8H37

Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006006	biological_process	glucose metabolic process
A	0006629	biological_process	lipid metabolic process
A	0010467	biological_process	gene expression
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0032868	biological_process	response to insulin
A	0032869	biological_process	cellular response to insulin stimulus
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0070936	biological_process	protein K48-linked ubiquitination
A	1900076	biological_process	regulation of cellular response to insulin stimulus
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0005737	cellular_component	cytoplasm
B	0006006	biological_process	glucose metabolic process
B	0006629	biological_process	lipid metabolic process
B	0010467	biological_process	gene expression
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0032868	biological_process	response to insulin
B	0032869	biological_process	cellular response to insulin stimulus
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0070936	biological_process	protein K48-linked ubiquitination
B	1900076	biological_process	regulation of cellular response to insulin stimulus
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000209	biological_process	protein polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0000902	biological_process	cell morphogenesis
C	0000922	cellular_component	spindle pole
C	0001701	biological_process	in utero embryonic development
C	0001822	biological_process	kidney development
C	0001831	biological_process	trophectodermal cellular morphogenesis
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005827	cellular_component	polar microtubule
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006366	biological_process	transcription by RNA polymerase II
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0006954	biological_process	inflammatory response
C	0006979	biological_process	response to oxidative stress
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007165	biological_process	signal transduction
C	0007229	biological_process	integrin-mediated signaling pathway
C	0007369	biological_process	gastrulation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010467	biological_process	gene expression
C	0010468	biological_process	regulation of gene expression
C	0010558	biological_process	negative regulation of macromolecule biosynthetic process
C	0016020	cellular_component	membrane
C	0016055	biological_process	Wnt signaling pathway
C	0016192	biological_process	vesicle-mediated transport
C	0016477	biological_process	cell migration
C	0016567	biological_process	protein ubiquitination
C	0017145	biological_process	stem cell division
C	0030030	biological_process	cell projection organization
C	0030163	biological_process	protein catabolic process
C	0030332	molecular_function	cyclin binding
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0031208	molecular_function	POZ domain binding
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031514	cellular_component	motile cilium
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031648	biological_process	protein destabilization
C	0031669	biological_process	cellular response to nutrient levels
C	0032467	biological_process	positive regulation of cytokinesis
C	0032480	biological_process	negative regulation of type I interferon production
C	0032481	biological_process	positive regulation of type I interferon production
C	0032869	biological_process	cellular response to insulin stimulus
C	0034198	biological_process	cellular response to amino acid starvation
C	0034599	biological_process	cellular response to oxidative stress
C	0035024	biological_process	negative regulation of Rho protein signal transduction
C	0036126	cellular_component	sperm flagellum
C	0040016	biological_process	embryonic cleavage
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044346	biological_process	fibroblast apoptotic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0048208	biological_process	COPII vesicle coating
C	0051301	biological_process	cell division
C	0051865	biological_process	protein autoubiquitination
C	0060337	biological_process	type I interferon-mediated signaling pathway
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070062	cellular_component	extracellular exosome
C	0070294	biological_process	renal sodium ion absorption
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
C	0072576	biological_process	liver morphogenesis
C	0072686	cellular_component	mitotic spindle
C	0080090	biological_process	regulation of primary metabolic process
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0140252	biological_process	regulation protein catabolic process at postsynapse
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0000045	biological_process	autophagosome assembly
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0000423	biological_process	mitophagy
D	0001837	biological_process	epithelial to mesenchymal transition
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0007040	biological_process	lysosome organization
D	0007283	biological_process	spermatogenesis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008270	molecular_function	zinc ion binding
D	0008286	biological_process	insulin receptor signaling pathway
D	0010507	biological_process	negative regulation of autophagy
D	0010508	biological_process	positive regulation of autophagy
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0032481	biological_process	positive regulation of type I interferon production
D	0032869	biological_process	cellular response to insulin stimulus
D	0034198	biological_process	cellular response to amino acid starvation
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
D	0038066	biological_process	p38MAPK cascade
D	0038202	biological_process	TORC1 signaling
D	0042110	biological_process	T cell activation
D	0042770	biological_process	signal transduction in response to DNA damage
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045727	biological_process	positive regulation of translation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070294	biological_process	renal sodium ion absorption
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901525	biological_process	negative regulation of mitophagy
D	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904037	biological_process	positive regulation of epithelial cell apoptotic process
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
D	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
E	0000045	biological_process	autophagosome assembly
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000165	biological_process	MAPK cascade
E	0000209	biological_process	protein polyubiquitination
E	0000423	biological_process	mitophagy
E	0001837	biological_process	epithelial to mesenchymal transition
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006283	biological_process	transcription-coupled nucleotide-excision repair
E	0006366	biological_process	transcription by RNA polymerase II
