8H34

Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006006	biological_process	glucose metabolic process
A	0006629	biological_process	lipid metabolic process
A	0010467	biological_process	gene expression
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0032868	biological_process	response to insulin
A	0032869	biological_process	cellular response to insulin stimulus
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0070936	biological_process	protein K48-linked ubiquitination
A	1900076	biological_process	regulation of cellular response to insulin stimulus
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0005737	cellular_component	cytoplasm
B	0006006	biological_process	glucose metabolic process
B	0006629	biological_process	lipid metabolic process
B	0010467	biological_process	gene expression
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0032868	biological_process	response to insulin
B	0032869	biological_process	cellular response to insulin stimulus
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0070936	biological_process	protein K48-linked ubiquitination
B	1900076	biological_process	regulation of cellular response to insulin stimulus
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000209	biological_process	protein polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0000902	biological_process	cell morphogenesis
C	0000922	cellular_component	spindle pole
C	0001701	biological_process	in utero embryonic development
C	0001822	biological_process	kidney development
C	0001831	biological_process	trophectodermal cellular morphogenesis
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005827	cellular_component	polar microtubule
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006366	biological_process	transcription by RNA polymerase II
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0006954	biological_process	inflammatory response
C	0006979	biological_process	response to oxidative stress
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007165	biological_process	signal transduction
C	0007229	biological_process	integrin-mediated signaling pathway
C	0007369	biological_process	gastrulation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010467	biological_process	gene expression
C	0010468	biological_process	regulation of gene expression
C	0010558	biological_process	negative regulation of macromolecule biosynthetic process
C	0016020	cellular_component	membrane
C	0016055	biological_process	Wnt signaling pathway
C	0016192	biological_process	vesicle-mediated transport
C	0016477	biological_process	cell migration
C	0016567	biological_process	protein ubiquitination
C	0017145	biological_process	stem cell division
C	0030030	biological_process	cell projection organization
C	0030163	biological_process	protein catabolic process
C	0030332	molecular_function	cyclin binding
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0031208	molecular_function	POZ domain binding
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031514	cellular_component	motile cilium
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031648	biological_process	protein destabilization
C	0031669	biological_process	cellular response to nutrient levels
C	0032467	biological_process	positive regulation of cytokinesis
C	0032480	biological_process	negative regulation of type I interferon production
C	0032481	biological_process	positive regulation of type I interferon production
C	0032869	biological_process	cellular response to insulin stimulus
C	0034198	biological_process	cellular response to amino acid starvation
C	0034599	biological_process	cellular response to oxidative stress
C	0035024	biological_process	negative regulation of Rho protein signal transduction
C	0036126	cellular_component	sperm flagellum
C	0040016	biological_process	embryonic cleavage
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044346	biological_process	fibroblast apoptotic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0048208	biological_process	COPII vesicle coating
C	0051301	biological_process	cell division
C	0051865	biological_process	protein autoubiquitination
C	0060337	biological_process	type I interferon-mediated signaling pathway
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070062	cellular_component	extracellular exosome
C	0070294	biological_process	renal sodium ion absorption
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
C	0072576	biological_process	liver morphogenesis
C	0072686	cellular_component	mitotic spindle
C	0080090	biological_process	regulation of primary metabolic process
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0140252	biological_process	regulation protein catabolic process at postsynapse
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0000045	biological_process	autophagosome assembly
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0000423	biological_process	mitophagy
D	0001837	biological_process	epithelial to mesenchymal transition
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0007040	biological_process	lysosome organization
D	0007283	biological_process	spermatogenesis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008270	molecular_function	zinc ion binding
D	0008286	biological_process	insulin receptor signaling pathway
D	0010507	biological_process	negative regulation of autophagy
D	0010508	biological_process	positive regulation of autophagy
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0032481	biological_process	positive regulation of type I interferon production
D	0032869	biological_process	cellular response to insulin stimulus
D	0034198	biological_process	cellular response to amino acid starvation
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
D	0038066	biological_process	p38MAPK cascade
D	0038202	biological_process	TORC1 signaling
D	0042110	biological_process	T cell activation
D	0042770	biological_process	signal transduction in response to DNA damage
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045727	biological_process	positive regulation of translation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070294	biological_process	renal sodium ion absorption
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901525	biological_process	negative regulation of mitophagy
D	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904037	biological_process	positive regulation of epithelial cell apoptotic process
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
D	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
E	0000045	biological_process	autophagosome assembly
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000165	biological_process	MAPK cascade
E	0000209	biological_process	protein polyubiquitination
E	0000423	biological_process	mitophagy
E	0001837	biological_process	epithelial to mesenchymal transition
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006283	biological_process	transcription-coupled nucleotide-excision repair
E	0006366	biological_process	transcription by RNA polymerase II
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006513	biological_process	protein monoubiquitination
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007040	biological_process	lysosome organization
E	0007283	biological_process	spermatogenesis
