8HQ1
Crystal Structure Of Human Lgi1-Adam22 Complex In Space Group C2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
D | 0005102 | molecular_function | signaling receptor binding |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005615 | cellular_component | extracellular space |
D | 0005737 | cellular_component | cytoplasm |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005794 | cellular_component | Golgi apparatus |
D | 0007399 | biological_process | nervous system development |
D | 0007411 | biological_process | axon guidance |
D | 0030307 | biological_process | positive regulation of cell growth |
D | 0030425 | cellular_component | dendrite |
D | 0031175 | biological_process | neuron projection development |
D | 0043083 | cellular_component | synaptic cleft |
D | 0043194 | cellular_component | axon initial segment |
D | 0045202 | cellular_component | synapse |
D | 0050806 | biological_process | positive regulation of synaptic transmission |
D | 0098978 | cellular_component | glutamatergic synapse |
D | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
E | 0005102 | molecular_function | signaling receptor binding |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0005615 | cellular_component | extracellular space |
E | 0005737 | cellular_component | cytoplasm |
E | 0005783 | cellular_component | endoplasmic reticulum |
E | 0005794 | cellular_component | Golgi apparatus |
E | 0007399 | biological_process | nervous system development |
E | 0007411 | biological_process | axon guidance |
E | 0030307 | biological_process | positive regulation of cell growth |
E | 0030425 | cellular_component | dendrite |
E | 0031175 | biological_process | neuron projection development |
E | 0043083 | cellular_component | synaptic cleft |
E | 0043194 | cellular_component | axon initial segment |
E | 0045202 | cellular_component | synapse |
E | 0050806 | biological_process | positive regulation of synaptic transmission |
E | 0098978 | cellular_component | glutamatergic synapse |
E | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
F | 0005102 | molecular_function | signaling receptor binding |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0005615 | cellular_component | extracellular space |
F | 0005737 | cellular_component | cytoplasm |
F | 0005783 | cellular_component | endoplasmic reticulum |
F | 0005794 | cellular_component | Golgi apparatus |
F | 0007399 | biological_process | nervous system development |
F | 0007411 | biological_process | axon guidance |
F | 0030307 | biological_process | positive regulation of cell growth |
F | 0030425 | cellular_component | dendrite |
F | 0031175 | biological_process | neuron projection development |
F | 0043083 | cellular_component | synaptic cleft |
F | 0043194 | cellular_component | axon initial segment |
F | 0045202 | cellular_component | synapse |
F | 0050806 | biological_process | positive regulation of synaptic transmission |
F | 0098978 | cellular_component | glutamatergic synapse |
F | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue CA A 804 |
Chain | Residue |
A | GLU242 |
A | ASP325 |
A | CYS433 |
A | ASN436 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CA A 805 |
Chain | Residue |
A | ASP459 |
A | GLU446 |
A | ASN449 |
A | PHE451 |
A | GLU453 |
A | GLU456 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CA A 806 |
Chain | Residue |
A | ASP511 |
A | ILE512 |
A | GLU514 |
A | ASN526 |
A | ILE527 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue CA B 804 |
Chain | Residue |
B | ASP511 |
B | ILE512 |
B | GLU514 |
B | ASN526 |
B | ILE527 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue CA B 805 |
Chain | Residue |
B | GLU242 |
B | ASP325 |
B | CYS433 |
B | ASN436 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue CA B 806 |
Chain | Residue |
B | GLU446 |
B | ASN449 |
B | PHE451 |
B | GLU453 |
B | GLU456 |
B | ASP459 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue CA C 804 |
Chain | Residue |
C | ASP511 |