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006513	biological_process	protein monoubiquitination
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007040	biological_process	lysosome organization
E	0007283	biological_process	spermatogenesis
E	0007346	biological_process	regulation of mitotic cell cycle
E	0008270	molecular_function	zinc ion binding
E	0008286	biological_process	insulin receptor signaling pathway
E	0010507	biological_process	negative regulation of autophagy
E	0010508	biological_process	positive regulation of autophagy
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0019788	molecular_function	NEDD8 transferase activity
E	0030163	biological_process	protein catabolic process
E	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
E	0030891	cellular_component	VCB complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032480	biological_process	negative regulation of type I interferon production
E	0032481	biological_process	positive regulation of type I interferon production
E	0032869	biological_process	cellular response to insulin stimulus
E	0034198	biological_process	cellular response to amino acid starvation
E	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034644	biological_process	cellular response to UV
E	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
E	0038066	biological_process	p38MAPK cascade
E	0038202	biological_process	TORC1 signaling
E	0042110	biological_process	T cell activation
E	0042770	biological_process	signal transduction in response to DNA damage
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043687	biological_process	post-translational protein modification
E	0044877	molecular_function	protein-containing complex binding
E	0045116	biological_process	protein neddylation
E	0045727	biological_process	positive regulation of translation
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046627	biological_process	negative regulation of insulin receptor signaling pathway
E	0046872	molecular_function	metal ion binding
E	0060090	molecular_function	molecular adaptor activity
E	0060337	biological_process	type I interferon-mediated signaling pathway
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061663	molecular_function	NEDD8 ligase activity
E	0062197	biological_process	cellular response to chemical stress
E	0070294	biological_process	renal sodium ion absorption
E	0070936	biological_process	protein K48-linked ubiquitination
E	0071230	biological_process	cellular response to amino acid stimulus
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090734	cellular_component	site of DNA damage
E	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
E	0097602	molecular_function	cullin family protein binding
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	1900076	biological_process	regulation of cellular response to insulin stimulus
E	1901525	biological_process	negative regulation of mitophagy
E	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
E	1902499	biological_process	positive regulation of protein autoubiquitination
E	1902883	biological_process	negative regulation of response to oxidative stress
E	1904037	biological_process	positive regulation of epithelial cell apoptotic process
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
E	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000209	biological_process	protein polyubiquitination
F	0000278	biological_process	mitotic cell cycle
F	0000902	biological_process	cell morphogenesis
F	0000922	cellular_component	spindle pole
F	0001701	biological_process	in utero embryonic development
F	0001822	biological_process	kidney development
F	0001831	biological_process	trophectodermal cellular morphogenesis
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005112	molecular_function	Notch binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005827	cellular_component	polar microtubule
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006513	biological_process	protein monoubiquitination
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006915	biological_process	apoptotic process
F	0006950	biological_process	response to stress
F	0006954	biological_process	inflammatory response
F	0006979	biological_process	response to oxidative stress
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0007165	biological_process	signal transduction
F	0007229	biological_process	integrin-mediated signaling pathway
F	0007369	biological_process	gastrulation
F	0008284	biological_process	positive regulation of cell population proliferation
F	0010467	biological_process	gene expression
F	0010468	biological_process	regulation of gene expression
F	0010558	biological_process	negative regulation of macromolecule biosynthetic process
F	0016020	cellular_component	membrane
F	0016055	biological_process	Wnt signaling pathway
F	0016192	biological_process	vesicle-mediated transport
F	0016477	biological_process	cell migration
F	0016567	biological_process	protein ubiquitination
F	0017145	biological_process	stem cell division
F	0030030	biological_process	cell projection organization
F	0030163	biological_process	protein catabolic process
F	0030332	molecular_function	cyclin binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0031208	molecular_function	POZ domain binding
F	0031398	biological_process	positive regulation of protein ubiquitination
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
F	0031514	cellular_component	motile cilium
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031648	biological_process	protein destabilization
F	0031669	biological_process	cellular response to nutrient levels
F	0032467	biological_process	positive regulation of cytokinesis
F	0032480	biological_process	negative regulation of type I interferon production
F	0032481	biological_process	positive regulation of type I interferon production
F	0032869	biological_process	cellular response to insulin stimulus
F	0034198	biological_process	cellular response to amino acid starvation
F	0034599	biological_process	cellular response to oxidative stress
F	0035024	biological_process	negative regulation of Rho protein signal transduction
F	0036126	cellular_component	sperm flagellum
F	0040016	biological_process	embryonic cleavage
F	0042802	molecular_function	identical protein binding
F	0042995	cellular_component	cell projection
F	0043149	biological_process	stress fiber assembly
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0044346	biological_process	fibroblast apoptotic process
F	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
F	0048208	biological_process	COPII vesicle coating
F	0051301	biological_process	cell division
F	0051865	biological_process	protein autoubiquitination
F	0060337	biological_process	type I interferon-mediated signaling pathway
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0070062	cellular_component	extracellular exosome
F	0070294	biological_process	renal sodium ion absorption
F	0070936	biological_process	protein K48-linked ubiquitination
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