E	0007346	biological_process	regulation of mitotic cell cycle
E	0008270	molecular_function	zinc ion binding
E	0008286	biological_process	insulin receptor signaling pathway
E	0010507	biological_process	negative regulation of autophagy
E	0010508	biological_process	positive regulation of autophagy
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0019788	molecular_function	NEDD8 transferase activity
E	0030163	biological_process	protein catabolic process
E	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
E	0030891	cellular_component	VCB complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032480	biological_process	negative regulation of type I interferon production
E	0032481	biological_process	positive regulation of type I interferon production
E	0032869	biological_process	cellular response to insulin stimulus
E	0034198	biological_process	cellular response to amino acid starvation
E	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034644	biological_process	cellular response to UV
E	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
E	0038066	biological_process	p38MAPK cascade
E	0038202	biological_process	TORC1 signaling
E	0042110	biological_process	T cell activation
E	0042770	biological_process	signal transduction in response to DNA damage
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043687	biological_process	post-translational protein modification
E	0044877	molecular_function	protein-containing complex binding
E	0045116	biological_process	protein neddylation
E	0045727	biological_process	positive regulation of translation
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046627	biological_process	negative regulation of insulin receptor signaling pathway
E	0046872	molecular_function	metal ion binding
E	0060090	molecular_function	molecular adaptor activity
E	0060337	biological_process	type I interferon-mediated signaling pathway
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061663	molecular_function	NEDD8 ligase activity
E	0062197	biological_process	cellular response to chemical stress
E	0070294	biological_process	renal sodium ion absorption
E	0070936	biological_process	protein K48-linked ubiquitination
E	0071230	biological_process	cellular response to amino acid stimulus
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090734	cellular_component	site of DNA damage
E	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
E	0097602	molecular_function	cullin family protein binding
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	1900076	biological_process	regulation of cellular response to insulin stimulus
E	1901525	biological_process	negative regulation of mitophagy
E	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
E	1902499	biological_process	positive regulation of protein autoubiquitination
E	1902883	biological_process	negative regulation of response to oxidative stress
E	1904037	biological_process	positive regulation of epithelial cell apoptotic process
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
E	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000209	biological_process	protein polyubiquitination
F	0000278	biological_process	mitotic cell cycle
F	0000902	biological_process	cell morphogenesis
F	0000922	cellular_component	spindle pole
F	0001701	biological_process	in utero embryonic development
F	0001822	biological_process	kidney development
F	0001831	biological_process	trophectodermal cellular morphogenesis
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005112	molecular_function	Notch binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005827	cellular_component	polar microtubule
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006513	biological_process	protein monoubiquitination
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006915	biological_process	apoptotic process
F	0006950	biological_process	response to stress
F	0006954	biological_process	inflammatory response
F	0006979	biological_process	response to oxidative stress
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0007165	biological_process	signal transduction
F	0007229	biological_process	integrin-mediated signaling pathway
F	0007369	biological_process	gastrulation
F	0008284	biological_process	positive regulation of cell population proliferation
F	0010467	biological_process	gene expression
F	0010468	biological_process	regulation of gene expression
F	0010558	biological_process	negative regulation of macromolecule biosynthetic process
F	0016020	cellular_component	membrane
F	0016055	biological_process	Wnt signaling pathway
F	0016192	biological_process	vesicle-mediated transport
F	0016477	biological_process	cell migration
F	0016567	biological_process	protein ubiquitination
F	0017145	biological_process	stem cell division
F	0030030	biological_process	cell projection organization
F	0030163	biological_process	protein catabolic process
F	0030332	molecular_function	cyclin binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0031208	molecular_function	POZ domain binding
F	0031398	biological_process	positive regulation of protein ubiquitination
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
F	0031514	cellular_component	motile cilium
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031648	biological_process	protein destabilization
F	0031669	biological_process	cellular response to nutrient levels
F	0032467	biological_process	positive regulation of cytokinesis
F	0032480	biological_process	negative regulation of type I interferon production
F	0032481	biological_process	positive regulation of type I interferon production
F	0032869	biological_process	cellular response to insulin stimulus
F	0034198	biological_process	cellular response to amino acid starvation
F	0034599	biological_process	cellular response to oxidative stress
F	0035024	biological_process	negative regulation of Rho protein signal transduction
F	0036126	cellular_component	sperm flagellum
F	0040016	biological_process	embryonic cleavage
F	0042802	molecular_function	identical protein binding
F	0042995	cellular_component	cell projection
F	0043149	biological_process	stress fiber assembly
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0044346	biological_process	fibroblast apoptotic process
F	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
F	0048208	biological_process	COPII vesicle coating
F	0051301	biological_process	cell division
F	0051865	biological_process	protein autoubiquitination
F	0060337	biological_process	type I interferon-mediated signaling pathway
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0070062	cellular_component	extracellular exosome
F	0070294	biological_process	renal sodium ion absorption
F	0070936	biological_process	protein K48-linked ubiquitination
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
F	0072576	biological_process	liver morphogenesis
F	0072686	cellular_component	mitotic spindle
F	0080090	biological_process	regulation of primary metabolic process
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0140252	biological_process	regulation protein catabolic process at postsynapse
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	0160240	biological_process	RNA polymerase II transcription initiation surveillance
