8GX3

The crystal structure of human Calpain-1 protease core in complex with 14c

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001533	cellular_component	cornified envelope
A	0004198	molecular_function	calcium-dependent cysteine-type endopeptidase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016241	biological_process	regulation of macroautophagy
A	0016787	molecular_function	hydrolase activity
A	0032801	biological_process	receptor catabolic process
A	0046872	molecular_function	metal ion binding
A	0050790	biological_process	regulation of catalytic activity
A	0060056	biological_process	mammary gland involution
A	0070062	cellular_component	extracellular exosome
A	0097264	biological_process	self proteolysis
A	0098989	biological_process	NMDA selective glutamate receptor signaling pathway
A	0110158	cellular_component	calpain complex
A	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRDGNGKLGlvEF

Chain	Residue	Details
A	ASP598-PHE610
A	ASP628-MET640

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site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA

Chain	Residue	Details
A	GLN109-ALA120

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	299
Details	Domain: {"description":"Calpain catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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