F	0072576	biological_process	liver morphogenesis
F	0072686	cellular_component	mitotic spindle
F	0080090	biological_process	regulation of primary metabolic process
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0140252	biological_process	regulation protein catabolic process at postsynapse
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	0160240	biological_process	RNA polymerase II transcription initiation surveillance
F	1900076	biological_process	regulation of cellular response to insulin stimulus
F	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0001678	biological_process	intracellular glucose homeostasis
G	0001784	molecular_function	phosphotyrosine residue binding
G	0001953	biological_process	negative regulation of cell-matrix adhesion
G	0002687	biological_process	positive regulation of leukocyte migration
G	0005068	molecular_function	transmembrane receptor protein tyrosine kinase adaptor activity
G	0005096	molecular_function	GTPase activator activity
G	0005158	molecular_function	insulin receptor binding
G	0005159	molecular_function	insulin-like growth factor receptor binding
G	0005168	molecular_function	neurotrophin TRKA receptor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005801	cellular_component	cis-Golgi network
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005911	cellular_component	cell-cell junction
G	0005942	cellular_component	phosphatidylinositol 3-kinase complex
G	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
G	0006366	biological_process	transcription by RNA polymerase II
G	0006606	biological_process	protein import into nucleus
G	0006955	biological_process	immune response
G	0007162	biological_process	negative regulation of cell adhesion
G	0007165	biological_process	signal transduction
G	0008286	biological_process	insulin receptor signaling pathway
G	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
G	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
G	0010592	biological_process	positive regulation of lamellipodium assembly
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0019207	molecular_function	kinase regulator activity
G	0019209	molecular_function	kinase activator activity
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0019903	molecular_function	protein phosphatase binding
G	0030183	biological_process	B cell differentiation
G	0030217	biological_process	T cell differentiation
G	0030316	biological_process	osteoclast differentiation
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0032869	biological_process	cellular response to insulin stimulus
G	0033120	biological_process	positive regulation of RNA splicing
G	0034143	biological_process	regulation of toll-like receptor 4 signaling pathway
G	0034446	biological_process	substrate adhesion-dependent cell spreading
G	0034644	biological_process	cellular response to UV
G	0034976	biological_process	response to endoplasmic reticulum stress
G	0035014	molecular_function	phosphatidylinositol 3-kinase regulator activity
G	0035655	biological_process	interleukin-18-mediated signaling pathway
G	0036312	molecular_function	phosphatidylinositol 3-kinase regulatory subunit binding
G	0042267	biological_process	natural killer cell mediated cytotoxicity
G	0042307	biological_process	positive regulation of protein import into nucleus
G	0043066	biological_process	negative regulation of apoptotic process
G	0043125	molecular_function	ErbB-3 class receptor binding
G	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0043548	molecular_function	phosphatidylinositol 3-kinase binding
G	0043559	molecular_function	insulin binding
G	0043560	molecular_function	insulin receptor substrate binding
G	0045671	biological_process	negative regulation of osteoclast differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046326	biological_process	positive regulation of D-glucose import
G	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
G	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
G	0046982	molecular_function	protein heterodimerization activity
G	0048009	biological_process	insulin-like growth factor receptor signaling pathway
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048661	biological_process	positive regulation of smooth muscle cell proliferation
G	0050821	biological_process	protein stabilization
G	0051491	biological_process	positive regulation of filopodium assembly
G	0051492	biological_process	regulation of stress fiber assembly
G	0051497	biological_process	negative regulation of stress fiber assembly
G	0052742	molecular_function	phosphatidylinositol kinase activity
G	0060396	biological_process	growth hormone receptor signaling pathway
G	0061470	biological_process	T follicular helper cell differentiation
G	0097529	biological_process	myeloid leukocyte migration
G	0120183	biological_process	positive regulation of focal adhesion disassembly
G	0140767	molecular_function	enzyme-substrate adaptor activity
G	0141038	molecular_function	phosphatidylinositol 3-kinase activator activity
G	1900103	biological_process	positive regulation of endoplasmic reticulum unfolded protein response
G	1903076	biological_process	regulation of protein localization to plasma membrane
G	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	1990578	cellular_component	perinuclear endoplasmic reticulum membrane
H	0001678	biological_process	intracellular glucose homeostasis
H	0001784	molecular_function	phosphotyrosine residue binding
H	0001953	biological_process	negative regulation of cell-matrix adhesion
H	0002687	biological_process	positive regulation of leukocyte migration
H	0005068	molecular_function	transmembrane receptor protein tyrosine kinase adaptor activity
H	0005096	molecular_function	GTPase activator activity
H	0005158	molecular_function	insulin receptor binding
H	0005159	molecular_function	insulin-like growth factor receptor binding
H	0005168	molecular_function	neurotrophin TRKA receptor binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005801	cellular_component	cis-Golgi network
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0005942	cellular_component	phosphatidylinositol 3-kinase complex
H	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
H	0006366	biological_process	transcription by RNA polymerase II
H	0006606	biological_process	protein import into nucleus
H	0006955	biological_process	immune response
H	0007162	biological_process	negative regulation of cell adhesion
H	0007165	biological_process	signal transduction
H	0008286	biological_process	insulin receptor signaling pathway
H	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
H	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
H	0010592	biological_process	positive regulation of lamellipodium assembly
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0019207	molecular_function	kinase regulator activity
H	0019209	molecular_function	kinase activator activity
H	0019221	biological_process	cytokine-mediated signaling pathway
H	0019903	molecular_function	protein phosphatase binding
H	0030183	biological_process	B cell differentiation