F	1900076	biological_process	regulation of cellular response to insulin stimulus
F	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0005737	cellular_component	cytoplasm
G	0006006	biological_process	glucose metabolic process
G	0006629	biological_process	lipid metabolic process
G	0010467	biological_process	gene expression
G	0016567	biological_process	protein ubiquitination
G	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
G	0032868	biological_process	response to insulin
G	0032869	biological_process	cellular response to insulin stimulus
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0070936	biological_process	protein K48-linked ubiquitination
G	1900076	biological_process	regulation of cellular response to insulin stimulus
G	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
H	0000082	biological_process	G1/S transition of mitotic cell cycle
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000209	biological_process	protein polyubiquitination
H	0000278	biological_process	mitotic cell cycle
H	0000902	biological_process	cell morphogenesis
H	0000922	cellular_component	spindle pole
H	0001701	biological_process	in utero embryonic development
H	0001822	biological_process	kidney development
H	0001831	biological_process	trophectodermal cellular morphogenesis
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005112	molecular_function	Notch binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005827	cellular_component	polar microtubule
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005929	cellular_component	cilium
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
H	0006915	biological_process	apoptotic process
H	0006950	biological_process	response to stress
H	0006954	biological_process	inflammatory response
H	0006979	biological_process	response to oxidative stress
H	0007080	biological_process	mitotic metaphase chromosome alignment
H	0007165	biological_process	signal transduction
H	0007229	biological_process	integrin-mediated signaling pathway
H	0007369	biological_process	gastrulation
H	0008284	biological_process	positive regulation of cell population proliferation
H	0010467	biological_process	gene expression
H	0010468	biological_process	regulation of gene expression
H	0010558	biological_process	negative regulation of macromolecule biosynthetic process
H	0016020	cellular_component	membrane
H	0016055	biological_process	Wnt signaling pathway
H	0016192	biological_process	vesicle-mediated transport
H	0016477	biological_process	cell migration
H	0016567	biological_process	protein ubiquitination
H	0017145	biological_process	stem cell division
H	0030030	biological_process	cell projection organization
H	0030163	biological_process	protein catabolic process
H	0030332	molecular_function	cyclin binding
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0031208	molecular_function	POZ domain binding
H	0031398	biological_process	positive regulation of protein ubiquitination
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031514	cellular_component	motile cilium
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0031648	biological_process	protein destabilization
H	0031669	biological_process	cellular response to nutrient levels
H	0032467	biological_process	positive regulation of cytokinesis
H	0032480	biological_process	negative regulation of type I interferon production
H	0032481	biological_process	positive regulation of type I interferon production
H	0032869	biological_process	cellular response to insulin stimulus
H	0034198	biological_process	cellular response to amino acid starvation
H	0034599	biological_process	cellular response to oxidative stress
H	0035024	biological_process	negative regulation of Rho protein signal transduction
H	0036126	cellular_component	sperm flagellum
H	0040016	biological_process	embryonic cleavage
H	0042802	molecular_function	identical protein binding
H	0042995	cellular_component	cell projection
H	0043149	biological_process	stress fiber assembly
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0044346	biological_process	fibroblast apoptotic process
H	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
H	0048208	biological_process	COPII vesicle coating
H	0051301	biological_process	cell division
H	0051865	biological_process	protein autoubiquitination
H	0060337	biological_process	type I interferon-mediated signaling pathway
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070062	cellular_component	extracellular exosome
H	0070294	biological_process	renal sodium ion absorption
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
H	0072576	biological_process	liver morphogenesis
H	0072686	cellular_component	mitotic spindle
H	0080090	biological_process	regulation of primary metabolic process
H	0097193	biological_process	intrinsic apoptotic signaling pathway
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0140252	biological_process	regulation protein catabolic process at postsynapse
H	0160072	molecular_function	ubiquitin ligase complex scaffold activity
H	0160240	biological_process	RNA polymerase II transcription initiation surveillance
H	1900076	biological_process	regulation of cellular response to insulin stimulus
H	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1904263	biological_process	positive regulation of TORC1 signaling
I	0000082	biological_process	G1/S transition of mitotic cell cycle
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000209	biological_process	protein polyubiquitination
I	0000278	biological_process	mitotic cell cycle
I	0000902	biological_process	cell morphogenesis
I	0000922	cellular_component	spindle pole
I	0001701	biological_process	in utero embryonic development
I	0001822	biological_process	kidney development
I	0001831	biological_process	trophectodermal cellular morphogenesis
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005112	molecular_function	Notch binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005794	cellular_component	Golgi apparatus
I	0005813	cellular_component	centrosome
I	0005819	cellular_component	spindle
I	0005827	cellular_component	polar microtubule
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005929	cellular_component	cilium
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006366	biological_process	transcription by RNA polymerase II
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006513	biological_process	protein monoubiquitination
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
I	0006915	biological_process	apoptotic process
I	0006950	biological_process	response to stress
I	0006954	biological_process	inflammatory response
I	0006979	biological_process	response to oxidative stress
I	0007080	biological_process	mitotic metaphase chromosome alignment
I	0007165	biological_process	signal transduction
I	0007229	biological_process	integrin-mediated signaling pathway
I	0007369	biological_process	gastrulation
I	0008284	biological_process	positive regulation of cell population proliferation
I	0010467	biological_process	gene expression
I	0010468	biological_process	regulation of gene expression
I	0010558	biological_process	negative regulation of macromolecule biosynthetic process
I	0016020	cellular_component	membrane
I	0016055	biological_process	Wnt signaling pathway
I	0016192	biological_process	vesicle-mediated transport
