8HGG

Structure of 2:2 PAPP-A.ProMBP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006955	biological_process	immune response
B	0006955	biological_process	immune response
C	0008237	molecular_function	metallopeptidase activity
D	0008237	molecular_function	metallopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMIHEIGHSL

Chain	Residue	Details
C	THR479-LEU488

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site_id	PS00615
Number of Residues	24
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CValctrggh....WRRAHClrrlp.FIC

Chain	Residue	Details
A	CYS197-CYS220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
C	GLU483
D	GLU483
B	THR23
B	THR34

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
C	HIS482
C	HIS486
C	HIS492
D	HIS482
D	HIS486
D	HIS492

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site_id	SWS_FT_FI3
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN310
C	ASN745
C	ASN1142
C	ASN1385
D	ASN310
D	ASN745
D	ASN1142
D	ASN1385

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site_id	SWS_FT_FI4
Number of Residues	20
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12421832

Chain	Residue	Details
C	ASN322
C	ASN1439
D	ASN322
D	ASN349
D	ASN400
D	ASN521
D	ASN539
D	ASN645
D	ASN946
D	ASN1146
D	ASN1243
C	ASN349
D	ASN1439
C	ASN400
C	ASN521
C	ASN539
C	ASN645
C	ASN946
C	ASN1146
C	ASN1243

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:7524900, ECO:0000269|PubMed:8507662

Chain	Residue	Details
A	ASN86
B	ASN86

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