H	0030217	biological_process	T cell differentiation
H	0030316	biological_process	osteoclast differentiation
H	0032760	biological_process	positive regulation of tumor necrosis factor production
H	0032869	biological_process	cellular response to insulin stimulus
H	0033120	biological_process	positive regulation of RNA splicing
H	0034143	biological_process	regulation of toll-like receptor 4 signaling pathway
H	0034446	biological_process	substrate adhesion-dependent cell spreading
H	0034644	biological_process	cellular response to UV
H	0034976	biological_process	response to endoplasmic reticulum stress
H	0035014	molecular_function	phosphatidylinositol 3-kinase regulator activity
H	0035655	biological_process	interleukin-18-mediated signaling pathway
H	0036312	molecular_function	phosphatidylinositol 3-kinase regulatory subunit binding
H	0042267	biological_process	natural killer cell mediated cytotoxicity
H	0042307	biological_process	positive regulation of protein import into nucleus
H	0043066	biological_process	negative regulation of apoptotic process
H	0043125	molecular_function	ErbB-3 class receptor binding
H	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
H	0043548	molecular_function	phosphatidylinositol 3-kinase binding
H	0043559	molecular_function	insulin binding
H	0043560	molecular_function	insulin receptor substrate binding
H	0045671	biological_process	negative regulation of osteoclast differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046326	biological_process	positive regulation of D-glucose import
H	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
H	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
H	0046982	molecular_function	protein heterodimerization activity
H	0048009	biological_process	insulin-like growth factor receptor signaling pathway
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0048661	biological_process	positive regulation of smooth muscle cell proliferation
H	0050821	biological_process	protein stabilization
H	0051491	biological_process	positive regulation of filopodium assembly
H	0051492	biological_process	regulation of stress fiber assembly
H	0051497	biological_process	negative regulation of stress fiber assembly
H	0052742	molecular_function	phosphatidylinositol kinase activity
H	0060396	biological_process	growth hormone receptor signaling pathway
H	0061470	biological_process	T follicular helper cell differentiation
H	0097529	biological_process	myeloid leukocyte migration
H	0120183	biological_process	positive regulation of focal adhesion disassembly
H	0140767	molecular_function	enzyme-substrate adaptor activity
H	0141038	molecular_function	phosphatidylinositol 3-kinase activator activity
H	1900103	biological_process	positive regulation of endoplasmic reticulum unfolded protein response
H	1903076	biological_process	regulation of protein localization to plasma membrane
H	1903078	biological_process	positive regulation of protein localization to plasma membrane
H	1990578	cellular_component	perinuclear endoplasmic reticulum membrane
I	0001678	biological_process	intracellular glucose homeostasis
I	0001784	molecular_function	phosphotyrosine residue binding
I	0001953	biological_process	negative regulation of cell-matrix adhesion
I	0002687	biological_process	positive regulation of leukocyte migration
I	0005068	molecular_function	transmembrane receptor protein tyrosine kinase adaptor activity
I	0005096	molecular_function	GTPase activator activity
I	0005158	molecular_function	insulin receptor binding
I	0005159	molecular_function	insulin-like growth factor receptor binding
I	0005168	molecular_function	neurotrophin TRKA receptor binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005801	cellular_component	cis-Golgi network
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005911	cellular_component	cell-cell junction
I	0005942	cellular_component	phosphatidylinositol 3-kinase complex
I	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
I	0006366	biological_process	transcription by RNA polymerase II
I	0006606	biological_process	protein import into nucleus
I	0006955	biological_process	immune response
I	0007162	biological_process	negative regulation of cell adhesion
I	0007165	biological_process	signal transduction
I	0008286	biological_process	insulin receptor signaling pathway
I	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
I	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
I	0010592	biological_process	positive regulation of lamellipodium assembly
I	0015031	biological_process	protein transport
I	0016020	cellular_component	membrane
I	0019207	molecular_function	kinase regulator activity
I	0019209	molecular_function	kinase activator activity
I	0019221	biological_process	cytokine-mediated signaling pathway
I	0019903	molecular_function	protein phosphatase binding
I	0030183	biological_process	B cell differentiation
I	0030217	biological_process	T cell differentiation
I	0030316	biological_process	osteoclast differentiation
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0032869	biological_process	cellular response to insulin stimulus
I	0033120	biological_process	positive regulation of RNA splicing
I	0034143	biological_process	regulation of toll-like receptor 4 signaling pathway
I	0034446	biological_process	substrate adhesion-dependent cell spreading
I	0034644	biological_process	cellular response to UV
I	0034976	biological_process	response to endoplasmic reticulum stress
I	0035014	molecular_function	phosphatidylinositol 3-kinase regulator activity
I	0035655	biological_process	interleukin-18-mediated signaling pathway
I	0036312	molecular_function	phosphatidylinositol 3-kinase regulatory subunit binding
I	0042267	biological_process	natural killer cell mediated cytotoxicity
I	0042307	biological_process	positive regulation of protein import into nucleus
I	0043066	biological_process	negative regulation of apoptotic process
I	0043125	molecular_function	ErbB-3 class receptor binding
I	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
I	0043548	molecular_function	phosphatidylinositol 3-kinase binding
I	0043559	molecular_function	insulin binding
I	0043560	molecular_function	insulin receptor substrate binding
I	0045671	biological_process	negative regulation of osteoclast differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046326	biological_process	positive regulation of D-glucose import
I	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
I	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
I	0046982	molecular_function	protein heterodimerization activity
I	0048009	biological_process	insulin-like growth factor receptor signaling pathway
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0048661	biological_process	positive regulation of smooth muscle cell proliferation
I	0050821	biological_process	protein stabilization
I	0051491	biological_process	positive regulation of filopodium assembly
I	0051492	biological_process	regulation of stress fiber assembly
I	0051497	biological_process	negative regulation of stress fiber assembly