I	0016477	biological_process	cell migration
I	0016567	biological_process	protein ubiquitination
I	0017145	biological_process	stem cell division
I	0030030	biological_process	cell projection organization
I	0030163	biological_process	protein catabolic process
I	0030332	molecular_function	cyclin binding
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0031208	molecular_function	POZ domain binding
I	0031398	biological_process	positive regulation of protein ubiquitination
I	0031461	cellular_component	cullin-RING ubiquitin ligase complex
I	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
I	0031514	cellular_component	motile cilium
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0031648	biological_process	protein destabilization
I	0031669	biological_process	cellular response to nutrient levels
I	0032467	biological_process	positive regulation of cytokinesis
I	0032480	biological_process	negative regulation of type I interferon production
I	0032481	biological_process	positive regulation of type I interferon production
I	0032869	biological_process	cellular response to insulin stimulus
I	0034198	biological_process	cellular response to amino acid starvation
I	0034599	biological_process	cellular response to oxidative stress
I	0035024	biological_process	negative regulation of Rho protein signal transduction
I	0036126	cellular_component	sperm flagellum
I	0040016	biological_process	embryonic cleavage
I	0042802	molecular_function	identical protein binding
I	0042995	cellular_component	cell projection
I	0043149	biological_process	stress fiber assembly
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0044346	biological_process	fibroblast apoptotic process
I	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
I	0048208	biological_process	COPII vesicle coating
I	0051301	biological_process	cell division
I	0051865	biological_process	protein autoubiquitination
I	0060337	biological_process	type I interferon-mediated signaling pathway
I	0061630	molecular_function	ubiquitin protein ligase activity
I	0070062	cellular_component	extracellular exosome
I	0070294	biological_process	renal sodium ion absorption
I	0070936	biological_process	protein K48-linked ubiquitination
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
I	0072576	biological_process	liver morphogenesis
I	0072686	cellular_component	mitotic spindle
I	0080090	biological_process	regulation of primary metabolic process
I	0097193	biological_process	intrinsic apoptotic signaling pathway
I	0098794	cellular_component	postsynapse
I	0098978	cellular_component	glutamatergic synapse
I	0140252	biological_process	regulation protein catabolic process at postsynapse
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity
I	0160240	biological_process	RNA polymerase II transcription initiation surveillance
I	1900076	biological_process	regulation of cellular response to insulin stimulus
I	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
I	1904262	biological_process	negative regulation of TORC1 signaling
I	1904263	biological_process	positive regulation of TORC1 signaling
J	0005737	cellular_component	cytoplasm
J	0006006	biological_process	glucose metabolic process
J	0006629	biological_process	lipid metabolic process
J	0010467	biological_process	gene expression
J	0016567	biological_process	protein ubiquitination
J	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
J	0032868	biological_process	response to insulin
J	0032869	biological_process	cellular response to insulin stimulus
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
J	0070936	biological_process	protein K48-linked ubiquitination
J	1900076	biological_process	regulation of cellular response to insulin stimulus
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	0000045	biological_process	autophagosome assembly
K	0000082	biological_process	G1/S transition of mitotic cell cycle
K	0000165	biological_process	MAPK cascade
K	0000209	biological_process	protein polyubiquitination
K	0000423	biological_process	mitophagy
K	0001837	biological_process	epithelial to mesenchymal transition
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006283	biological_process	transcription-coupled nucleotide-excision repair
K	0006366	biological_process	transcription by RNA polymerase II
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006513	biological_process	protein monoubiquitination
K	0006915	biological_process	apoptotic process
K	0006974	biological_process	DNA damage response
K	0006979	biological_process	response to oxidative stress
K	0007040	biological_process	lysosome organization
K	0007283	biological_process	spermatogenesis
K	0007346	biological_process	regulation of mitotic cell cycle
K	0008270	molecular_function	zinc ion binding
K	0008286	biological_process	insulin receptor signaling pathway
K	0010507	biological_process	negative regulation of autophagy
K	0010508	biological_process	positive regulation of autophagy
K	0016567	biological_process	protein ubiquitination
K	0016740	molecular_function	transferase activity
K	0019005	cellular_component	SCF ubiquitin ligase complex
K	0019221	biological_process	cytokine-mediated signaling pathway
K	0019788	molecular_function	NEDD8 transferase activity
K	0030163	biological_process	protein catabolic process
K	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
K	0030891	cellular_component	VCB complex
K	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
K	0031461	cellular_component	cullin-RING ubiquitin ligase complex
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
K	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
K	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
K	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0031669	biological_process	cellular response to nutrient levels
K	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0032480	biological_process	negative regulation of type I interferon production
K	0032481	biological_process	positive regulation of type I interferon production
K	0032869	biological_process	cellular response to insulin stimulus
K	0034198	biological_process	cellular response to amino acid starvation
K	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
K	0034599	biological_process	cellular response to oxidative stress
K	0034644	biological_process	cellular response to UV
K	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
K	0038066	biological_process	p38MAPK cascade
K	0038202	biological_process	TORC1 signaling
K	0042110	biological_process	T cell activation
K	0042770	biological_process	signal transduction in response to DNA damage
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043687	biological_process	post-translational protein modification
K	0044877	molecular_function	protein-containing complex binding
K	0045116	biological_process	protein neddylation
K	0045727	biological_process	positive regulation of translation
K	0045732	biological_process	positive regulation of protein catabolic process
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046627	biological_process	negative regulation of insulin receptor signaling pathway
K	0046872	molecular_function	metal ion binding
K	0060090	molecular_function	molecular adaptor activity
K	0060337	biological_process	type I interferon-mediated signaling pathway
