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8GRE

F-box protein in complex with skp1(FL) and substrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004108molecular_functioncitrate (Si)-synthase activity
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005777cellular_componentperoxisome
A0005975biological_processcarbohydrate metabolic process
A0006099biological_processtricarboxylic acid cycle
A0006101biological_processcitrate metabolic process
A0016740molecular_functiontransferase activity
A0036440molecular_functioncitrate synthase activity
A0042802molecular_functionidentical protein binding
A0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
B0004108molecular_functioncitrate (Si)-synthase activity
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005777cellular_componentperoxisome
B0005975biological_processcarbohydrate metabolic process
B0006099biological_processtricarboxylic acid cycle
B0006101biological_processcitrate metabolic process
B0016740molecular_functiontransferase activity
B0036440molecular_functioncitrate synthase activity
B0042802molecular_functionidentical protein binding
B0046912molecular_functionacyltransferase activity, acyl groups converted into alkyl on transfer
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0016567biological_processprotein ubiquitination
C0019005cellular_componentSCF ubiquitin ligase complex
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0000082biological_processG1/S transition of mitotic cell cycle
D0000086biological_processG2/M transition of mitotic cell cycle
D0000278biological_processmitotic cell cycle
D0000409biological_processregulation of transcription by galactose
D0000775cellular_componentchromosome, centromeric region
D0000776cellular_componentkinetochore
D0000781cellular_componentchromosome, telomeric region
D0000921biological_processseptin ring assembly
D0003677molecular_functionDNA binding
D0003688molecular_functionDNA replication origin binding
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0006511biological_processubiquitin-dependent protein catabolic process
D0007035biological_processvacuolar acidification
D0007096biological_processregulation of exit from mitosis
D0007346biological_processregulation of mitotic cell cycle
D0008053biological_processmitochondrial fusion
D0010458biological_processexit from mitosis
D0010828biological_processpositive regulation of glucose transmembrane transport
D0012505cellular_componentendomembrane system
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019222biological_processregulation of metabolic process
D0030466biological_processsilent mating-type cassette heterochromatin formation
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031335biological_processregulation of sulfur amino acid metabolic process
D0031509biological_processsubtelomeric heterochromatin formation
D0031518cellular_componentCBF3 complex
D0031573biological_processmitotic intra-S DNA damage checkpoint signaling
D0043254biological_processregulation of protein-containing complex assembly
D0043291cellular_componentRAVE complex
D0045116biological_processprotein neddylation
D0051382biological_processkinetochore assembly
D0061630molecular_functionubiquitin protein ligase activity
D0065003biological_processprotein-containing complex assembly
D0070072biological_processvacuolar proton-transporting V-type ATPase complex assembly
D0071406biological_processcellular response to methylmercury
D0097602molecular_functioncullin family protein binding
D2000766biological_processnegative regulation of cytoplasmic translation
Functional Information from PROSITE/UniProt
site_idPS00480
Number of Residues13
DetailsCITRATE_SYNTHASE Citrate synthase signature. GYGHaVl.RktDPR
ChainResidueDetails
AGLY336-ARG348

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
DTHR177
AHIS339
AASP394
BHIS293
BHIS339
BASP394

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ASER21
BSER21

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ALYS218
ALYS239
BLYS218
BLYS239

site_idSWS_FT_FI4
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12872131
ChainResidueDetails
ALYS354
ALYS385
BLYS354
BLYS385

219869

PDB entries from 2024-05-15

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