8HIO
Cryo-EM structure of the Cas12m2-crRNA binary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051607 | biological_process | defense response to virus |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051607 | biological_process | defense response to virus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Region: {"description":"Recognition domain (REC1-N)","evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | Region: {"description":"Recognition domain (REC1-C)","evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 111 |
| Details | Region: {"description":"Wedge domain (WED)","evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Region: {"description":"Linker","evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Region: {"description":"Target nucleic-acid binding (TNB)","evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 54 |
| Details | Coiled coil: {"evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HHL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37460897","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