I	0052742	molecular_function	phosphatidylinositol kinase activity
I	0060396	biological_process	growth hormone receptor signaling pathway
I	0061470	biological_process	T follicular helper cell differentiation
I	0097529	biological_process	myeloid leukocyte migration
I	0120183	biological_process	positive regulation of focal adhesion disassembly
I	0140767	molecular_function	enzyme-substrate adaptor activity
I	0141038	molecular_function	phosphatidylinositol 3-kinase activator activity
I	1900103	biological_process	positive regulation of endoplasmic reticulum unfolded protein response
I	1903076	biological_process	regulation of protein localization to plasma membrane
I	1903078	biological_process	positive regulation of protein localization to plasma membrane
I	1990578	cellular_component	perinuclear endoplasmic reticulum membrane
J	0001678	biological_process	intracellular glucose homeostasis
J	0001784	molecular_function	phosphotyrosine residue binding
J	0001953	biological_process	negative regulation of cell-matrix adhesion
J	0002687	biological_process	positive regulation of leukocyte migration
J	0005068	molecular_function	transmembrane receptor protein tyrosine kinase adaptor activity
J	0005096	molecular_function	GTPase activator activity
J	0005158	molecular_function	insulin receptor binding
J	0005159	molecular_function	insulin-like growth factor receptor binding
J	0005168	molecular_function	neurotrophin TRKA receptor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005801	cellular_component	cis-Golgi network
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005911	cellular_component	cell-cell junction
J	0005942	cellular_component	phosphatidylinositol 3-kinase complex
J	0005943	cellular_component	phosphatidylinositol 3-kinase complex, class IA
J	0006366	biological_process	transcription by RNA polymerase II
J	0006606	biological_process	protein import into nucleus
J	0006955	biological_process	immune response
J	0007162	biological_process	negative regulation of cell adhesion
J	0007165	biological_process	signal transduction
J	0008286	biological_process	insulin receptor signaling pathway
J	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
J	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
J	0010592	biological_process	positive regulation of lamellipodium assembly
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0019207	molecular_function	kinase regulator activity
J	0019209	molecular_function	kinase activator activity
J	0019221	biological_process	cytokine-mediated signaling pathway
J	0019903	molecular_function	protein phosphatase binding
J	0030183	biological_process	B cell differentiation
J	0030217	biological_process	T cell differentiation
J	0030316	biological_process	osteoclast differentiation
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0032869	biological_process	cellular response to insulin stimulus
J	0033120	biological_process	positive regulation of RNA splicing
J	0034143	biological_process	regulation of toll-like receptor 4 signaling pathway
J	0034446	biological_process	substrate adhesion-dependent cell spreading
J	0034644	biological_process	cellular response to UV
J	0034976	biological_process	response to endoplasmic reticulum stress
J	0035014	molecular_function	phosphatidylinositol 3-kinase regulator activity
J	0035655	biological_process	interleukin-18-mediated signaling pathway
J	0036312	molecular_function	phosphatidylinositol 3-kinase regulatory subunit binding
J	0042267	biological_process	natural killer cell mediated cytotoxicity
J	0042307	biological_process	positive regulation of protein import into nucleus
J	0043066	biological_process	negative regulation of apoptotic process
J	0043125	molecular_function	ErbB-3 class receptor binding
J	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
J	0043548	molecular_function	phosphatidylinositol 3-kinase binding
J	0043559	molecular_function	insulin binding
J	0043560	molecular_function	insulin receptor substrate binding
J	0045671	biological_process	negative regulation of osteoclast differentiation
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046326	biological_process	positive regulation of D-glucose import
J	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
J	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity
J	0046982	molecular_function	protein heterodimerization activity
J	0048009	biological_process	insulin-like growth factor receptor signaling pathway
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0048661	biological_process	positive regulation of smooth muscle cell proliferation
J	0050821	biological_process	protein stabilization
J	0051491	biological_process	positive regulation of filopodium assembly
J	0051492	biological_process	regulation of stress fiber assembly
J	0051497	biological_process	negative regulation of stress fiber assembly
J	0052742	molecular_function	phosphatidylinositol kinase activity
J	0060396	biological_process	growth hormone receptor signaling pathway
J	0061470	biological_process	T follicular helper cell differentiation
J	0097529	biological_process	myeloid leukocyte migration
J	0120183	biological_process	positive regulation of focal adhesion disassembly
J	0140767	molecular_function	enzyme-substrate adaptor activity
J	0141038	molecular_function	phosphatidylinositol 3-kinase activator activity
J	1900103	biological_process	positive regulation of endoplasmic reticulum unfolded protein response
J	1903076	biological_process	regulation of protein localization to plasma membrane
J	1903078	biological_process	positive regulation of protein localization to plasma membrane
J	1990578	cellular_component	perinuclear endoplasmic reticulum membrane
M	0000082	biological_process	G1/S transition of mitotic cell cycle
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000209	biological_process	protein polyubiquitination
M	0000278	biological_process	mitotic cell cycle
M	0000902	biological_process	cell morphogenesis
M	0000922	cellular_component	spindle pole
M	0001701	biological_process	in utero embryonic development
M	0001822	biological_process	kidney development
M	0001831	biological_process	trophectodermal cellular morphogenesis
M	0004842	molecular_function	ubiquitin-protein transferase activity
M	0005112	molecular_function	Notch binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005794	cellular_component	Golgi apparatus
M	0005813	cellular_component	centrosome
M	0005819	cellular_component	spindle
M	0005827	cellular_component	polar microtubule
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0005929	cellular_component	cilium
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006366	biological_process	transcription by RNA polymerase II
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0006513	biological_process	protein monoubiquitination
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
M	0006915	biological_process	apoptotic process
M	0006950	biological_process	response to stress
M	0006954	biological_process	inflammatory response
