8HC1

CryoEM structure of Helicobacter pylori UreFD/urease complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0009039	molecular_function	urease activity
A	0016151	molecular_function	nickel cation binding
A	0016787	molecular_function	hydrolase activity
A	0035550	cellular_component	urease complex
A	0043419	biological_process	urea catabolic process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0009039	molecular_function	urease activity
B	0016151	molecular_function	nickel cation binding
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0043419	biological_process	urea catabolic process
B	0046872	molecular_function	metal ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0016151	molecular_function	nickel cation binding
C	0018237	molecular_function	urease activator activity
C	0019627	biological_process	urea metabolic process
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0008152	biological_process	metabolic process
D	0016151	molecular_function	nickel cation binding
D	0018237	molecular_function	urease activator activity
D	0019627	biological_process	urea metabolic process
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0009039	molecular_function	urease activity
E	0016151	molecular_function	nickel cation binding
E	0016787	molecular_function	hydrolase activity
E	0035550	cellular_component	urease complex
E	0043419	biological_process	urea catabolic process
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0009039	molecular_function	urease activity
F	0016151	molecular_function	nickel cation binding
F	0016787	molecular_function	hydrolase activity
F	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
F	0043419	biological_process	urea catabolic process
F	0046872	molecular_function	metal ion binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0016151	molecular_function	nickel cation binding
G	0018237	molecular_function	urease activator activity
G	0019627	biological_process	urea metabolic process
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0008152	biological_process	metabolic process
H	0016151	molecular_function	nickel cation binding
H	0018237	molecular_function	urease activator activity
H	0019627	biological_process	urea metabolic process
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0009039	molecular_function	urease activity
I	0016151	molecular_function	nickel cation binding
I	0016787	molecular_function	hydrolase activity
I	0035550	cellular_component	urease complex
I	0043419	biological_process	urea catabolic process
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0009039	molecular_function	urease activity
J	0016151	molecular_function	nickel cation binding
J	0016787	molecular_function	hydrolase activity
J	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
J	0043419	biological_process	urea catabolic process
J	0046872	molecular_function	metal ion binding
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0016151	molecular_function	nickel cation binding
K	0018237	molecular_function	urease activator activity
K	0019627	biological_process	urea metabolic process
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0008152	biological_process	metabolic process
L	0016151	molecular_function	nickel cation binding
L	0018237	molecular_function	urease activator activity
L	0019627	biological_process	urea metabolic process
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0009039	molecular_function	urease activity
M	0016151	molecular_function	nickel cation binding
M	0016787	molecular_function	hydrolase activity
M	0035550	cellular_component	urease complex
M	0043419	biological_process	urea catabolic process
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0009039	molecular_function	urease activity
N	0016151	molecular_function	nickel cation binding
N	0016787	molecular_function	hydrolase activity
N	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
N	0043419	biological_process	urea catabolic process
N	0046872	molecular_function	metal ion binding
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0016151	molecular_function	nickel cation binding
O	0018237	molecular_function	urease activator activity
O	0019627	biological_process	urea metabolic process
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0008152	biological_process	metabolic process
P	0016151	molecular_function	nickel cation binding
P	0018237	molecular_function	urease activator activity
P	0019627	biological_process	urea metabolic process
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0009039	molecular_function	urease activity
Q	0016151	molecular_function	nickel cation binding
Q	0016787	molecular_function	hydrolase activity
Q	0035550	cellular_component	urease complex
Q	0043419	biological_process	urea catabolic process
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0009039	molecular_function	urease activity
R	0016151	molecular_function	nickel cation binding
R	0016787	molecular_function	hydrolase activity
R	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
