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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HF0

DmDcr-2/R2D2/LoqsPD with 50bp-dsRNA in Dimer state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002230biological_processpositive regulation of defense response to virus by host
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003730molecular_functionmRNA 3'-UTR binding
A0004386molecular_functionhelicase activity
A0004518molecular_functionnuclease activity
A0004525molecular_functionribonuclease III activity
A0004530molecular_functiondeoxyribonuclease I activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006309biological_processapoptotic DNA fragmentation
A0006396biological_processRNA processing
A0007626biological_processlocomotory behavior
A0008186molecular_functionATP-dependent activity, acting on RNA
A0009047biological_processdosage compensation by hyperactivation of X chromosome
A0009597biological_processdetection of virus
A0009616biological_processRNAi-mediated antiviral immune response
A0016442cellular_componentRISC complex
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0016891molecular_functionRNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
A0030422biological_processsiRNA processing
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031054biological_processpre-miRNA processing
A0031507biological_processheterochromatin formation
A0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
A0035197molecular_functionsiRNA binding
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0045089biological_processpositive regulation of innate immune response
A0045752biological_processpositive regulation of Toll signaling pathway
A0048471cellular_componentperinuclear region of cytoplasm
A0051607biological_processdefense response to virus
A0070578cellular_componentRISC-loading complex
A0070922biological_processRISC complex assembly
A0098586biological_processcellular response to virus
A0098795biological_processglobal gene silencing by mRNA cleavage
A0110064biological_processlncRNA catabolic process
C0003723molecular_functionRNA binding
C0003725molecular_functiondouble-stranded RNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0010468biological_processregulation of gene expression
C0016442cellular_componentRISC complex
C0030422biological_processsiRNA processing
C0030713biological_processfollicle cell of egg chamber stalk formation
C0035197molecular_functionsiRNA binding
C0051607biological_processdefense response to virus
C0070578cellular_componentRISC-loading complex
C0070920biological_processregulation of regulatory ncRNA processing
C0070922biological_processRISC complex assembly
D0000166molecular_functionnucleotide binding
D0002230biological_processpositive regulation of defense response to virus by host
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0003730molecular_functionmRNA 3'-UTR binding
D0004386molecular_functionhelicase activity
D0004518molecular_functionnuclease activity
D0004525molecular_functionribonuclease III activity
D0004530molecular_functiondeoxyribonuclease I activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0006309biological_processapoptotic DNA fragmentation
D0006396biological_processRNA processing
D0007626biological_processlocomotory behavior
D0008186molecular_functionATP-dependent activity, acting on RNA
D0009047biological_processdosage compensation by hyperactivation of X chromosome
D0009597biological_processdetection of virus
D0009616biological_processRNAi-mediated antiviral immune response
D0016442cellular_componentRISC complex
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0016891molecular_functionRNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
D0030422biological_processsiRNA processing
D0031047biological_processregulatory ncRNA-mediated gene silencing
D0031054biological_processpre-miRNA processing
D0031507biological_processheterochromatin formation
D0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
D0035197molecular_functionsiRNA binding
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0045089biological_processpositive regulation of innate immune response
D0045752biological_processpositive regulation of Toll signaling pathway
D0048471cellular_componentperinuclear region of cytoplasm
D0051607biological_processdefense response to virus
D0070578cellular_componentRISC-loading complex
D0070922biological_processRISC complex assembly
D0098586biological_processcellular response to virus
D0098795biological_processglobal gene silencing by mRNA cleavage
D0110064biological_processlncRNA catabolic process
E0003723molecular_functionRNA binding
E0003725molecular_functiondouble-stranded RNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0010468biological_processregulation of gene expression
E0016442cellular_componentRISC complex
E0030422biological_processsiRNA processing
E0030713biological_processfollicle cell of egg chamber stalk formation
E0035197molecular_functionsiRNA binding
E0051607biological_processdefense response to virus
E0070578cellular_componentRISC-loading complex
E0070920biological_processregulation of regulatory ncRNA processing
E0070922biological_processRISC complex assembly
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues356
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues340
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues204
DetailsDomain: {"description":"Dicer dsRNA-binding fold","evidences":[{"source":"PROSITE-ProRule","id":"PRU00657","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues108
DetailsDomain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues410
DetailsDomain: {"description":"RNase III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00177","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues44
DetailsDomain: {"description":"DRBM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00266","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues234
DetailsRegion: {"description":"Helicase insertion domain; involved in homodimerization","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues24
DetailsRegion: {"description":"Sufficient for interaction with loqs isoform PD (loqs-PD)","evidences":[{"source":"PubMed","id":"28874570","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues284
DetailsRegion: {"description":"Platform domain","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues188
DetailsRegion: {"description":"RNase III insertion domain a; involved in homodimerization","evidences":[{"source":"PubMed","id":"35768513","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues138
DetailsRegion: {"description":"Essential for efficient and high-fidelity siRNA production and siRNA loading","evidences":[{"source":"PubMed","id":"28416567","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsMotif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-07-30

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