8H33

Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006006	biological_process	glucose metabolic process
A	0006629	biological_process	lipid metabolic process
A	0010467	biological_process	gene expression
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0032868	biological_process	response to insulin
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0070936	biological_process	protein K48-linked ubiquitination
A	1900076	biological_process	regulation of cellular response to insulin stimulus
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0000209	biological_process	protein polyubiquitination
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006006	biological_process	glucose metabolic process
B	0006629	biological_process	lipid metabolic process
B	0010467	biological_process	gene expression
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0032868	biological_process	response to insulin
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0070936	biological_process	protein K48-linked ubiquitination
B	1900076	biological_process	regulation of cellular response to insulin stimulus
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000209	biological_process	protein polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0000902	biological_process	cell morphogenesis
C	0000922	cellular_component	spindle pole
C	0001701	biological_process	in utero embryonic development
C	0001822	biological_process	kidney development
C	0001831	biological_process	trophectodermal cellular morphogenesis
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005827	cellular_component	polar microtubule
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0006954	biological_process	inflammatory response
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007165	biological_process	signal transduction
C	0007229	biological_process	integrin-mediated signaling pathway
C	0007369	biological_process	gastrulation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010467	biological_process	gene expression
C	0010468	biological_process	regulation of gene expression
C	0016020	cellular_component	membrane
C	0016055	biological_process	Wnt signaling pathway
C	0016192	biological_process	vesicle-mediated transport
C	0016477	biological_process	cell migration
C	0016567	biological_process	protein ubiquitination
C	0017145	biological_process	stem cell division
C	0030030	biological_process	cell projection organization
C	0030163	biological_process	protein catabolic process
C	0030332	molecular_function	cyclin binding
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0031208	molecular_function	POZ domain binding
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031514	cellular_component	motile cilium
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031648	biological_process	protein destabilization
C	0032467	biological_process	positive regulation of cytokinesis
C	0032480	biological_process	negative regulation of type I interferon production
C	0034599	biological_process	cellular response to oxidative stress
C	0035024	biological_process	negative regulation of Rho protein signal transduction
C	0036126	cellular_component	sperm flagellum
C	0040016	biological_process	embryonic cleavage
C	0042802	molecular_function	identical protein binding
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044346	biological_process	fibroblast apoptotic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0048208	biological_process	COPII vesicle coating
C	0051301	biological_process	cell division
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
C	0072576	biological_process	liver morphogenesis
C	0072686	cellular_component	mitotic spindle
C	0080090	biological_process	regulation of primary metabolic process
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0140252	biological_process	regulation protein catabolic process at postsynapse
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0008270	molecular_function	zinc ion binding
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0042110	biological_process	T cell activation
D	0042770	biological_process	signal transduction in response to DNA damage
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044314	biological_process	protein K27-linked ubiquitination
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0160276	biological_process	negative regulation of beige fat cell differentiation
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901525	biological_process	negative regulation of mitophagy
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0000165	biological_process	MAPK cascade
E	0000209	biological_process	protein polyubiquitination
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006283	biological_process	transcription-coupled nucleotide-excision repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006513	biological_process	protein monoubiquitination
E	0006974	biological_process	DNA damage response
E	0007283	biological_process	spermatogenesis
E	0008270	molecular_function	zinc ion binding
E	0016567	biological_process	protein ubiquitination
E	0016740	molecular_function	transferase activity
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0019788	molecular_function	NEDD8 transferase activity
E	0030163	biological_process	protein catabolic process
E	0030891	cellular_component	VCB complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032480	biological_process	negative regulation of type I interferon production
E	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034644	biological_process	cellular response to UV
E	0042110	biological_process	T cell activation
E	0042770	biological_process	signal transduction in response to DNA damage
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043687	biological_process	post-translational protein modification
E	0044314	biological_process	protein K27-linked ubiquitination
E	0044877	molecular_function	protein-containing complex binding
E	0045116	biological_process	protein neddylation
E	0045732	biological_process	positive regulation of protein catabolic process
E	0046627	biological_process	negative regulation of insulin receptor signaling pathway
E	0046872	molecular_function	metal ion binding
E	0060090	molecular_function	molecular adaptor activity
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0061663	molecular_function	NEDD8 ligase activity
E	0062197	biological_process	cellular response to chemical stress
E	0070936	biological_process	protein K48-linked ubiquitination
E	0071230	biological_process	cellular response to amino acid stimulus
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090734	cellular_component	site of DNA damage