R	0043419	biological_process	urea catabolic process
R	0046872	molecular_function	metal ion binding
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0016151	molecular_function	nickel cation binding
S	0018237	molecular_function	urease activator activity
S	0019627	biological_process	urea metabolic process
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0008152	biological_process	metabolic process
T	0016151	molecular_function	nickel cation binding
T	0018237	molecular_function	urease activator activity
T	0019627	biological_process	urea metabolic process
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0009039	molecular_function	urease activity
U	0016151	molecular_function	nickel cation binding
U	0016787	molecular_function	hydrolase activity
U	0035550	cellular_component	urease complex
U	0043419	biological_process	urea catabolic process
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0009039	molecular_function	urease activity
V	0016151	molecular_function	nickel cation binding
V	0016787	molecular_function	hydrolase activity
V	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
V	0043419	biological_process	urea catabolic process
V	0046872	molecular_function	metal ion binding
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0016151	molecular_function	nickel cation binding
W	0018237	molecular_function	urease activator activity
W	0019627	biological_process	urea metabolic process
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0008152	biological_process	metabolic process
X	0016151	molecular_function	nickel cation binding
X	0018237	molecular_function	urease activator activity
X	0019627	biological_process	urea metabolic process
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0009039	molecular_function	urease activity
Y	0016151	molecular_function	nickel cation binding
Y	0016787	molecular_function	hydrolase activity
Y	0035550	cellular_component	urease complex
Y	0043419	biological_process	urea catabolic process
Z	0005515	molecular_function	protein binding
Z	0005737	cellular_component	cytoplasm
Z	0009039	molecular_function	urease activity
Z	0016151	molecular_function	nickel cation binding
Z	0016787	molecular_function	hydrolase activity
Z	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Z	0043419	biological_process	urea catabolic process
Z	0046872	molecular_function	metal ion binding
a	0005515	molecular_function	protein binding
a	0005737	cellular_component	cytoplasm
a	0016151	molecular_function	nickel cation binding
a	0018237	molecular_function	urease activator activity
a	0019627	biological_process	urea metabolic process
b	0005515	molecular_function	protein binding
b	0005737	cellular_component	cytoplasm
b	0008152	biological_process	metabolic process
b	0016151	molecular_function	nickel cation binding
b	0018237	molecular_function	urease activator activity
b	0019627	biological_process	urea metabolic process
c	0005515	molecular_function	protein binding
c	0005737	cellular_component	cytoplasm
c	0009039	molecular_function	urease activity
c	0016151	molecular_function	nickel cation binding
c	0016787	molecular_function	hydrolase activity
c	0035550	cellular_component	urease complex
c	0043419	biological_process	urea catabolic process
d	0005515	molecular_function	protein binding
d	0005737	cellular_component	cytoplasm
d	0009039	molecular_function	urease activity
d	0016151	molecular_function	nickel cation binding
d	0016787	molecular_function	hydrolase activity
d	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
d	0043419	biological_process	urea catabolic process
d	0046872	molecular_function	metal ion binding
e	0005515	molecular_function	protein binding
e	0005737	cellular_component	cytoplasm
e	0016151	molecular_function	nickel cation binding
e	0018237	molecular_function	urease activator activity
e	0019627	biological_process	urea metabolic process
f	0005515	molecular_function	protein binding
f	0005737	cellular_component	cytoplasm
f	0008152	biological_process	metabolic process
f	0016151	molecular_function	nickel cation binding
f	0018237	molecular_function	urease activator activity
f	0019627	biological_process	urea metabolic process
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0009039	molecular_function	urease activity
g	0016151	molecular_function	nickel cation binding
g	0016787	molecular_function	hydrolase activity
g	0035550	cellular_component	urease complex
g	0043419	biological_process	urea catabolic process
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0009039	molecular_function	urease activity
h	0016151	molecular_function	nickel cation binding
h	0016787	molecular_function	hydrolase activity
h	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
h	0043419	biological_process	urea catabolic process
h	0046872	molecular_function	metal ion binding
i	0005515	molecular_function	protein binding
i	0005737	cellular_component	cytoplasm
i	0016151	molecular_function	nickel cation binding
i	0018237	molecular_function	urease activator activity
