8HIN
Structure of human SGLT2-MAP17 complex with Phlorizin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000017 | biological_process | alpha-glucoside transport |
| A | 0005362 | molecular_function | low-affinity glucose:sodium symporter activity |
| A | 0005412 | molecular_function | glucose:sodium symporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0008645 | biological_process | hexose transmembrane transport |
| A | 0015151 | molecular_function | alpha-glucoside transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015370 | molecular_function | solute:sodium symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0035623 | biological_process | renal glucose absorption |
| A | 0055056 | molecular_function | D-glucose transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071702 | biological_process | organic substance transport |
| A | 0098708 | biological_process | glucose import across plasma membrane |
| A | 0098719 | biological_process | sodium ion import across plasma membrane |
| B | 0005515 | molecular_function | protein binding |
| B | 0016020 | cellular_component | membrane |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00456 |
| Number of Residues | 26 |
| Details | NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GwnIyasVIALLGItmiYTvtGGLaA |
| Chain | Residue | Details |
| A | GLY171-ALA196 |
| site_id | PS00457 |
| Number of Residues | 21 |
| Details | NA_SOLUT_SYMP_2 Sodium:solute symporter family signature 2. ALfvpRvneqGAfwGLIGGlL |
| Chain | Residue | Details |
| A | ALA474-LEU494 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | TRP30-VAL50 | |
| A | GLY83-ALA102 | |
| A | THR189-THR205 | |
| A | CYS292-CYS314 | |
| A | VAL444-TYR455 | |
| A | THR548-ALA650 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CQH0 |
| Chain | Residue | Details |
| B | SER85 | |
| A | LEU527-CYS547 | |
| A | ARG651-TYR671 | |
| A | MET62-VAL82 | |
| A | LEU103-ILE123 | |
| A | ALA169-TYR188 | |
| A | PHE206-TYR226 | |
| A | THR271-TRP291 | |
| A | ILE315-ILE334 | |
| A | LEU424-VAL443 | |
| A | ILE456-PHE476 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 240 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS45-SER61 | |
| A | THR124-GLN168 | |
| A | SER227-VAL270 | |
| A | SER335-LEU423 | |
| A | VAL477-TYR526 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Implicated in sodium coupling => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY40 | |
| A | ARG300 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN250 | |
| A | ASN399 |