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0061663	molecular_function	NEDD8 ligase activity
K	0062197	biological_process	cellular response to chemical stress
K	0070294	biological_process	renal sodium ion absorption
K	0070936	biological_process	protein K48-linked ubiquitination
K	0071230	biological_process	cellular response to amino acid stimulus
K	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0090734	cellular_component	site of DNA damage
K	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
K	0097602	molecular_function	cullin family protein binding
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	0160240	biological_process	RNA polymerase II transcription initiation surveillance
K	1900076	biological_process	regulation of cellular response to insulin stimulus
K	1901525	biological_process	negative regulation of mitophagy
K	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
K	1902499	biological_process	positive regulation of protein autoubiquitination
K	1902883	biological_process	negative regulation of response to oxidative stress
K	1904037	biological_process	positive regulation of epithelial cell apoptotic process
K	1904262	biological_process	negative regulation of TORC1 signaling
K	1904263	biological_process	positive regulation of TORC1 signaling
K	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
L	0000045	biological_process	autophagosome assembly
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000165	biological_process	MAPK cascade
L	0000209	biological_process	protein polyubiquitination
L	0000423	biological_process	mitophagy
L	0001837	biological_process	epithelial to mesenchymal transition
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006283	biological_process	transcription-coupled nucleotide-excision repair
L	0006366	biological_process	transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006915	biological_process	apoptotic process
L	0006974	biological_process	DNA damage response
L	0006979	biological_process	response to oxidative stress
L	0007040	biological_process	lysosome organization
L	0007283	biological_process	spermatogenesis
L	0007346	biological_process	regulation of mitotic cell cycle
L	0008270	molecular_function	zinc ion binding
L	0008286	biological_process	insulin receptor signaling pathway
L	0010507	biological_process	negative regulation of autophagy
L	0010508	biological_process	positive regulation of autophagy
L	0016567	biological_process	protein ubiquitination
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019221	biological_process	cytokine-mediated signaling pathway
L	0019788	molecular_function	NEDD8 transferase activity
L	0030163	biological_process	protein catabolic process
L	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
L	0030891	cellular_component	VCB complex
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
L	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0031669	biological_process	cellular response to nutrient levels
L	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032480	biological_process	negative regulation of type I interferon production
L	0032481	biological_process	positive regulation of type I interferon production
L	0032869	biological_process	cellular response to insulin stimulus
L	0034198	biological_process	cellular response to amino acid starvation
L	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
L	0034599	biological_process	cellular response to oxidative stress
L	0034644	biological_process	cellular response to UV
L	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
L	0038066	biological_process	p38MAPK cascade
L	0038202	biological_process	TORC1 signaling
L	0042110	biological_process	T cell activation
L	0042770	biological_process	signal transduction in response to DNA damage
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043687	biological_process	post-translational protein modification
L	0044877	molecular_function	protein-containing complex binding
L	0045116	biological_process	protein neddylation
L	0045727	biological_process	positive regulation of translation
L	0045732	biological_process	positive regulation of protein catabolic process
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046627	biological_process	negative regulation of insulin receptor signaling pathway
L	0046872	molecular_function	metal ion binding
L	0060090	molecular_function	molecular adaptor activity
L	0060337	biological_process	type I interferon-mediated signaling pathway
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061663	molecular_function	NEDD8 ligase activity
L	0062197	biological_process	cellular response to chemical stress
L	0070294	biological_process	renal sodium ion absorption
L	0070936	biological_process	protein K48-linked ubiquitination
L	0071230	biological_process	cellular response to amino acid stimulus
L	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090734	cellular_component	site of DNA damage
L	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
L	0097602	molecular_function	cullin family protein binding
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	0160240	biological_process	RNA polymerase II transcription initiation surveillance
L	1900076	biological_process	regulation of cellular response to insulin stimulus
L	1901525	biological_process	negative regulation of mitophagy
L	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
L	1902499	biological_process	positive regulation of protein autoubiquitination
L	1902883	biological_process	negative regulation of response to oxidative stress
L	1904037	biological_process	positive regulation of epithelial cell apoptotic process
L	1904262	biological_process	negative regulation of TORC1 signaling
L	1904263	biological_process	positive regulation of TORC1 signaling
L	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
M	0000082	biological_process	G1/S transition of mitotic cell cycle
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000209	biological_process	protein polyubiquitination
M	0000278	biological_process	mitotic cell cycle
M	0000902	biological_process	cell morphogenesis
M	0000922	cellular_component	spindle pole
M	0001701	biological_process	in utero embryonic development
M	0001822	biological_process	kidney development
M	0001831	biological_process	trophectodermal cellular morphogenesis
M	0004842	molecular_function	ubiquitin-protein transferase activity
M	0005112	molecular_function	Notch binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005794	cellular_component	Golgi apparatus
M	0005813	cellular_component	centrosome
M	0005819	cellular_component	spindle
M	0005827	cellular_component	polar microtubule
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0005929	cellular_component	cilium
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006366	biological_process	transcription by RNA polymerase II
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0006513	biological_process	protein monoubiquitination
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
M	0006915	biological_process	apoptotic process
M	0006950	biological_process	response to stress
M	0006954	biological_process	inflammatory response
M	0006979	biological_process	response to oxidative stress
M	0007080	biological_process	mitotic metaphase chromosome alignment
