8H65
Crystal structure of human GCN5 histone acetyltransferase domain bound with butyryl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0004402 | molecular_function | histone acetyltransferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0004402 | molecular_function | histone acetyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| G | 0004402 | molecular_function | histone acetyltransferase activity |
| G | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| H | 0004402 | molecular_function | histone acetyltransferase activity |
| H | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:31527837 |
| Chain | Residue | Details |
| C | GLU575 | |
| D | GLU575 | |
| E | GLU575 | |
| F | GLU575 | |
| B | GLU575 | |
| A | GLU575 | |
| G | GLU575 | |
| H | GLU575 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29211711, ECO:0007744|PDB:5TRL |
| Chain | Residue | Details |
| C | CYS579 | |
| F | CYS579 | |
| F | GLN586 | |
| F | TYR617 | |
| B | CYS579 | |
| B | GLN586 | |
| B | TYR617 | |
| A | CYS579 | |
| A | GLN586 | |
| A | TYR617 | |
| G | CYS579 | |
| C | GLN586 | |
| G | GLN586 | |
| G | TYR617 | |
| H | CYS579 | |
| H | GLN586 | |
| H | TYR617 | |
| C | TYR617 | |
| D | CYS579 | |
| D | GLN586 | |
| D | TYR617 | |
| E | CYS579 | |
| E | GLN586 | |
| E | TYR617 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:23142079 |
| Chain | Residue | Details |
| C | LYS549 | |
| D | LYS549 | |
| E | LYS549 | |
| F | LYS549 | |
| B | LYS549 | |
| A | LYS549 | |
| G | LYS549 | |
| H | LYS549 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| C | PHE568 | electrostatic stabiliser |
| C | PHE573 | electrostatic stabiliser |
| C | GLU575 | proton acceptor |
| C | ILE576 | electrostatic stabiliser |
| C | VAL577 | electrostatic stabiliser |
| C | CYS579 | electrostatic stabiliser |
| C | LEU611 | electrostatic stabiliser |
| C | ILE642 | electrostatic stabiliser |
| C | TYR645 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| D | PHE568 | electrostatic stabiliser |
| D | PHE573 | electrostatic stabiliser |
| D | GLU575 | proton acceptor |
| D | ILE576 | electrostatic stabiliser |
| D | VAL577 | electrostatic stabiliser |
| D | CYS579 | electrostatic stabiliser |
| D | LEU611 | electrostatic stabiliser |
| D | ILE642 | electrostatic stabiliser |
| D | TYR645 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| E | PHE568 | electrostatic stabiliser |
| E | PHE573 | electrostatic stabiliser |
| E | GLU575 | proton acceptor |
| E | ILE576 | electrostatic stabiliser |
| E | VAL577 | electrostatic stabiliser |
| E | CYS579 | electrostatic stabiliser |
| E | LEU611 | electrostatic stabiliser |
| E | ILE642 | electrostatic stabiliser |
| E | TYR645 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| F | PHE568 | electrostatic stabiliser |
| F | PHE573 | electrostatic stabiliser |
| F | GLU575 | proton acceptor |
| F | ILE576 | electrostatic stabiliser |
| F | VAL577 | electrostatic stabiliser |
| F | CYS579 | electrostatic stabiliser |
| F | LEU611 | electrostatic stabiliser |
| F | ILE642 | electrostatic stabiliser |
| F | TYR645 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| B | PHE568 | electrostatic stabiliser |
| B | PHE573 | electrostatic stabiliser |
| B | GLU575 | proton acceptor |
| B | ILE576 | electrostatic stabiliser |
| B | VAL577 | electrostatic stabiliser |
| B | CYS579 | electrostatic stabiliser |
| B | LEU611 | electrostatic stabiliser |
| B | ILE642 | electrostatic stabiliser |
| B | TYR645 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| A | PHE568 | electrostatic stabiliser |
| A | PHE573 | electrostatic stabiliser |
| A | GLU575 | proton acceptor |
| A | ILE576 | electrostatic stabiliser |
| A | VAL577 | electrostatic stabiliser |
| A | CYS579 | electrostatic stabiliser |
| A | LEU611 | electrostatic stabiliser |
| A | ILE642 | electrostatic stabiliser |
| A | TYR645 | electrostatic stabiliser |
| site_id | MCSA7 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| G | PHE568 | electrostatic stabiliser |
| G | PHE573 | electrostatic stabiliser |
| G | GLU575 | proton acceptor |
| G | ILE576 | electrostatic stabiliser |
| G | VAL577 | electrostatic stabiliser |
| G | CYS579 | electrostatic stabiliser |
| G | LEU611 | electrostatic stabiliser |
| G | ILE642 | electrostatic stabiliser |
| G | TYR645 | electrostatic stabiliser |
| site_id | MCSA8 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| H | PHE568 | electrostatic stabiliser |
| H | PHE573 | electrostatic stabiliser |
| H | GLU575 | proton acceptor |
| H | ILE576 | electrostatic stabiliser |
| H | VAL577 | electrostatic stabiliser |
| H | CYS579 | electrostatic stabiliser |
| H | LEU611 | electrostatic stabiliser |
| H | ILE642 | electrostatic stabiliser |
| H | TYR645 | electrostatic stabiliser |