i	0019627	biological_process	urea metabolic process
j	0005515	molecular_function	protein binding
j	0005737	cellular_component	cytoplasm
j	0008152	biological_process	metabolic process
j	0016151	molecular_function	nickel cation binding
j	0018237	molecular_function	urease activator activity
j	0019627	biological_process	urea metabolic process
k	0005515	molecular_function	protein binding
k	0005737	cellular_component	cytoplasm
k	0009039	molecular_function	urease activity
k	0016151	molecular_function	nickel cation binding
k	0016787	molecular_function	hydrolase activity
k	0035550	cellular_component	urease complex
k	0043419	biological_process	urea catabolic process
l	0005515	molecular_function	protein binding
l	0005737	cellular_component	cytoplasm
l	0009039	molecular_function	urease activity
l	0016151	molecular_function	nickel cation binding
l	0016787	molecular_function	hydrolase activity
l	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
l	0043419	biological_process	urea catabolic process
l	0046872	molecular_function	metal ion binding
m	0005515	molecular_function	protein binding
m	0005737	cellular_component	cytoplasm
m	0016151	molecular_function	nickel cation binding
m	0018237	molecular_function	urease activator activity
m	0019627	biological_process	urea metabolic process
n	0005515	molecular_function	protein binding
n	0005737	cellular_component	cytoplasm
n	0008152	biological_process	metabolic process
n	0016151	molecular_function	nickel cation binding
n	0018237	molecular_function	urease activator activity
n	0019627	biological_process	urea metabolic process
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0009039	molecular_function	urease activity
o	0016151	molecular_function	nickel cation binding
o	0016787	molecular_function	hydrolase activity
o	0035550	cellular_component	urease complex
o	0043419	biological_process	urea catabolic process
p	0005515	molecular_function	protein binding
p	0005737	cellular_component	cytoplasm
p	0009039	molecular_function	urease activity
p	0016151	molecular_function	nickel cation binding
p	0016787	molecular_function	hydrolase activity
p	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
p	0043419	biological_process	urea catabolic process
p	0046872	molecular_function	metal ion binding
q	0005515	molecular_function	protein binding
q	0005737	cellular_component	cytoplasm
q	0016151	molecular_function	nickel cation binding
q	0018237	molecular_function	urease activator activity
q	0019627	biological_process	urea metabolic process
r	0005515	molecular_function	protein binding
r	0005737	cellular_component	cytoplasm
r	0008152	biological_process	metabolic process
r	0016151	molecular_function	nickel cation binding
r	0018237	molecular_function	urease activator activity
r	0019627	biological_process	urea metabolic process
s	0005515	molecular_function	protein binding
s	0005737	cellular_component	cytoplasm
s	0009039	molecular_function	urease activity
s	0016151	molecular_function	nickel cation binding
s	0016787	molecular_function	hydrolase activity
s	0035550	cellular_component	urease complex
s	0043419	biological_process	urea catabolic process
t	0005515	molecular_function	protein binding
t	0005737	cellular_component	cytoplasm
t	0009039	molecular_function	urease activity
t	0016151	molecular_function	nickel cation binding
t	0016787	molecular_function	hydrolase activity
t	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
t	0043419	biological_process	urea catabolic process
t	0046872	molecular_function	metal ion binding
u	0005515	molecular_function	protein binding
u	0005737	cellular_component	cytoplasm
u	0016151	molecular_function	nickel cation binding
u	0018237	molecular_function	urease activator activity
u	0019627	biological_process	urea metabolic process
v	0005515	molecular_function	protein binding
v	0005737	cellular_component	cytoplasm
v	0008152	biological_process	metabolic process
v	0016151	molecular_function	nickel cation binding
v	0018237	molecular_function	urease activator activity
v	0019627	biological_process	urea metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00145
Number of Residues	17
Details	UREASE_2 Urease active site. MVCHHLdksIkeDVqFA

Chain	Residue	Details
B	MET319-ALA335

---

site_id	PS01120
Number of Residues	14
Details	UREASE_1 Urease nickel ligands signature. TAGGIDtHIHfisP

Chain	Residue	Details
B	THR129-PRO142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1212
Details	Region: {"description":"Urease gamma"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1620
Details	Region: {"description":"Urease beta"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5256
Details	Domain: {"description":"Urease","evidences":[{"source":"HAMAP-Rule","id":"MF_01953","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"description":"via carbamate group"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01953","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11373617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---