8GYW
Cryo-EM structure of human CEPT1 complexed with CDP-choline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004142 | molecular_function | diacylglycerol cholinephosphotransferase activity |
| A | 0004307 | molecular_function | ethanolaminephosphotransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0006657 | biological_process | CDP-choline pathway |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047359 | molecular_function | 1-alkenyl-2-acylglycerol choline phosphotransferase activity |
| B | 0004142 | molecular_function | diacylglycerol cholinephosphotransferase activity |
| B | 0004307 | molecular_function | ethanolaminephosphotransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| B | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| B | 0006657 | biological_process | CDP-choline pathway |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047359 | molecular_function | 1-alkenyl-2-acylglycerol choline phosphotransferase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00379 |
| Number of Residues | 23 |
| Details | CDP_ALCOHOL_P_TRANSF CDP-alcohol phosphatidyltransferases signature. DGkqARrtnsssplGelfDhgcD |
| Chain | Residue | Details |
| B | ASP136-ASP158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 378 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"37137909","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GYW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GYX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"37137909","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37137909","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37137909","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GYW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GYX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Increases basicity of active site His","evidences":[{"source":"UniProtKB","id":"Q4KLV1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
