8HMZ

Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000213	molecular_function	tRNA-intron lyase activity
A	0000214	cellular_component	tRNA-intron endonuclease complex
A	0000379	biological_process	tRNA-type intron splice site recognition and cleavage
A	0003676	molecular_function	nucleic acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
A	0006397	biological_process	mRNA processing
A	0008033	biological_process	tRNA processing
A	0016829	molecular_function	lyase activity
B	0000213	molecular_function	tRNA-intron lyase activity
B	0000214	cellular_component	tRNA-intron endonuclease complex
B	0000379	biological_process	tRNA-type intron splice site recognition and cleavage
B	0003676	molecular_function	nucleic acid binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
B	0006397	biological_process	mRNA processing
B	0008033	biological_process	tRNA processing
B	0016829	molecular_function	lyase activity
C	0000214	cellular_component	tRNA-intron endonuclease complex
C	0000379	biological_process	tRNA-type intron splice site recognition and cleavage
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
C	0006397	biological_process	mRNA processing
C	0008033	biological_process	tRNA processing
D	0003676	molecular_function	nucleic acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
D	0006397	biological_process	mRNA processing
D	0008033	biological_process	tRNA processing
E	0000166	molecular_function	nucleotide binding
E	0000214	cellular_component	tRNA-intron endonuclease complex
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0005849	cellular_component	mRNA cleavage factor complex
E	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
E	0006396	biological_process	RNA processing
E	0006397	biological_process	mRNA processing
E	0008033	biological_process	tRNA processing
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0021695	biological_process	cerebellar cortex development
E	0031124	biological_process	mRNA 3'-end processing
E	0046404	molecular_function	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
E	0051731	molecular_function	polynucleotide 5'-hydroxyl-kinase activity
E	0051734	molecular_function	ATP-dependent polynucleotide 5'-hydroxyl-kinase activity
E	0051736	molecular_function	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
E	0070922	biological_process	RISC complex assembly
E	0098795	biological_process	global gene silencing by mRNA cleavage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6P7W5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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