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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8I6V

Cryo-EM structure of the polyphosphate polymerase VTC complex(Vtc4/Vtc3/Vtc1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000329cellular_componentfungal-type vacuole membrane
A0000421cellular_componentautophagosome membrane
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005774cellular_componentvacuolar membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005938cellular_componentcell cortex
A0006797biological_processpolyphosphate metabolic process
A0006799biological_processpolyphosphate biosynthetic process
A0007034biological_processvacuolar transport
A0016237biological_processmicroautophagy
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0033254cellular_componentvacuolar transporter chaperone complex
A0042144biological_processvacuole fusion, non-autophagic
A0061736biological_processengulfment of target by autophagosome
B0000329cellular_componentfungal-type vacuole membrane
B0000421cellular_componentautophagosome membrane
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005774cellular_componentvacuolar membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005938cellular_componentcell cortex
B0006797biological_processpolyphosphate metabolic process
B0006799biological_processpolyphosphate biosynthetic process
B0007034biological_processvacuolar transport
B0016237biological_processmicroautophagy
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0033254cellular_componentvacuolar transporter chaperone complex
B0042144biological_processvacuole fusion, non-autophagic
B0061736biological_processengulfment of target by autophagosome
C0000329cellular_componentfungal-type vacuole membrane
C0000421cellular_componentautophagosome membrane
C0003729molecular_functionmRNA binding
C0005515molecular_functionprotein binding
C0005774cellular_componentvacuolar membrane
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005938cellular_componentcell cortex
C0006797biological_processpolyphosphate metabolic process
C0006799biological_processpolyphosphate biosynthetic process
C0007034biological_processvacuolar transport
C0016237biological_processmicroautophagy
C0031410cellular_componentcytoplasmic vesicle
C0031965cellular_componentnuclear membrane
C0033254cellular_componentvacuolar transporter chaperone complex
C0042144biological_processvacuole fusion, non-autophagic
C0061736biological_processengulfment of target by autophagosome
D0000329cellular_componentfungal-type vacuole membrane
D0000421cellular_componentautophagosome membrane
D0000822molecular_functioninositol hexakisphosphate binding
D0005516molecular_functioncalmodulin binding
D0005774cellular_componentvacuolar membrane
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005938cellular_componentcell cortex
D0006797biological_processpolyphosphate metabolic process
D0006799biological_processpolyphosphate biosynthetic process
D0007034biological_processvacuolar transport
D0016237biological_processmicroautophagy
D0030643biological_processintracellular phosphate ion homeostasis
D0031410cellular_componentcytoplasmic vesicle
D0033254cellular_componentvacuolar transporter chaperone complex
D0042144biological_processvacuole fusion, non-autophagic
D0061736biological_processengulfment of target by autophagosome
E0000329cellular_componentfungal-type vacuole membrane
E0000421cellular_componentautophagosome membrane
E0000822molecular_functioninositol hexakisphosphate binding
E0005515molecular_functionprotein binding
E0005516molecular_functioncalmodulin binding
E0005774cellular_componentvacuolar membrane
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005938cellular_componentcell cortex
E0006797biological_processpolyphosphate metabolic process
E0006799biological_processpolyphosphate biosynthetic process
E0007034biological_processvacuolar transport
E0008976molecular_functionpolyphosphate kinase activity
E0016237biological_processmicroautophagy
E0016740molecular_functiontransferase activity
E0031410cellular_componentcytoplasmic vesicle
E0033254cellular_componentvacuolar transporter chaperone complex
E0061736biological_processengulfment of target by autophagosome
E0071944cellular_componentcell periphery
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues297
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues22
DetailsTopological domain: {"description":"Vacuolar","evidences":[{"source":"PubMed","id":"12584253","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues98
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"12584253","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues291
DetailsDomain: {"description":"SPX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00714","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues14
DetailsRegion: {"description":"Important for inositol polyphosphate binding","evidences":[{"source":"PubMed","id":"27080106","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues28
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues22
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsSite: {"description":"Important for inositol polyphosphate binding","evidences":[{"source":"UniProtKB","id":"P43585","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PubMed","id":"19390046","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19390046","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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