000470	biological_process	maturation of LSU-rRNA
Cy	0005634	cellular_component	nucleus
Cy	0005730	cellular_component	nucleolus
Cy	0006364	biological_process	rRNA processing
Cy	0019843	molecular_function	rRNA binding
Cy	0042254	biological_process	ribosome biogenesis
LB	0003723	molecular_function	RNA binding
LB	0003735	molecular_function	structural constituent of ribosome
LB	0005840	cellular_component	ribosome
LB	0006412	biological_process	translation
LB	0022625	cellular_component	cytosolic large ribosomal subunit
LB	1990904	cellular_component	ribonucleoprotein complex
LC	0003735	molecular_function	structural constituent of ribosome
LC	0005840	cellular_component	ribosome
LC	0006412	biological_process	translation
LC	1990904	cellular_component	ribonucleoprotein complex
LD	0000027	biological_process	ribosomal large subunit assembly
LD	0003735	molecular_function	structural constituent of ribosome
LD	0005737	cellular_component	cytoplasm
LD	0005840	cellular_component	ribosome
LD	0006412	biological_process	translation
LD	0008097	molecular_function	5S rRNA binding
LD	0022625	cellular_component	cytosolic large ribosomal subunit
LD	1990904	cellular_component	ribonucleoprotein complex
LE	0000027	biological_process	ribosomal large subunit assembly
LE	0002181	biological_process	cytoplasmic translation
LE	0003723	molecular_function	RNA binding
LE	0003735	molecular_function	structural constituent of ribosome
LE	0005840	cellular_component	ribosome
LE	0006412	biological_process	translation
LE	0022625	cellular_component	cytosolic large ribosomal subunit
LE	1990904	cellular_component	ribonucleoprotein complex
LF	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LF	0003723	molecular_function	RNA binding
LF	0003735	molecular_function	structural constituent of ribosome
LF	0005840	cellular_component	ribosome
LF	0022625	cellular_component	cytosolic large ribosomal subunit
LF	1990904	cellular_component	ribonucleoprotein complex
LG	0003723	molecular_function	RNA binding
LG	0005840	cellular_component	ribosome
LG	0022625	cellular_component	cytosolic large ribosomal subunit
LG	0042254	biological_process	ribosome biogenesis
LG	1990904	cellular_component	ribonucleoprotein complex
LJ	0003735	molecular_function	structural constituent of ribosome
LJ	0005840	cellular_component	ribosome
LJ	0006412	biological_process	translation
LJ	1990904	cellular_component	ribonucleoprotein complex
LL	0003723	molecular_function	RNA binding
LL	0003735	molecular_function	structural constituent of ribosome
LL	0005840	cellular_component	ribosome
LL	0006412	biological_process	translation
LL	0022625	cellular_component	cytosolic large ribosomal subunit
LL	1990904	cellular_component	ribonucleoprotein complex
LM	0003723	molecular_function	RNA binding
LM	0003735	molecular_function	structural constituent of ribosome
LM	0005840	cellular_component	ribosome
LM	0006412	biological_process	translation
LM	0022625	cellular_component	cytosolic large ribosomal subunit
LM	0042273	biological_process	ribosomal large subunit biogenesis
LM	1990904	cellular_component	ribonucleoprotein complex
LN	0002181	biological_process	cytoplasmic translation
LN	0003723	molecular_function	RNA binding
LN	0003735	molecular_function	structural constituent of ribosome
LN	0005840	cellular_component	ribosome
LN	0006412	biological_process	translation
LN	0022625	cellular_component	cytosolic large ribosomal subunit
LN	1990904	cellular_component	ribonucleoprotein complex
LO	0003729	molecular_function	mRNA binding
LO	0003735	molecular_function	structural constituent of ribosome
LO	0005840	cellular_component	ribosome
LO	0006412	biological_process	translation
LO	0015934	cellular_component	large ribosomal subunit
LO	0017148	biological_process	negative regulation of translation
LO	0022625	cellular_component	cytosolic large ribosomal subunit
LO	1990904	cellular_component	ribonucleoprotein complex
LP	0002181	biological_process	cytoplasmic translation
LP	0003735	molecular_function	structural constituent of ribosome
LP	0005840	cellular_component	ribosome
LP	0006412	biological_process	translation
LP	0015934	cellular_component	large ribosomal subunit
LP	0022625	cellular_component	cytosolic large ribosomal subunit
LP	1990904	cellular_component	ribonucleoprotein complex
LQ	0003723	molecular_function	RNA binding
LQ	0003735	molecular_function	structural constituent of ribosome
LQ	0005840	cellular_component	ribosome
LQ	0006412	biological_process	translation
LQ	0022625	cellular_component	cytosolic large ribosomal subunit
LQ	1990904	cellular_component	ribonucleoprotein complex
LS	0003735	molecular_function	structural constituent of ribosome
LS	0005840	cellular_component	ribosome
LS	0006412	biological_process	translation
LS	1990904	cellular_component	ribonucleoprotein complex
LT	0003735	molecular_function	structural constituent of ribosome
LT	0005840	cellular_component	ribosome
LT	0006412	biological_process	translation
LT	1990904	cellular_component	ribonucleoprotein complex
LV	0003735	molecular_function	structural constituent of ribosome
LV	0005840	cellular_component	ribosome
LV	0006412	biological_process	translation
LV	0022625	cellular_component	cytosolic large ribosomal subunit
LV	0070180	molecular_function	large ribosomal subunit rRNA binding
LV	1990904	cellular_component	ribonucleoprotein complex
LY	0003723	molecular_function	RNA binding
LY	0003735	molecular_function	structural constituent of ribosome
LY	0005840	cellular_component	ribosome
LY	0006412	biological_process	translation
LY	0015934	cellular_component	large ribosomal subunit
LY	1990904	cellular_component	ribonucleoprotein complex
Le	0003735	molecular_function	structural constituent of ribosome
Le	0005840	cellular_component	ribosome
Le	0006412	biological_process	translation
Le	0022625	cellular_component	cytosolic large ribosomal subunit
Le	1990904	cellular_component	ribonucleoprotein complex
Lf	0003735	molecular_function	structural constituent of ribosome
Lf	0005840	cellular_component	ribosome
Lf	0006412	biological_process	translation
Lf	1990904	cellular_component	ribonucleoprotein complex
Lh	0003735	molecular_function	structural constituent of ribosome
Lh	0004576	molecular_function	oligosaccharyl transferase activity
Lh	0004579	molecular_function	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Lh	0005840	cellular_component	ribosome
Lh	0006412	biological_process	translation
Lh	0006486	biological_process	protein glycosylation
Lh	0012505	cellular_component	endomembrane system
Lh	0016020	cellular_component	membrane
Lh	0016757	molecular_function	glycosyltransferase activity
Lh	0018279	biological_process	protein N-linked glycosylation via asparagine
Lh	0043687	biological_process	post-translational protein modification
Lh	0046872	molecular_function	metal ion binding
Lh	1990904	cellular_component	ribonucleoprotein complex
Li	0003735	molecular_function	structural constituent of ribosome
Li	0005840	cellular_component	ribosome
Li	0006412	biological_process	translation
Li	1990904	cellular_component	ribonucleoprotein complex
Lj	0003723	molecular_function	RNA binding
Lj	0003735	molecular_function	structural constituent of ribosome
Lj	0005840	cellular_component	ribosome
Lj	0006412	biological_process	translation
Lj	0019843	molecular_function	rRNA binding
Lj	0022625	cellular_component	cytosolic large ribosomal subunit
Lj	0046872	molecular_function	metal ion binding
Lj	1990904	cellular_component	ribonucleoprotein complex
Lq	0003723	molecular_function	RNA binding
Lq	0003735	molecular_function	structural constituent of ribosome
Lq	0005840	cellular_component	ribosome
Lq	0006412	biological_process	translation
Lq	0015934	cellular_component	large ribosomal subunit
Lq	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. IIDEADRiL