C | ILE512 |
C | GLU514 |
C | ASN526 |
C | ILE527 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue CA C 805 |
Chain | Residue |
C | GLU242 |
C | ASP325 |
C | CYS433 |
C | ASN436 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue CA C 806 |
Chain | Residue |
C | GLU446 |
C | CYS447 |
C | ASN449 |
C | PHE451 |
C | GLU453 |
C | GLU456 |
C | ASP459 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue CA D 604 |
Chain | Residue |
D | ASP334 |
D | ASP381 |
D | VAL382 |
D | GLU383 |
D | LYS436 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue CA E 604 |
Chain | Residue |
E | ASP334 |
E | GLU336 |
E | ASP381 |
E | VAL382 |
E | GLU383 |
E | LYS436 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue CA F 604 |
Chain | Residue |
F | ASP334 |
F | GLU336 |
F | ASP381 |
F | VAL382 |
F | GLU383 |
F | LYS436 |
site_id | AD4 |
Number of Residues | 2 |
Details | binding site for Mono-Saccharide NAG A 801 bound to ASN A 519 |
Chain | Residue |
A | SER517 |
A | ASN519 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for Mono-Saccharide NAG A 803 bound to ASN A 634 |
Chain | Residue |
A | SER623 |
A | LEU625 |
A | ASN634 |
A | SER636 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for Mono-Saccharide NAG A 802 bound to ASN A 675 |
Chain | Residue |
A | ASN675 |
C | LEU352 |
C | LYS353 |
C | ASP653 |
C | LEU664 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for Mono-Saccharide NAG B 801 bound to ASN B 519 |
Chain | Residue |
B | ASN519 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for Mono-Saccharide NAG B 803 bound to ASN B 634 |
Chain | Residue |
B | ASN607 |
B | SER623 |
B | LEU625 |
B | ASN634 |
site_id | AD9 |
Number of Residues | 1 |
Details | binding site for Mono-Saccharide NAG B 802 bound to ASN B 675 |
Chain | Residue |
B | ASN675 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for Mono-Saccharide NAG C 801 bound to ASN C 519 |
Chain | Residue |
C | SER517 |
C | ASN519 |
site_id | AE2 |
Number of Residues | 1 |
Details | binding site for Mono-Saccharide NAG C 803 bound to ASN C 634 |
Chain | Residue |
C | ASN634 |
site_id | AE3 |
Number of Residues | 1 |
Details | binding site for Mono-Saccharide NAG C 802 bound to ASN C 675 |
Chain | Residue |
C | ASN675 |
site_id | AE4 |
Number of Residues | 1 |
Details | binding site for Mono-Saccharide NAG D 602 bound to ASN D 192 |
Chain | Residue |
D | ASN192 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for Mono-Saccharide NAG D 603 bound to ASN D 277 |
Chain | Residue |
D | LYS259 |
D | ASN274 |
D | TYR275 |
D | ASP276 |
D | ASN277 |
site_id | AE6 |
Number of Residues | 1 |
Details | binding site for Mono-Saccharide NAG D 601 bound to ASN D 422 |
Chain | Residue |
D | ASN422 |
site_id | AE7 |
Number of Residues | 2 |
Details | binding site for Mono-Saccharide NAG E 602 bound to ASN E 192 |
Chain | Residue |
E | HIS190 |
E | ASN192 |
site_id | AE8 |
Number of Residues | 3 |
Details | binding site for Mono-Saccharide NAG E 603 bound to ASN E 277 |
Chain | Residue |
E | LYS259 |
E | ILE261 |
E | ASN277 |
site_id | AE9 |
Number of Residues | 2 |
Details | binding site for Mono-Saccharide NAG E 601 bound to ASN E 422 |
Chain | Residue |
E | ASN422 |
E | GLN423 |
site_id | AF1 |
Number of Residues | 3 |
Details | binding site for Mono-Saccharide NAG F 602 bound to ASN F 192 |
Chain | Residue |
F | ASP163 |
F | ASN192 |
F | LEU162 |
site_id | AF2 |
Number of Residues | 3 |
Details | binding site for Mono-Saccharide NAG F 603 bound to ASN F 277 |
Chain | Residue |
F | LYS259 |
F | ASN274 |
F | ASN277 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for Mono-Saccharide NAG F 601 bound to ASN F 422 |
Chain | Residue |
F | ARG389 |
F | GLN412 |
F | ASN422 |
F | GLN423 |
F | THR424 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 9 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
D | ASN192 | |
D | ASN277 | |
D | ASN422 | |
E | ASN192 | |
E | ASN277 | |
E | ASN422 | |
F | ASN192 | |
F | ASN277 | |
F | ASN422 |