8GOA

Crystal Structure of Glycerol Dehydrogenase in the absence of NAD+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006071	biological_process	glycerol metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008888	molecular_function	glycerol dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019147	molecular_function	(R)-aminopropanol dehydrogenase activity
A	0019588	biological_process	anaerobic glycerol catabolic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0051596	biological_process	methylglyoxal catabolic process
B	0005829	cellular_component	cytosol
B	0006071	biological_process	glycerol metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008888	molecular_function	glycerol dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019147	molecular_function	(R)-aminopropanol dehydrogenase activity
B	0019588	biological_process	anaerobic glycerol catabolic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0051596	biological_process	methylglyoxal catabolic process
C	0005829	cellular_component	cytosol
C	0006071	biological_process	glycerol metabolic process
C	0008270	molecular_function	zinc ion binding
C	0008888	molecular_function	glycerol dehydrogenase (NAD+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019147	molecular_function	(R)-aminopropanol dehydrogenase activity
C	0019588	biological_process	anaerobic glycerol catabolic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051289	biological_process	protein homotetramerization
C	0051596	biological_process	methylglyoxal catabolic process
D	0005829	cellular_component	cytosol
D	0006071	biological_process	glycerol metabolic process
D	0008270	molecular_function	zinc ion binding
D	0008888	molecular_function	glycerol dehydrogenase (NAD+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019147	molecular_function	(R)-aminopropanol dehydrogenase activity
D	0019588	biological_process	anaerobic glycerol catabolic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051289	biological_process	protein homotetramerization
D	0051596	biological_process	methylglyoxal catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00060
Number of Residues	21
Details	ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. SgVGfeSGgLAAahaVhNGlT

Chain	Residue	Details
A	SER241-THR261

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site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. FESGGLAA

Chain	Residue	Details
A	PHE245-ALA252

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site_id	PS00913
Number of Residues	29
Details	ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. VIvDtkivagaParllAaGigDALatwfE

Chain	Residue	Details
A	VAL150-GLU178

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P32816

Chain	Residue	Details
A	ASP37
B	GLY94
B	LYS95
B	THR116
B	SER119
B	SER125
B	LEU127
B	TYR131
C	ASP37
C	GLY94
C	LYS95
A	GLY94
C	THR116
C	SER119
C	SER125
C	LEU127
C	TYR131
D	ASP37
D	GLY94
D	LYS95
D	THR116
D	SER119
A	LYS95
D	SER125
D	LEU127
D	TYR131
A	THR116
A	SER119
A	SER125
A	LEU127
A	TYR131
B	ASP37

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site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:30839292, ECO:0007744|PDB:5ZXL

Chain	Residue	Details
A	ASP121
C	ASP171
C	HIS254
C	HIS271
D	ASP121
D	ASP171
D	HIS254
D	HIS271
A	ASP171
A	HIS254
A	HIS271
B	ASP121
B	ASP171
B	HIS254
B	HIS271
C	ASP121

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