E	0097602	molecular_function	cullin family protein binding
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	0160276	biological_process	negative regulation of beige fat cell differentiation
E	1900076	biological_process	regulation of cellular response to insulin stimulus
E	1901525	biological_process	negative regulation of mitophagy
E	1902499	biological_process	positive regulation of protein autoubiquitination
E	1902883	biological_process	negative regulation of response to oxidative stress
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000209	biological_process	protein polyubiquitination
F	0000278	biological_process	mitotic cell cycle
F	0000902	biological_process	cell morphogenesis
F	0000922	cellular_component	spindle pole
F	0001701	biological_process	in utero embryonic development
F	0001822	biological_process	kidney development
F	0001831	biological_process	trophectodermal cellular morphogenesis
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005112	molecular_function	Notch binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005827	cellular_component	polar microtubule
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006513	biological_process	protein monoubiquitination
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006915	biological_process	apoptotic process
F	0006950	biological_process	response to stress
F	0006954	biological_process	inflammatory response
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0007165	biological_process	signal transduction
F	0007229	biological_process	integrin-mediated signaling pathway
F	0007369	biological_process	gastrulation
F	0008284	biological_process	positive regulation of cell population proliferation
F	0010467	biological_process	gene expression
F	0010468	biological_process	regulation of gene expression
F	0016020	cellular_component	membrane
F	0016055	biological_process	Wnt signaling pathway
F	0016192	biological_process	vesicle-mediated transport
F	0016477	biological_process	cell migration
F	0016567	biological_process	protein ubiquitination
F	0017145	biological_process	stem cell division
F	0030030	biological_process	cell projection organization
F	0030163	biological_process	protein catabolic process
F	0030332	molecular_function	cyclin binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0031208	molecular_function	POZ domain binding
F	0031398	biological_process	positive regulation of protein ubiquitination
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
F	0031514	cellular_component	motile cilium
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031648	biological_process	protein destabilization
F	0032467	biological_process	positive regulation of cytokinesis
F	0032480	biological_process	negative regulation of type I interferon production
F	0034599	biological_process	cellular response to oxidative stress
F	0035024	biological_process	negative regulation of Rho protein signal transduction
F	0036126	cellular_component	sperm flagellum
F	0040016	biological_process	embryonic cleavage
F	0042802	molecular_function	identical protein binding
F	0043149	biological_process	stress fiber assembly
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0044346	biological_process	fibroblast apoptotic process
F	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
F	0048208	biological_process	COPII vesicle coating
F	0051301	biological_process	cell division
F	0051865	biological_process	protein autoubiquitination
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0070062	cellular_component	extracellular exosome
F	0070936	biological_process	protein K48-linked ubiquitination
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
F	0072576	biological_process	liver morphogenesis
F	0072686	cellular_component	mitotic spindle
F	0080090	biological_process	regulation of primary metabolic process
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0140252	biological_process	regulation protein catabolic process at postsynapse
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	1900076	biological_process	regulation of cellular response to insulin stimulus
F	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0000209	biological_process	protein polyubiquitination
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006006	biological_process	glucose metabolic process
G	0006629	biological_process	lipid metabolic process
G	0010467	biological_process	gene expression
G	0016567	biological_process	protein ubiquitination
G	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
G	0032868	biological_process	response to insulin
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0070936	biological_process	protein K48-linked ubiquitination
G	1900076	biological_process	regulation of cellular response to insulin stimulus
G	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
H	0000082	biological_process	G1/S transition of mitotic cell cycle
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000209	biological_process	protein polyubiquitination
H	0000278	biological_process	mitotic cell cycle
H	0000902	biological_process	cell morphogenesis
H	0000922	cellular_component	spindle pole
H	0001701	biological_process	in utero embryonic development
H	0001822	biological_process	kidney development
H	0001831	biological_process	trophectodermal cellular morphogenesis
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005112	molecular_function	Notch binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005827	cellular_component	polar microtubule
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
H	0006915	biological_process	apoptotic process
H	0006950	biological_process	response to stress
H	0006954	biological_process	inflammatory response
H	0007080	biological_process	mitotic metaphase chromosome alignment
H	0007165	biological_process	signal transduction
H	0007229	biological_process	integrin-mediated signaling pathway
H	0007369	biological_process	gastrulation
H	0008284	biological_process	positive regulation of cell population proliferation
H	0010467	biological_process	gene expression
H	0010468	biological_process	regulation of gene expression
H	0016020	cellular_component	membrane
H	0016055	biological_process	Wnt signaling pathway
H	0016192	biological_process	vesicle-mediated transport
H	0016477	biological_process	cell migration
H	0016567	biological_process	protein ubiquitination
H	0017145	biological_process	stem cell division
H	0030030	biological_process	cell projection organization
H	0030163	biological_process	protein catabolic process
H	0030332	molecular_function	cyclin binding
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0031208	molecular_function	POZ domain binding
