8GRF

Crystal structure of F-box protein in the ternary complex with adaptor protein Skp1(DL) and its substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004108	molecular_function	obsolete citrate (Si)-synthase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005975	biological_process	carbohydrate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0006101	biological_process	citrate metabolic process
A	0016740	molecular_function	transferase activity
A	0036440	molecular_function	citrate synthase activity
A	0042802	molecular_function	identical protein binding
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0004108	molecular_function	obsolete citrate (Si)-synthase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005975	biological_process	carbohydrate metabolic process
B	0006099	biological_process	tricarboxylic acid cycle
B	0006101	biological_process	citrate metabolic process
B	0016740	molecular_function	transferase activity
B	0036440	molecular_function	citrate synthase activity
B	0042802	molecular_function	identical protein binding
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000278	biological_process	mitotic cell cycle
D	0000409	biological_process	regulation of transcription by galactose
D	0000776	cellular_component	kinetochore
D	0000781	cellular_component	chromosome, telomeric region
D	0000921	biological_process	septin ring assembly
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0007035	biological_process	vacuolar acidification
D	0007096	biological_process	regulation of exit from mitosis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008053	biological_process	mitochondrial fusion
D	0010458	biological_process	exit from mitosis
D	0010828	biological_process	positive regulation of D-glucose transmembrane transport
D	0012505	cellular_component	endomembrane system
D	0016567	biological_process	protein ubiquitination
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0030466	biological_process	silent mating-type cassette heterochromatin formation
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031335	biological_process	obsolete regulation of sulfur amino acid metabolic process
D	0031509	biological_process	subtelomeric heterochromatin formation
D	0031518	cellular_component	CBF3 complex
D	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
D	0043254	biological_process	regulation of protein-containing complex assembly
D	0043291	cellular_component	RAVE complex
D	0045116	biological_process	protein neddylation
D	0051382	biological_process	kinetochore assembly
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0065003	biological_process	protein-containing complex assembly
D	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
D	0071406	biological_process	cellular response to methylmercury
D	0097602	molecular_function	cullin family protein binding
D	2000766	biological_process	negative regulation of cytoplasmic translation

Functional Information from PROSITE/UniProt

site_id	PS00480
Number of Residues	13
Details	CITRATE_SYNTHASE Citrate synthase signature. GYGHaVl.RktDPR

Chain	Residue	Details
A	GLY336-ARG348

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"C-terminal peroxisome targeting signal (PTS1)","evidences":[{"source":"PubMed","id":"2181273","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10117","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12872131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	37
Details	Domain: {"description":"F-box"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	59
Details	Region: {"description":"Interaction with the F-box domain of F-box proteins","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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