M	0007165	biological_process	signal transduction
M	0007229	biological_process	integrin-mediated signaling pathway
M	0007369	biological_process	gastrulation
M	0008284	biological_process	positive regulation of cell population proliferation
M	0010467	biological_process	gene expression
M	0010468	biological_process	regulation of gene expression
M	0010558	biological_process	negative regulation of macromolecule biosynthetic process
M	0016020	cellular_component	membrane
M	0016055	biological_process	Wnt signaling pathway
M	0016192	biological_process	vesicle-mediated transport
M	0016477	biological_process	cell migration
M	0016567	biological_process	protein ubiquitination
M	0017145	biological_process	stem cell division
M	0030030	biological_process	cell projection organization
M	0030163	biological_process	protein catabolic process
M	0030332	molecular_function	cyclin binding
M	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
M	0031208	molecular_function	POZ domain binding
M	0031398	biological_process	positive regulation of protein ubiquitination
M	0031461	cellular_component	cullin-RING ubiquitin ligase complex
M	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
M	0031514	cellular_component	motile cilium
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0031648	biological_process	protein destabilization
M	0031669	biological_process	cellular response to nutrient levels
M	0032467	biological_process	positive regulation of cytokinesis
M	0032480	biological_process	negative regulation of type I interferon production
M	0032481	biological_process	positive regulation of type I interferon production
M	0032869	biological_process	cellular response to insulin stimulus
M	0034198	biological_process	cellular response to amino acid starvation
M	0034599	biological_process	cellular response to oxidative stress
M	0035024	biological_process	negative regulation of Rho protein signal transduction
M	0036126	cellular_component	sperm flagellum
M	0040016	biological_process	embryonic cleavage
M	0042802	molecular_function	identical protein binding
M	0042995	cellular_component	cell projection
M	0043149	biological_process	stress fiber assembly
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0044346	biological_process	fibroblast apoptotic process
M	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
M	0048208	biological_process	COPII vesicle coating
M	0051301	biological_process	cell division
M	0051865	biological_process	protein autoubiquitination
M	0060337	biological_process	type I interferon-mediated signaling pathway
M	0061630	molecular_function	ubiquitin protein ligase activity
M	0070062	cellular_component	extracellular exosome
M	0070294	biological_process	renal sodium ion absorption
M	0070936	biological_process	protein K48-linked ubiquitination
M	0071230	biological_process	cellular response to amino acid stimulus
M	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
M	0072576	biological_process	liver morphogenesis
M	0072686	cellular_component	mitotic spindle
M	0080090	biological_process	regulation of primary metabolic process
M	0097193	biological_process	intrinsic apoptotic signaling pathway
M	0098794	cellular_component	postsynapse
M	0098978	cellular_component	glutamatergic synapse
M	0140252	biological_process	regulation protein catabolic process at postsynapse
M	0160072	molecular_function	ubiquitin ligase complex scaffold activity
M	0160240	biological_process	RNA polymerase II transcription initiation surveillance
M	1900076	biological_process	regulation of cellular response to insulin stimulus
M	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
M	1904262	biological_process	negative regulation of TORC1 signaling
M	1904263	biological_process	positive regulation of TORC1 signaling
N	0005737	cellular_component	cytoplasm
N	0006006	biological_process	glucose metabolic process
N	0006629	biological_process	lipid metabolic process
N	0010467	biological_process	gene expression
N	0016567	biological_process	protein ubiquitination
N	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
N	0032868	biological_process	response to insulin
N	0032869	biological_process	cellular response to insulin stimulus
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
N	0070936	biological_process	protein K48-linked ubiquitination
N	1900076	biological_process	regulation of cellular response to insulin stimulus
N	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0000209	biological_process	protein polyubiquitination
O	0000278	biological_process	mitotic cell cycle
O	0000902	biological_process	cell morphogenesis
O	0000922	cellular_component	spindle pole
O	0001701	biological_process	in utero embryonic development
O	0001822	biological_process	kidney development
O	0001831	biological_process	trophectodermal cellular morphogenesis
O	0004842	molecular_function	ubiquitin-protein transferase activity
O	0005112	molecular_function	Notch binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005794	cellular_component	Golgi apparatus
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005827	cellular_component	polar microtubule
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005886	cellular_component	plasma membrane
O	0005929	cellular_component	cilium
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006366	biological_process	transcription by RNA polymerase II
O	0006368	biological_process	transcription elongation by RNA polymerase II
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006513	biological_process	protein monoubiquitination
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
O	0006915	biological_process	apoptotic process
O	0006950	biological_process	response to stress
O	0006954	biological_process	inflammatory response
O	0006979	biological_process	response to oxidative stress
O	0007080	biological_process	mitotic metaphase chromosome alignment
O	0007165	biological_process	signal transduction
O	0007229	biological_process	integrin-mediated signaling pathway
O	0007369	biological_process	gastrulation
O	0008284	biological_process	positive regulation of cell population proliferation
O	0010467	biological_process	gene expression
O	0010468	biological_process	regulation of gene expression
O	0010558	biological_process	negative regulation of macromolecule biosynthetic process
O	0016020	cellular_component	membrane
O	0016055	biological_process	Wnt signaling pathway
O	0016192	biological_process	vesicle-mediated transport
O	0016477	biological_process	cell migration
O	0016567	biological_process	protein ubiquitination
O	0017145	biological_process	stem cell division
O	0030030	biological_process	cell projection organization
O	0030163	biological_process	protein catabolic process
O	0030332	molecular_function	cyclin binding
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0031208	molecular_function	POZ domain binding
O	0031398	biological_process	positive regulation of protein ubiquitination
O	0031461	cellular_component	cullin-RING ubiquitin ligase complex
O	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
O	0031514	cellular_component	motile cilium
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0031648	biological_process	protein destabilization
O	0031669	biological_process	cellular response to nutrient levels