H	0031398	biological_process	positive regulation of protein ubiquitination
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031514	cellular_component	motile cilium
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0031648	biological_process	protein destabilization
H	0032467	biological_process	positive regulation of cytokinesis
H	0032480	biological_process	negative regulation of type I interferon production
H	0034599	biological_process	cellular response to oxidative stress
H	0035024	biological_process	negative regulation of Rho protein signal transduction
H	0036126	cellular_component	sperm flagellum
H	0040016	biological_process	embryonic cleavage
H	0042802	molecular_function	identical protein binding
H	0043149	biological_process	stress fiber assembly
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0044346	biological_process	fibroblast apoptotic process
H	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
H	0048208	biological_process	COPII vesicle coating
H	0051301	biological_process	cell division
H	0051865	biological_process	protein autoubiquitination
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070062	cellular_component	extracellular exosome
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
H	0072576	biological_process	liver morphogenesis
H	0072686	cellular_component	mitotic spindle
H	0080090	biological_process	regulation of primary metabolic process
H	0097193	biological_process	intrinsic apoptotic signaling pathway
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0140252	biological_process	regulation protein catabolic process at postsynapse
H	0160072	molecular_function	ubiquitin ligase complex scaffold activity
H	1900076	biological_process	regulation of cellular response to insulin stimulus
H	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
H	1904263	biological_process	positive regulation of TORC1 signaling
I	0000082	biological_process	G1/S transition of mitotic cell cycle
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000209	biological_process	protein polyubiquitination
I	0000278	biological_process	mitotic cell cycle
I	0000902	biological_process	cell morphogenesis
I	0000922	cellular_component	spindle pole
I	0001701	biological_process	in utero embryonic development
I	0001822	biological_process	kidney development
I	0001831	biological_process	trophectodermal cellular morphogenesis
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005112	molecular_function	Notch binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005794	cellular_component	Golgi apparatus
I	0005813	cellular_component	centrosome
I	0005819	cellular_component	spindle
I	0005827	cellular_component	polar microtubule
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006513	biological_process	protein monoubiquitination
I	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
I	0006915	biological_process	apoptotic process
I	0006950	biological_process	response to stress
I	0006954	biological_process	inflammatory response
I	0007080	biological_process	mitotic metaphase chromosome alignment
I	0007165	biological_process	signal transduction
I	0007229	biological_process	integrin-mediated signaling pathway
I	0007369	biological_process	gastrulation
I	0008284	biological_process	positive regulation of cell population proliferation
I	0010467	biological_process	gene expression
I	0010468	biological_process	regulation of gene expression
I	0016020	cellular_component	membrane
I	0016055	biological_process	Wnt signaling pathway
I	0016192	biological_process	vesicle-mediated transport
I	0016477	biological_process	cell migration
I	0016567	biological_process	protein ubiquitination
I	0017145	biological_process	stem cell division
I	0030030	biological_process	cell projection organization
I	0030163	biological_process	protein catabolic process
I	0030332	molecular_function	cyclin binding
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0031208	molecular_function	POZ domain binding
I	0031398	biological_process	positive regulation of protein ubiquitination
I	0031461	cellular_component	cullin-RING ubiquitin ligase complex
I	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
I	0031514	cellular_component	motile cilium
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0031648	biological_process	protein destabilization
I	0032467	biological_process	positive regulation of cytokinesis
I	0032480	biological_process	negative regulation of type I interferon production
I	0034599	biological_process	cellular response to oxidative stress
I	0035024	biological_process	negative regulation of Rho protein signal transduction
I	0036126	cellular_component	sperm flagellum
I	0040016	biological_process	embryonic cleavage
I	0042802	molecular_function	identical protein binding
I	0043149	biological_process	stress fiber assembly
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0044346	biological_process	fibroblast apoptotic process
I	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
I	0048208	biological_process	COPII vesicle coating
I	0051301	biological_process	cell division
I	0051865	biological_process	protein autoubiquitination
I	0061630	molecular_function	ubiquitin protein ligase activity
I	0070062	cellular_component	extracellular exosome
I	0070936	biological_process	protein K48-linked ubiquitination
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
I	0072576	biological_process	liver morphogenesis
I	0072686	cellular_component	mitotic spindle
I	0080090	biological_process	regulation of primary metabolic process
I	0097193	biological_process	intrinsic apoptotic signaling pathway
I	0098794	cellular_component	postsynapse
I	0098978	cellular_component	glutamatergic synapse
I	0140252	biological_process	regulation protein catabolic process at postsynapse
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity
I	1900076	biological_process	regulation of cellular response to insulin stimulus
I	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
I	1904263	biological_process	positive regulation of TORC1 signaling
J	0000209	biological_process	protein polyubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006006	biological_process	glucose metabolic process
J	0006629	biological_process	lipid metabolic process
J	0010467	biological_process	gene expression
J	0016567	biological_process	protein ubiquitination
J	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
J	0032868	biological_process	response to insulin
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
J	0070936	biological_process	protein K48-linked ubiquitination
J	1900076	biological_process	regulation of cellular response to insulin stimulus
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	0000165	biological_process	MAPK cascade
