Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8HMZ

Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000213molecular_functiontRNA-intron endonuclease activity
A0000214cellular_componenttRNA-intron endonuclease complex
A0000379biological_processtRNA-type intron splice site recognition and cleavage
A0003676molecular_functionnucleic acid binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0006388biological_processtRNA splicing, via endonucleolytic cleavage and ligation
A0006397biological_processmRNA processing
A0008033biological_processtRNA processing
A0016829molecular_functionlyase activity
B0000213molecular_functiontRNA-intron endonuclease activity
B0000214cellular_componenttRNA-intron endonuclease complex
B0000379biological_processtRNA-type intron splice site recognition and cleavage
B0003676molecular_functionnucleic acid binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0006388biological_processtRNA splicing, via endonucleolytic cleavage and ligation
B0006397biological_processmRNA processing
B0008033biological_processtRNA processing
B0016829molecular_functionlyase activity
C0000214cellular_componenttRNA-intron endonuclease complex
C0000379biological_processtRNA-type intron splice site recognition and cleavage
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0006388biological_processtRNA splicing, via endonucleolytic cleavage and ligation
C0006397biological_processmRNA processing
C0008033biological_processtRNA processing
D0003676molecular_functionnucleic acid binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0006388biological_processtRNA splicing, via endonucleolytic cleavage and ligation
D0006397biological_processmRNA processing
D0008033biological_processtRNA processing
E0000214cellular_componenttRNA-intron endonuclease complex
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005829cellular_componentcytosol
E0005849cellular_componentmRNA cleavage factor complex
E0006388biological_processtRNA splicing, via endonucleolytic cleavage and ligation
E0006396biological_processRNA processing
E0006397biological_processmRNA processing
E0008033biological_processtRNA processing
E0016301molecular_functionkinase activity
E0021695biological_processcerebellar cortex development
E0031124biological_processmRNA 3'-end processing
E0046404molecular_functionATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
E0051731molecular_functionpolynucleotide 5'-hydroxyl-kinase activity
E0051734molecular_functionATP-dependent polynucleotide 5'-hydroxyl-kinase activity
E0051736molecular_functionATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
E0070922biological_processRISC complex assembly
E0098795biological_processglobal gene silencing by mRNA cleavage
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER7
DSER172
EASP124

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
CSER178
ASER411
ASER415

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CTYR180

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER267

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
CARG316

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon