8HPC
Crystal structure of C171A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-Hydroxyphenylglycine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| A | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| B | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| C | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| D | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| E | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| F | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| G | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| H | 0047417 | molecular_function | N-carbamoyl-D-amino acid hydrolase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU67 | |
| D | GLU67 | |
| D | LYS147 | |
| D | ALA192 | |
| E | GLU67 | |
| E | LYS147 | |
| E | ALA192 | |
| F | GLU67 | |
| F | LYS147 | |
| F | ALA192 | |
| G | GLU67 | |
| A | LYS147 | |
| G | LYS147 | |
| G | ALA192 | |
| H | GLU67 | |
| H | LYS147 | |
| H | ALA192 | |
| A | ALA192 | |
| B | GLU67 | |
| B | LYS147 | |
| B | ALA192 | |
| C | GLU67 | |
| C | LYS147 | |
| C | ALA192 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| A | GLU67 | proton shuttle (general acid/base) |
| A | LYS147 | electrostatic stabiliser |
| A | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| B | GLU67 | proton shuttle (general acid/base) |
| B | LYS147 | electrostatic stabiliser |
| B | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| C | GLU67 | proton shuttle (general acid/base) |
| C | LYS147 | electrostatic stabiliser |
| C | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| D | GLU67 | proton shuttle (general acid/base) |
| D | LYS147 | electrostatic stabiliser |
| D | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA5 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| E | GLU67 | proton shuttle (general acid/base) |
| E | LYS147 | electrostatic stabiliser |
| E | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA6 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| F | GLU67 | proton shuttle (general acid/base) |
| F | LYS147 | electrostatic stabiliser |
| F | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA7 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| G | GLU67 | proton shuttle (general acid/base) |
| G | LYS147 | electrostatic stabiliser |
| G | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA8 |
| Number of Residues | 3 |
| Details | M-CSA 674 |
| Chain | Residue | Details |
| H | GLU67 | proton shuttle (general acid/base) |
| H | LYS147 | electrostatic stabiliser |
| H | ALA192 | covalent catalysis, proton shuttle (general acid/base) |