K	0000209	biological_process	protein polyubiquitination
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006283	biological_process	transcription-coupled nucleotide-excision repair
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006513	biological_process	protein monoubiquitination
K	0006974	biological_process	DNA damage response
K	0007283	biological_process	spermatogenesis
K	0008270	molecular_function	zinc ion binding
K	0016567	biological_process	protein ubiquitination
K	0016740	molecular_function	transferase activity
K	0019005	cellular_component	SCF ubiquitin ligase complex
K	0019788	molecular_function	NEDD8 transferase activity
K	0030163	biological_process	protein catabolic process
K	0030891	cellular_component	VCB complex
K	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
K	0031461	cellular_component	cullin-RING ubiquitin ligase complex
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
K	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
K	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
K	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0032480	biological_process	negative regulation of type I interferon production
K	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
K	0034599	biological_process	cellular response to oxidative stress
K	0034644	biological_process	cellular response to UV
K	0042110	biological_process	T cell activation
K	0042770	biological_process	signal transduction in response to DNA damage
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043687	biological_process	post-translational protein modification
K	0044314	biological_process	protein K27-linked ubiquitination
K	0044877	molecular_function	protein-containing complex binding
K	0045116	biological_process	protein neddylation
K	0045732	biological_process	positive regulation of protein catabolic process
K	0046627	biological_process	negative regulation of insulin receptor signaling pathway
K	0046872	molecular_function	metal ion binding
K	0060090	molecular_function	molecular adaptor activity
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0061663	molecular_function	NEDD8 ligase activity
K	0062197	biological_process	cellular response to chemical stress
K	0070936	biological_process	protein K48-linked ubiquitination
K	0071230	biological_process	cellular response to amino acid stimulus
K	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0090734	cellular_component	site of DNA damage
K	0097602	molecular_function	cullin family protein binding
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	0160240	biological_process	RNA polymerase II transcription initiation surveillance
K	0160276	biological_process	negative regulation of beige fat cell differentiation
K	1900076	biological_process	regulation of cellular response to insulin stimulus
K	1901525	biological_process	negative regulation of mitophagy
K	1902499	biological_process	positive regulation of protein autoubiquitination
K	1902883	biological_process	negative regulation of response to oxidative stress
K	1904263	biological_process	positive regulation of TORC1 signaling
L	0000165	biological_process	MAPK cascade
L	0000209	biological_process	protein polyubiquitination
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006283	biological_process	transcription-coupled nucleotide-excision repair
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006974	biological_process	DNA damage response
L	0007283	biological_process	spermatogenesis
L	0008270	molecular_function	zinc ion binding
L	0016567	biological_process	protein ubiquitination
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019788	molecular_function	NEDD8 transferase activity
L	0030163	biological_process	protein catabolic process
L	0030891	cellular_component	VCB complex
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
L	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032480	biological_process	negative regulation of type I interferon production
L	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
L	0034599	biological_process	cellular response to oxidative stress
L	0034644	biological_process	cellular response to UV
L	0042110	biological_process	T cell activation
L	0042770	biological_process	signal transduction in response to DNA damage
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043687	biological_process	post-translational protein modification
L	0044314	biological_process	protein K27-linked ubiquitination
L	0044877	molecular_function	protein-containing complex binding
L	0045116	biological_process	protein neddylation
L	0045732	biological_process	positive regulation of protein catabolic process
L	0046627	biological_process	negative regulation of insulin receptor signaling pathway
L	0046872	molecular_function	metal ion binding
L	0060090	molecular_function	molecular adaptor activity
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061663	molecular_function	NEDD8 ligase activity
L	0062197	biological_process	cellular response to chemical stress
L	0070936	biological_process	protein K48-linked ubiquitination
L	0071230	biological_process	cellular response to amino acid stimulus
L	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090734	cellular_component	site of DNA damage
L	0097602	molecular_function	cullin family protein binding
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	0160240	biological_process	RNA polymerase II transcription initiation surveillance
L	0160276	biological_process	negative regulation of beige fat cell differentiation
L	1900076	biological_process	regulation of cellular response to insulin stimulus
L	1901525	biological_process	negative regulation of mitophagy
L	1902499	biological_process	positive regulation of protein autoubiquitination
L	1902883	biological_process	negative regulation of response to oxidative stress
L	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA

Chain	Residue	Details
F	ILE741-ALA768

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	384
Details	Domain: {"description":"BACK","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	144
Details	Repeat: {"description":"Kelch 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	152
Details	Repeat: {"description":"Kelch 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	184
Details	Repeat: {"description":"Kelch 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	180
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	248
Details	Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	84
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	64
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"UniProtKB","id":"Q13616","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---