Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HB0

Structure of human SGLT2-MAP17 complex with TA1887

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000017	biological_process	alpha-glucoside transport
A	0005362	molecular_function	low-affinity D-glucose:sodium symporter activity
A	0005412	molecular_function	D-glucose:sodium symporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0008645	biological_process	hexose transmembrane transport
A	0015151	molecular_function	alpha-glucoside transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015370	molecular_function	solute:sodium symporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035623	biological_process	renal D-glucose absorption
A	0046872	molecular_function	metal ion binding
A	0055056	molecular_function	D-glucose transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0098708	biological_process	D-glucose import across plasma membrane
A	0098719	biological_process	sodium ion import across plasma membrane
A	1904659	biological_process	D-glucose transmembrane transport
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00456
Number of Residues	26
Details	NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GwnIyasVIALLGItmiYTvtGGLaA

Chain	Residue	Details
A	GLY171-ALA196

site_id	PS00457
Number of Residues	21
Details	NA_SOLUT_SYMP_2 Sodium:solute symporter family signature 2. ALfvpRvneqGAfwGLIGGlL

Chain	Residue	Details
A	ALA474-LEU494

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	135
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	13
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=TM13","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	22
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"34880493","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37217492","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38057552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)