M	0006979	biological_process	response to oxidative stress
M	0007080	biological_process	mitotic metaphase chromosome alignment
M	0007165	biological_process	signal transduction
M	0007229	biological_process	integrin-mediated signaling pathway
M	0007369	biological_process	gastrulation
M	0008284	biological_process	positive regulation of cell population proliferation
M	0010467	biological_process	gene expression
M	0010468	biological_process	regulation of gene expression
M	0010558	biological_process	negative regulation of macromolecule biosynthetic process
M	0016020	cellular_component	membrane
M	0016055	biological_process	Wnt signaling pathway
M	0016192	biological_process	vesicle-mediated transport
M	0016477	biological_process	cell migration
M	0016567	biological_process	protein ubiquitination
M	0017145	biological_process	stem cell division
M	0030030	biological_process	cell projection organization
M	0030163	biological_process	protein catabolic process
M	0030332	molecular_function	cyclin binding
M	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
M	0031208	molecular_function	POZ domain binding
M	0031398	biological_process	positive regulation of protein ubiquitination
M	0031461	cellular_component	cullin-RING ubiquitin ligase complex
M	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
M	0031514	cellular_component	motile cilium
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0031648	biological_process	protein destabilization
M	0031669	biological_process	cellular response to nutrient levels
M	0032467	biological_process	positive regulation of cytokinesis
M	0032480	biological_process	negative regulation of type I interferon production
M	0032481	biological_process	positive regulation of type I interferon production
M	0032869	biological_process	cellular response to insulin stimulus
M	0034198	biological_process	cellular response to amino acid starvation
M	0034599	biological_process	cellular response to oxidative stress
M	0035024	biological_process	negative regulation of Rho protein signal transduction
M	0036126	cellular_component	sperm flagellum
M	0040016	biological_process	embryonic cleavage
M	0042802	molecular_function	identical protein binding
M	0042995	cellular_component	cell projection
M	0043149	biological_process	stress fiber assembly
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0044346	biological_process	fibroblast apoptotic process
M	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
M	0048208	biological_process	COPII vesicle coating
M	0051301	biological_process	cell division
M	0051865	biological_process	protein autoubiquitination
M	0060337	biological_process	type I interferon-mediated signaling pathway
M	0061630	molecular_function	ubiquitin protein ligase activity
M	0070062	cellular_component	extracellular exosome
M	0070294	biological_process	renal sodium ion absorption
M	0070936	biological_process	protein K48-linked ubiquitination
M	0071230	biological_process	cellular response to amino acid stimulus
M	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
M	0072576	biological_process	liver morphogenesis
M	0072686	cellular_component	mitotic spindle
M	0080090	biological_process	regulation of primary metabolic process
M	0097193	biological_process	intrinsic apoptotic signaling pathway
M	0098794	cellular_component	postsynapse
M	0098978	cellular_component	glutamatergic synapse
M	0140252	biological_process	regulation protein catabolic process at postsynapse
M	0160072	molecular_function	ubiquitin ligase complex scaffold activity
M	0160240	biological_process	RNA polymerase II transcription initiation surveillance
M	1900076	biological_process	regulation of cellular response to insulin stimulus
M	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
M	1904262	biological_process	negative regulation of TORC1 signaling
M	1904263	biological_process	positive regulation of TORC1 signaling
N	0005737	cellular_component	cytoplasm
N	0006006	biological_process	glucose metabolic process
N	0006629	biological_process	lipid metabolic process
N	0010467	biological_process	gene expression
N	0016567	biological_process	protein ubiquitination
N	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
N	0032868	biological_process	response to insulin
N	0032869	biological_process	cellular response to insulin stimulus
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
N	0070936	biological_process	protein K48-linked ubiquitination
N	1900076	biological_process	regulation of cellular response to insulin stimulus
N	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0000209	biological_process	protein polyubiquitination
O	0000278	biological_process	mitotic cell cycle
O	0000902	biological_process	cell morphogenesis
O	0000922	cellular_component	spindle pole
O	0001701	biological_process	in utero embryonic development
O	0001822	biological_process	kidney development
O	0001831	biological_process	trophectodermal cellular morphogenesis
O	0004842	molecular_function	ubiquitin-protein transferase activity
O	0005112	molecular_function	Notch binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005794	cellular_component	Golgi apparatus
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005827	cellular_component	polar microtubule
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005886	cellular_component	plasma membrane
O	0005929	cellular_component	cilium
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006366	biological_process	transcription by RNA polymerase II
O	0006368	biological_process	transcription elongation by RNA polymerase II
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006513	biological_process	protein monoubiquitination
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
O	0006915	biological_process	apoptotic process
O	0006950	biological_process	response to stress
O	0006954	biological_process	inflammatory response
O	0006979	biological_process	response to oxidative stress
O	0007080	biological_process	mitotic metaphase chromosome alignment
O	0007165	biological_process	signal transduction
O	0007229	biological_process	integrin-mediated signaling pathway
O	0007369	biological_process	gastrulation
O	0008284	biological_process	positive regulation of cell population proliferation
O	0010467	biological_process	gene expression
O	0010468	biological_process	regulation of gene expression
O	0010558	biological_process	negative regulation of macromolecule biosynthetic process
O	0016020	cellular_component	membrane
O	0016055	biological_process	Wnt signaling pathway
O	0016192	biological_process	vesicle-mediated transport
O	0016477	biological_process	cell migration
O	0016567	biological_process	protein ubiquitination
O	0017145	biological_process	stem cell division
O	0030030	biological_process	cell projection organization
O	0030163	biological_process	protein catabolic process
O	0030332	molecular_function	cyclin binding
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0031208	molecular_function	POZ domain binding
O	0031398	biological_process	positive regulation of protein ubiquitination
O	0031461	cellular_component	cullin-RING ubiquitin ligase complex
