8H40
Cryo-EM structure of the transcription activation complex NtcA-TAC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0032549 | molecular_function | ribonucleoside binding |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0046983 | molecular_function | protein dimerization activity |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0046983 | molecular_function | protein dimerization activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| E | 0006351 | biological_process | DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| F | 0006351 | biological_process | DNA-templated transcription |
| F | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006352 | biological_process | DNA-templated transcription initiation |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0010468 | biological_process | regulation of gene expression |
| G | 0016987 | molecular_function | sigma factor activity |
| G | 2000142 | biological_process | regulation of DNA-templated transcription initiation |
| X | 0003677 | molecular_function | DNA binding |
| X | 0003700 | molecular_function | DNA-binding transcription factor activity |
| X | 0005829 | cellular_component | cytosol |
| X | 0006355 | biological_process | regulation of DNA-templated transcription |
| Y | 0003677 | molecular_function | DNA binding |
| Y | 0003700 | molecular_function | DNA-binding transcription factor activity |
| Y | 0005829 | cellular_component | cytosol |
| Y | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS00042 |
| Number of Residues | 24 |
| Details | HTH_CRP_1 Crp-type HTH domain signature. LSHqaIAeAIGsTrvTv.TRlLgdL |
| Chain | Residue | Details |
| X | LEU174-LEU197 |
| site_id | PS00715 |
| Number of Residues | 14 |
| Details | SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGsLGLIrAA |
| Chain | Residue | Details |
| G | ASP182-ALA195 |
| site_id | PS00716 |
| Number of Residues | 27 |
| Details | SIGMA70_2 Sigma-70 factors family signature 2. TleEIGqifnVTrerIrQIEakaLrkL |
| Chain | Residue | Details |
| G | THR350-LEU376 |
| site_id | PS01166 |
| Number of Residues | 13 |
| Details | RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGI |
| Chain | Residue | Details |
| A | GLY849-ILE861 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01324","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01323","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 70 |
| Details | Region: {"description":"Sigma-70 factor domain-2","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 75 |
| Details | Region: {"description":"Sigma-70 factor domain-3","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 53 |
| Details | Region: {"description":"Sigma-70 factor domain-4","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Interaction with polymerase core subunit RpoC"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 146 |
| Details | Domain: {"description":"HTH crp-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00387","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00387","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