O	0032467	biological_process	positive regulation of cytokinesis
O	0032480	biological_process	negative regulation of type I interferon production
O	0032481	biological_process	positive regulation of type I interferon production
O	0032869	biological_process	cellular response to insulin stimulus
O	0034198	biological_process	cellular response to amino acid starvation
O	0034599	biological_process	cellular response to oxidative stress
O	0035024	biological_process	negative regulation of Rho protein signal transduction
O	0036126	cellular_component	sperm flagellum
O	0040016	biological_process	embryonic cleavage
O	0042802	molecular_function	identical protein binding
O	0042995	cellular_component	cell projection
O	0043149	biological_process	stress fiber assembly
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0044346	biological_process	fibroblast apoptotic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0048208	biological_process	COPII vesicle coating
O	0051301	biological_process	cell division
O	0051865	biological_process	protein autoubiquitination
O	0060337	biological_process	type I interferon-mediated signaling pathway
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0070062	cellular_component	extracellular exosome
O	0070294	biological_process	renal sodium ion absorption
O	0070936	biological_process	protein K48-linked ubiquitination
O	0071230	biological_process	cellular response to amino acid stimulus
O	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
O	0072576	biological_process	liver morphogenesis
O	0072686	cellular_component	mitotic spindle
O	0080090	biological_process	regulation of primary metabolic process
O	0097193	biological_process	intrinsic apoptotic signaling pathway
O	0098794	cellular_component	postsynapse
O	0098978	cellular_component	glutamatergic synapse
O	0140252	biological_process	regulation protein catabolic process at postsynapse
O	0160072	molecular_function	ubiquitin ligase complex scaffold activity
O	0160240	biological_process	RNA polymerase II transcription initiation surveillance
O	1900076	biological_process	regulation of cellular response to insulin stimulus
O	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
O	1904262	biological_process	negative regulation of TORC1 signaling
O	1904263	biological_process	positive regulation of TORC1 signaling
P	0005737	cellular_component	cytoplasm
P	0006006	biological_process	glucose metabolic process
P	0006629	biological_process	lipid metabolic process
P	0010467	biological_process	gene expression
P	0016567	biological_process	protein ubiquitination
P	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
P	0032868	biological_process	response to insulin
P	0032869	biological_process	cellular response to insulin stimulus
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
P	0070936	biological_process	protein K48-linked ubiquitination
P	1900076	biological_process	regulation of cellular response to insulin stimulus
P	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
Q	0000045	biological_process	autophagosome assembly
Q	0000082	biological_process	G1/S transition of mitotic cell cycle
Q	0000165	biological_process	MAPK cascade
Q	0000209	biological_process	protein polyubiquitination
Q	0000423	biological_process	mitophagy
Q	0001837	biological_process	epithelial to mesenchymal transition
Q	0004842	molecular_function	ubiquitin-protein transferase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006281	biological_process	DNA repair
Q	0006283	biological_process	transcription-coupled nucleotide-excision repair
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006513	biological_process	protein monoubiquitination
Q	0006915	biological_process	apoptotic process
Q	0006974	biological_process	DNA damage response
Q	0006979	biological_process	response to oxidative stress
Q	0007040	biological_process	lysosome organization
Q	0007283	biological_process	spermatogenesis
Q	0007346	biological_process	regulation of mitotic cell cycle
Q	0008270	molecular_function	zinc ion binding
Q	0008286	biological_process	insulin receptor signaling pathway
Q	0010507	biological_process	negative regulation of autophagy
Q	0010508	biological_process	positive regulation of autophagy
Q	0016567	biological_process	protein ubiquitination
Q	0016740	molecular_function	transferase activity
Q	0019005	cellular_component	SCF ubiquitin ligase complex
Q	0019221	biological_process	cytokine-mediated signaling pathway
Q	0019788	molecular_function	NEDD8 transferase activity
Q	0030163	biological_process	protein catabolic process
Q	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
Q	0030891	cellular_component	VCB complex
Q	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Q	0031461	cellular_component	cullin-RING ubiquitin ligase complex
Q	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
Q	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
Q	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
Q	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
Q	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
Q	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0031669	biological_process	cellular response to nutrient levels
Q	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Q	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Q	0032480	biological_process	negative regulation of type I interferon production
Q	0032481	biological_process	positive regulation of type I interferon production
Q	0032869	biological_process	cellular response to insulin stimulus
Q	0034198	biological_process	cellular response to amino acid starvation
Q	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
Q	0034599	biological_process	cellular response to oxidative stress
Q	0034644	biological_process	cellular response to UV
Q	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
Q	0038066	biological_process	p38MAPK cascade
Q	0038202	biological_process	TORC1 signaling
Q	0042110	biological_process	T cell activation
Q	0042770	biological_process	signal transduction in response to DNA damage
Q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
Q	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043687	biological_process	post-translational protein modification
Q	0044877	molecular_function	protein-containing complex binding
Q	0045116	biological_process	protein neddylation
Q	0045727	biological_process	positive regulation of translation
Q	0045732	biological_process	positive regulation of protein catabolic process
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046627	biological_process	negative regulation of insulin receptor signaling pathway
Q	0046872	molecular_function	metal ion binding
Q	0060090	molecular_function	molecular adaptor activity
Q	0060337	biological_process	type I interferon-mediated signaling pathway
Q	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
Q	0061630	molecular_function	ubiquitin protein ligase activity
Q	0061663	molecular_function	NEDD8 ligase activity
Q	0062197	biological_process	cellular response to chemical stress
Q	0070294	biological_process	renal sodium ion absorption
Q	0070936	biological_process	protein K48-linked ubiquitination
Q	0071230	biological_process	cellular response to amino acid stimulus
Q	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