O	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
O	0031514	cellular_component	motile cilium
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0031648	biological_process	protein destabilization
O	0031669	biological_process	cellular response to nutrient levels
O	0032467	biological_process	positive regulation of cytokinesis
O	0032480	biological_process	negative regulation of type I interferon production
O	0032481	biological_process	positive regulation of type I interferon production
O	0032869	biological_process	cellular response to insulin stimulus
O	0034198	biological_process	cellular response to amino acid starvation
O	0034599	biological_process	cellular response to oxidative stress
O	0035024	biological_process	negative regulation of Rho protein signal transduction
O	0036126	cellular_component	sperm flagellum
O	0040016	biological_process	embryonic cleavage
O	0042802	molecular_function	identical protein binding
O	0042995	cellular_component	cell projection
O	0043149	biological_process	stress fiber assembly
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0044346	biological_process	fibroblast apoptotic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0048208	biological_process	COPII vesicle coating
O	0051301	biological_process	cell division
O	0051865	biological_process	protein autoubiquitination
O	0060337	biological_process	type I interferon-mediated signaling pathway
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0070062	cellular_component	extracellular exosome
O	0070294	biological_process	renal sodium ion absorption
O	0070936	biological_process	protein K48-linked ubiquitination
O	0071230	biological_process	cellular response to amino acid stimulus
O	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
O	0072576	biological_process	liver morphogenesis
O	0072686	cellular_component	mitotic spindle
O	0080090	biological_process	regulation of primary metabolic process
O	0097193	biological_process	intrinsic apoptotic signaling pathway
O	0098794	cellular_component	postsynapse
O	0098978	cellular_component	glutamatergic synapse
O	0140252	biological_process	regulation protein catabolic process at postsynapse
O	0160072	molecular_function	ubiquitin ligase complex scaffold activity
O	0160240	biological_process	RNA polymerase II transcription initiation surveillance
O	1900076	biological_process	regulation of cellular response to insulin stimulus
O	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
O	1904262	biological_process	negative regulation of TORC1 signaling
O	1904263	biological_process	positive regulation of TORC1 signaling
P	0005737	cellular_component	cytoplasm
P	0006006	biological_process	glucose metabolic process
P	0006629	biological_process	lipid metabolic process
P	0010467	biological_process	gene expression
P	0016567	biological_process	protein ubiquitination
P	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
P	0032868	biological_process	response to insulin
P	0032869	biological_process	cellular response to insulin stimulus
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
P	0070936	biological_process	protein K48-linked ubiquitination
P	1900076	biological_process	regulation of cellular response to insulin stimulus
P	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
Q	0000045	biological_process	autophagosome assembly
Q	0000082	biological_process	G1/S transition of mitotic cell cycle
Q	0000165	biological_process	MAPK cascade
Q	0000209	biological_process	protein polyubiquitination
Q	0000423	biological_process	mitophagy
Q	0001837	biological_process	epithelial to mesenchymal transition
Q	0004842	molecular_function	ubiquitin-protein transferase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006281	biological_process	DNA repair
Q	0006283	biological_process	transcription-coupled nucleotide-excision repair
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006513	biological_process	protein monoubiquitination
Q	0006915	biological_process	apoptotic process
Q	0006974	biological_process	DNA damage response
Q	0006979	biological_process	response to oxidative stress
Q	0007040	biological_process	lysosome organization
Q	0007283	biological_process	spermatogenesis
Q	0007346	biological_process	regulation of mitotic cell cycle
Q	0008270	molecular_function	zinc ion binding
Q	0008286	biological_process	insulin receptor signaling pathway
Q	0010507	biological_process	negative regulation of autophagy
Q	0010508	biological_process	positive regulation of autophagy
Q	0016567	biological_process	protein ubiquitination
Q	0016740	molecular_function	transferase activity
Q	0019005	cellular_component	SCF ubiquitin ligase complex
Q	0019221	biological_process	cytokine-mediated signaling pathway
Q	0019788	molecular_function	NEDD8 transferase activity
Q	0030163	biological_process	protein catabolic process
Q	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
Q	0030891	cellular_component	VCB complex
Q	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Q	0031461	cellular_component	cullin-RING ubiquitin ligase complex
Q	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
Q	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
Q	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
Q	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
Q	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
Q	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0031669	biological_process	cellular response to nutrient levels
Q	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Q	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Q	0032480	biological_process	negative regulation of type I interferon production
Q	0032481	biological_process	positive regulation of type I interferon production
Q	0032869	biological_process	cellular response to insulin stimulus
Q	0034198	biological_process	cellular response to amino acid starvation
Q	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
Q	0034599	biological_process	cellular response to oxidative stress
Q	0034644	biological_process	cellular response to UV
Q	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
Q	0038066	biological_process	p38MAPK cascade
Q	0038202	biological_process	TORC1 signaling
Q	0042110	biological_process	T cell activation
Q	0042770	biological_process	signal transduction in response to DNA damage
Q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
Q	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043687	biological_process	post-translational protein modification
Q	0044877	molecular_function	protein-containing complex binding
Q	0045116	biological_process	protein neddylation
Q	0045727	biological_process	positive regulation of translation
Q	0045732	biological_process	positive regulation of protein catabolic process
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046627	biological_process	negative regulation of insulin receptor signaling pathway
Q	0046872	molecular_function	metal ion binding
Q	0060090	molecular_function	molecular adaptor activity
Q	0060337	biological_process	type I interferon-mediated signaling pathway