Chain	Residue	Details
CE	ILE262-LEU270

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVIVrqakpwkrf.DGvflyFedNagVI

Chain	Residue	Details
LV	ALA78-ILE104

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLSGQtpVySkARyT

Chain	Residue	Details
LJ	LEU38-THR54

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsnpCHIELiL

Chain	Residue	Details
LP	ARG126-LEU150

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FekdemiDviAvTkGHGfvGvtaR

Chain	Residue	Details
LB	PHE210-ARG233

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGgdDgTVRVWEL

Chain	Residue	Details
CC	LEU468-LEU482

site_id	PS00783
Number of Residues	24
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. VRGMIPhktarGAaalerLkVFeG

Chain	Residue	Details
LO	VAL86-GLY109

site_id	PS00939
Number of Residues	27
Details	RIBOSOMAL_L1E Ribosomal protein L1e signature. NqgqKrfATaSALaASAvapllmaRGH

Chain	Residue	Details
LC	ASN115-HIS141

site_id	PS01077
Number of Residues	20
Details	RIBOSOMAL_L37E Ribosomal protein L37e signature. GTsSfGkRhnkt.HglCrRCG

Chain	Residue	Details
Lj	GLY4-GLY23

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CrkmgIPYaiIkGKarLG

Chain	Residue	Details
LG	CYS173-GLY190

site_id	PS01104
Number of Residues	15
Details	RIBOSOMAL_L13E Ribosomal protein L13e signature. RlGRGFTLeELkaaG

Chain	Residue	Details
LL	ARG70-GLY84

site_id	PS01105
Number of Residues	22
Details	RIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKItRpHGnsGvVrAkFthpLP

Chain	Residue	Details
Lf	GLY71-PRO92

site_id	PS01106
Number of Residues	18
Details	RIBOSOMAL_L18E Ribosomal protein L18e signature. RrLfmSRinRPpVSLsRI

Chain	Residue	Details
LQ	ARG78-ILE95

site_id	PS01153
Number of Residues	12
Details	NOL1_NOP2_SUN NOL1/NOP2/sun family signature. FDRVLlDAPCSG

Chain	Residue	Details
CP	PHE450-GLY461

site_id	PS01170
Number of Residues	19
Details	RIBOSOMAL_L6E Ribosomal protein L6e signature. NgvPLRRvnarYVIATSv.K

Chain	Residue	Details
LE	ASN90-LYS108

site_id	PS01171
Number of Residues	26
Details	RIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikvngavqk.GmpHkfYhGkTG

Chain	Residue	Details
LT	GLY37-GLY62

site_id	PS01190
Number of Residues	11
Details	RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRvIELLR

Chain	Residue	Details
Li	PRO61-ARG71

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGYVIYRvRVrRG

Chain	Residue	Details
LN	ASP46-GLY69

site_id	PS01199
Number of Residues	20
Details	RIBOSOMAL_L1 Ribosomal protein L1 signature. IkqIprlLGpgLSKAGkFPT

Chain	Residue	Details
Lq	ILE117-THR136

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01047

Chain	Residue	Details
CH	GLY173
CH	SER180
CH	PHE198
CH	THR200
CH	ASP219
CH	ASN287
CH	SER320

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)