Q	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
Q	0090734	cellular_component	site of DNA damage
Q	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
Q	0097602	molecular_function	cullin family protein binding
Q	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Q	0160240	biological_process	RNA polymerase II transcription initiation surveillance
Q	1900076	biological_process	regulation of cellular response to insulin stimulus
Q	1901525	biological_process	negative regulation of mitophagy
Q	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
Q	1902499	biological_process	positive regulation of protein autoubiquitination
Q	1902883	biological_process	negative regulation of response to oxidative stress
Q	1904037	biological_process	positive regulation of epithelial cell apoptotic process
Q	1904262	biological_process	negative regulation of TORC1 signaling
Q	1904263	biological_process	positive regulation of TORC1 signaling
Q	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
R	0000045	biological_process	autophagosome assembly
R	0000082	biological_process	G1/S transition of mitotic cell cycle
R	0000165	biological_process	MAPK cascade
R	0000209	biological_process	protein polyubiquitination
R	0000423	biological_process	mitophagy
R	0001837	biological_process	epithelial to mesenchymal transition
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006283	biological_process	transcription-coupled nucleotide-excision repair
R	0006366	biological_process	transcription by RNA polymerase II
R	0006368	biological_process	transcription elongation by RNA polymerase II
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006513	biological_process	protein monoubiquitination
R	0006915	biological_process	apoptotic process
R	0006974	biological_process	DNA damage response
R	0006979	biological_process	response to oxidative stress
R	0007040	biological_process	lysosome organization
R	0007283	biological_process	spermatogenesis
R	0007346	biological_process	regulation of mitotic cell cycle
R	0008270	molecular_function	zinc ion binding
R	0008286	biological_process	insulin receptor signaling pathway
R	0010507	biological_process	negative regulation of autophagy
R	0010508	biological_process	positive regulation of autophagy
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019005	cellular_component	SCF ubiquitin ligase complex
R	0019221	biological_process	cytokine-mediated signaling pathway
R	0019788	molecular_function	NEDD8 transferase activity
R	0030163	biological_process	protein catabolic process
R	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
R	0030891	cellular_component	VCB complex
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0031669	biological_process	cellular response to nutrient levels
R	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032480	biological_process	negative regulation of type I interferon production
R	0032481	biological_process	positive regulation of type I interferon production
R	0032869	biological_process	cellular response to insulin stimulus
R	0034198	biological_process	cellular response to amino acid starvation
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0034599	biological_process	cellular response to oxidative stress
R	0034644	biological_process	cellular response to UV
R	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
R	0038066	biological_process	p38MAPK cascade
R	0038202	biological_process	TORC1 signaling
R	0042110	biological_process	T cell activation
R	0042770	biological_process	signal transduction in response to DNA damage
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0044877	molecular_function	protein-containing complex binding
R	0045116	biological_process	protein neddylation
R	0045727	biological_process	positive regulation of translation
R	0045732	biological_process	positive regulation of protein catabolic process
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046627	biological_process	negative regulation of insulin receptor signaling pathway
R	0046872	molecular_function	metal ion binding
R	0060090	molecular_function	molecular adaptor activity
R	0060337	biological_process	type I interferon-mediated signaling pathway
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0062197	biological_process	cellular response to chemical stress
R	0070294	biological_process	renal sodium ion absorption
R	0070936	biological_process	protein K48-linked ubiquitination
R	0071230	biological_process	cellular response to amino acid stimulus
R	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
R	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
R	0090734	cellular_component	site of DNA damage
R	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
R	0097602	molecular_function	cullin family protein binding
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	0160240	biological_process	RNA polymerase II transcription initiation surveillance
R	1900076	biological_process	regulation of cellular response to insulin stimulus
R	1901525	biological_process	negative regulation of mitophagy
R	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
R	1902499	biological_process	positive regulation of protein autoubiquitination
R	1902883	biological_process	negative regulation of response to oxidative stress
R	1904037	biological_process	positive regulation of epithelial cell apoptotic process
R	1904262	biological_process	negative regulation of TORC1 signaling
R	1904263	biological_process	positive regulation of TORC1 signaling
R	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA

Chain	Residue	Details
M	ILE741-ALA768

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	270
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
R	CYS53-ASN98
Q	CYS53-ASN98
E	CYS53-ASN98
D	CYS53-ASN98
L	CYS53-ASN98
K	CYS53-ASN98

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:38605244, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O, ECO:0007744|PDB:8Q7H, ECO:0007744|PDB:8RHZ

Chain	Residue	Details
R	CYS42
Q	CYS75
Q	HIS77
Q	HIS80
Q	CYS94
Q	ASP97
E	CYS42
E	CYS45
E	CYS75
E	HIS77
E	HIS80
R	CYS45
E	CYS94
E	ASP97
D	CYS42
D	CYS45
D	CYS75
D	HIS77
D	HIS80
D	CYS94
D	ASP97
L	CYS42
R	CYS75
L	CYS45
L	CYS75
L	HIS77
L	HIS80
L	CYS94
L	ASP97
K	CYS42
K	CYS45
K	CYS75
K	HIS77
R	HIS77
K	HIS80
K	CYS94
K	ASP97
R	HIS80
R	CYS94
R	ASP97
Q	CYS42
Q	CYS45

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:38605244, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O, ECO:0007744|PDB:7Z8B, ECO:0007744|PDB:8Q7H, ECO:0007744|PDB:8RHZ

Chain	Residue	Details
R	CYS53
E	CYS56
E	CYS68
E	HIS82
D	CYS53
D	CYS56
D	CYS68
D	HIS82
L	CYS53
L	CYS56
L	CYS68
R	CYS56
L	HIS82
K	CYS53
K	CYS56
K	CYS68
K	HIS82
R	CYS68
R	HIS82
Q	CYS53
Q	CYS56
Q	CYS68
Q	HIS82
E	CYS53

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0000269|PubMed:38605244, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O, ECO:0007744|PDB:8Q7H, ECO:0007744|PDB:8RHZ

Chain	Residue	Details
R	CYS83
Q	CYS83
E	CYS83
D	CYS83
L	CYS83
K	CYS83

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
R	MET1
Q	MET1
E	MET1
D	MET1
L	MET1
K	MET1

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
R	ALA2
Q	ALA2
E	ALA2
D	ALA2
L	ALA2
K	ALA2

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site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	THR9
Q	THR9
E	THR9
D	THR9
L	THR9
K	THR9

---