Q	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
Q	0061630	molecular_function	ubiquitin protein ligase activity
Q	0061663	molecular_function	NEDD8 ligase activity
Q	0062197	biological_process	cellular response to chemical stress
Q	0070294	biological_process	renal sodium ion absorption
Q	0070936	biological_process	protein K48-linked ubiquitination
Q	0071230	biological_process	cellular response to amino acid stimulus
Q	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
Q	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
Q	0090734	cellular_component	site of DNA damage
Q	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
Q	0097602	molecular_function	cullin family protein binding
Q	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Q	0160240	biological_process	RNA polymerase II transcription initiation surveillance
Q	1900076	biological_process	regulation of cellular response to insulin stimulus
Q	1901525	biological_process	negative regulation of mitophagy
Q	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
Q	1902499	biological_process	positive regulation of protein autoubiquitination
Q	1902883	biological_process	negative regulation of response to oxidative stress
Q	1904037	biological_process	positive regulation of epithelial cell apoptotic process
Q	1904262	biological_process	negative regulation of TORC1 signaling
Q	1904263	biological_process	positive regulation of TORC1 signaling
Q	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
R	0000045	biological_process	autophagosome assembly
R	0000082	biological_process	G1/S transition of mitotic cell cycle
R	0000165	biological_process	MAPK cascade
R	0000209	biological_process	protein polyubiquitination
R	0000423	biological_process	mitophagy
R	0001837	biological_process	epithelial to mesenchymal transition
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006283	biological_process	transcription-coupled nucleotide-excision repair
R	0006366	biological_process	transcription by RNA polymerase II
R	0006368	biological_process	transcription elongation by RNA polymerase II
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006513	biological_process	protein monoubiquitination
R	0006915	biological_process	apoptotic process
R	0006974	biological_process	DNA damage response
R	0006979	biological_process	response to oxidative stress
R	0007040	biological_process	lysosome organization
R	0007283	biological_process	spermatogenesis
R	0007346	biological_process	regulation of mitotic cell cycle
R	0008270	molecular_function	zinc ion binding
R	0008286	biological_process	insulin receptor signaling pathway
R	0010507	biological_process	negative regulation of autophagy
R	0010508	biological_process	positive regulation of autophagy
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019005	cellular_component	SCF ubiquitin ligase complex
R	0019221	biological_process	cytokine-mediated signaling pathway
R	0019788	molecular_function	NEDD8 transferase activity
R	0030163	biological_process	protein catabolic process
R	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
R	0030891	cellular_component	VCB complex
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0031669	biological_process	cellular response to nutrient levels
R	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032480	biological_process	negative regulation of type I interferon production
R	0032481	biological_process	positive regulation of type I interferon production
R	0032869	biological_process	cellular response to insulin stimulus
R	0034198	biological_process	cellular response to amino acid starvation
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0034599	biological_process	cellular response to oxidative stress
R	0034644	biological_process	cellular response to UV
R	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
R	0038066	biological_process	p38MAPK cascade
R	0038202	biological_process	TORC1 signaling
R	0042110	biological_process	T cell activation
R	0042770	biological_process	signal transduction in response to DNA damage
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0044877	molecular_function	protein-containing complex binding
R	0045116	biological_process	protein neddylation
R	0045727	biological_process	positive regulation of translation
R	0045732	biological_process	positive regulation of protein catabolic process
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046627	biological_process	negative regulation of insulin receptor signaling pathway
R	0046872	molecular_function	metal ion binding
R	0060090	molecular_function	molecular adaptor activity
R	0060337	biological_process	type I interferon-mediated signaling pathway
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0062197	biological_process	cellular response to chemical stress
R	0070294	biological_process	renal sodium ion absorption
R	0070936	biological_process	protein K48-linked ubiquitination
R	0071230	biological_process	cellular response to amino acid stimulus
R	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
R	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
R	0090734	cellular_component	site of DNA damage
R	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
R	0097602	molecular_function	cullin family protein binding
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	0160240	biological_process	RNA polymerase II transcription initiation surveillance
R	1900076	biological_process	regulation of cellular response to insulin stimulus
R	1901525	biological_process	negative regulation of mitophagy
R	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
R	1902499	biological_process	positive regulation of protein autoubiquitination
R	1902883	biological_process	negative regulation of response to oxidative stress
R	1904037	biological_process	positive regulation of epithelial cell apoptotic process
R	1904262	biological_process	negative regulation of TORC1 signaling
R	1904263	biological_process	positive regulation of TORC1 signaling
R	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA

Chain	Residue	Details
C	ILE741-ALA768

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
G	SER2
H	SER2
I	SER2
J	SER2

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER154
D	CYS75
D	HIS77
D	HIS80
D	CYS94
D	ASP97
R	CYS42
R	CYS45
R	CYS75
R	HIS77
R	HIS80
G	SER279
R	CYS94
R	ASP97
Q	CYS42
Q	CYS45
Q	CYS75
Q	HIS77
Q	HIS80
Q	CYS94
Q	ASP97
H	SER154
H	SER279
I	SER154
I	SER279
J	SER154
J	SER279
D	CYS45

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P26450

Chain	Residue	Details
G	TYR467
R	CYS56
R	CYS68
R	HIS82
Q	CYS53
Q	CYS56
Q	CYS68
Q	HIS82
H	TYR467
I	TYR467
J	TYR467
D	CYS53
D	CYS56
D	CYS68
D	HIS82
R	CYS53

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
G	TYR580
H	TYR580
I	TYR580
J	TYR580

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23727

Chain	Residue	Details
G	SER608
H	SER608
I	SER608
J	SER608

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
E	ALA2
D	ALA2
R	ALA2
Q	ALA2

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	THR9
D	THR9
R	THR9
Q	THR9

---