8I3P
crystal structure of yeast cytosine deaminase mutant yCD-RQ-1/8SAH in complex with (R)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004131 | molecular_function | cytosine deaminase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008655 | biological_process | pyrimidine-containing compound salvage |
A | 0008835 | molecular_function | diaminohydroxyphosphoribosylaminopyrimidine deaminase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016814 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
A | 0019239 | molecular_function | deaminase activity |
A | 0019858 | biological_process | cytosine metabolic process |
A | 0044206 | biological_process | UMP salvage |
A | 0046087 | biological_process | cytidine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
B | 0004131 | molecular_function | cytosine deaminase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008655 | biological_process | pyrimidine-containing compound salvage |
B | 0008835 | molecular_function | diaminohydroxyphosphoribosylaminopyrimidine deaminase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016814 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
B | 0019239 | molecular_function | deaminase activity |
B | 0019858 | biological_process | cytosine metabolic process |
B | 0044206 | biological_process | UMP salvage |
B | 0046087 | biological_process | cytidine metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
Functional Information from PROSITE/UniProt
site_id | PS00903 |
Number of Residues | 37 |
Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HGEisTLencgrlegkvykdttlyttls............PCdm......CtgaI |
Chain | Residue | Details |
A | HIS62-ILE98 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:12637534, ECO:0007744|PDB:1UAQ |
Chain | Residue | Details |
A | GLU64 | |
B | GLU64 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1UAQ |
Chain | Residue | Details |
A | ASN51 | |
A | ASP155 | |
B | ASN51 | |
B | ASP155 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0000269|PubMed:15879217, ECO:0007744|PDB:1OX7, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1RB7, ECO:0007744|PDB:1UAQ, ECO:0007744|PDB:1YSB, ECO:0007744|PDB:1YSD |
Chain | Residue | Details |
A | HIS62 | |
A | CYS91 | |
A | CYS94 | |
B | HIS62 | |
B | CYS91 | |
B | CYS94 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 636 |
Chain | Residue | Details |
A | HIS62 | metal ligand |
A | GLU64 | proton acceptor, proton donor |
A | SER89 | electrostatic stabiliser |
A | CYS91 | metal ligand |
A | CYS94 | metal ligand |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 636 |
Chain | Residue | Details |
B | HIS62 | metal ligand |
B | GLU64 | proton acceptor, proton donor |
B | SER89 | electrostatic stabiliser |
B | CYS91 | metal ligand |
B | CYS94 | metal ligand |