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8FL0

Human nucleolar pre-60S ribosomal subunit (State H)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BA0002181biological_processcytoplasmic translation
BA0003723molecular_functionRNA binding
BA0003735molecular_functionstructural constituent of ribosome
BA0005515molecular_functionprotein binding
BA0005634cellular_componentnucleus
BA0005730cellular_componentnucleolus
BA0005737cellular_componentcytoplasm
BA0005829cellular_componentcytosol
BA0005840cellular_componentribosome
BA0005925cellular_componentfocal adhesion
BA0006412biological_processtranslation
BA0014069cellular_componentpostsynaptic density
BA0016020cellular_componentmembrane
BA0022625cellular_componentcytosolic large ribosomal subunit
BA0022626cellular_componentcytosolic ribosome
BA0045202cellular_componentsynapse
BA0070062cellular_componentextracellular exosome
BA0070180molecular_functionlarge ribosomal subunit rRNA binding
BA1990904cellular_componentribonucleoprotein complex
L50000027biological_processribosomal large subunit assembly
L50002181biological_processcytoplasmic translation
L50003723molecular_functionRNA binding
L50003735molecular_functionstructural constituent of ribosome
L50005515molecular_functionprotein binding
L50005634cellular_componentnucleus
L50005654cellular_componentnucleoplasm
L50005730cellular_componentnucleolus
L50005737cellular_componentcytoplasm
L50005829cellular_componentcytosol
L50005840cellular_componentribosome
L50006364biological_processrRNA processing
L50006412biological_processtranslation
L50006605biological_processprotein targeting
L50008097molecular_function5S rRNA binding
L50010628biological_processpositive regulation of gene expression
L50016020cellular_componentmembrane
L50019843molecular_functionrRNA binding
L50022625cellular_componentcytosolic large ribosomal subunit
L50022626cellular_componentcytosolic ribosome
L50031625molecular_functionubiquitin protein ligase binding
L50032092biological_processpositive regulation of protein binding
L50032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
L50032991cellular_componentprotein-containing complex
L50034504biological_processprotein localization to nucleus
L50042273biological_processribosomal large subunit biogenesis
L50050821biological_processprotein stabilization
L50070062cellular_componentextracellular exosome
L51901796biological_processregulation of signal transduction by p53 class mediator
L51901798biological_processpositive regulation of signal transduction by p53 class mediator
L51904667biological_processnegative regulation of ubiquitin protein ligase activity
L51990904cellular_componentribonucleoprotein complex
L51990948molecular_functionubiquitin ligase inhibitor activity
L52000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
L52000435biological_processnegative regulation of protein neddylation
L70002181biological_processcytoplasmic translation
L70003723molecular_functionRNA binding
L70003729molecular_functionmRNA binding
L70003735molecular_functionstructural constituent of ribosome
L70005634cellular_componentnucleus
L70005730cellular_componentnucleolus
L70005737cellular_componentcytoplasm
L70005829cellular_componentcytosol
L70005840cellular_componentribosome
L70005925cellular_componentfocal adhesion
L70006412biological_processtranslation
L70006417biological_processregulation of translation
L70015934cellular_componentlarge ribosomal subunit
L70016020cellular_componentmembrane
L70017148biological_processnegative regulation of translation
L70022625cellular_componentcytosolic large ribosomal subunit
L70022626cellular_componentcytosolic ribosome
L70032496biological_processresponse to lipopolysaccharide
L70042592biological_processhomeostatic process
L70045202cellular_componentsynapse
L70048246biological_processmacrophage chemotaxis
L70060425biological_processlung morphogenesis
L70071346biological_processcellular response to type II interferon
L70097452cellular_componentGAIT complex
L71901194biological_processnegative regulation of formation of translation preinitiation complex
L71990904cellular_componentribonucleoprotein complex
L80002181biological_processcytoplasmic translation
L80003723molecular_functionRNA binding
L80003735molecular_functionstructural constituent of ribosome
L80005515molecular_functionprotein binding
L80005737cellular_componentcytoplasm
L80005829cellular_componentcytosol
L80005840cellular_componentribosome
L80006364biological_processrRNA processing
L80006412biological_processtranslation
L80014069cellular_componentpostsynaptic density
L80016020cellular_componentmembrane
L80022625cellular_componentcytosolic large ribosomal subunit
L80022626cellular_componentcytosolic ribosome
L80042273biological_processribosomal large subunit biogenesis
L80045202cellular_componentsynapse
L80045296molecular_functioncadherin binding
L80070062cellular_componentextracellular exosome
L81990904cellular_componentribonucleoprotein complex
LB0002181biological_processcytoplasmic translation
LB0003723molecular_functionRNA binding
LB0003735molecular_functionstructural constituent of ribosome
LB0005515molecular_functionprotein binding
LB0005634cellular_componentnucleus
LB0005730cellular_componentnucleolus
LB0005737cellular_componentcytoplasm
LB0005783cellular_componentendoplasmic reticulum
LB0005791cellular_componentrough endoplasmic reticulum
LB0005829cellular_componentcytosol
LB0005840cellular_componentribosome
LB0005925cellular_componentfocal adhesion
LB0006412biological_processtranslation
LB0016020cellular_componentmembrane
LB0022625cellular_componentcytosolic large ribosomal subunit
LB0022626cellular_componentcytosolic ribosome
LB0043232cellular_componentintracellular non-membrane-bounded organelle
LB1990904cellular_componentribonucleoprotein complex
LC0002181biological_processcytoplasmic translation
LC0003723molecular_functionRNA binding
LC0003735molecular_functionstructural constituent of ribosome
LC0005515molecular_functionprotein binding
LC0005737cellular_componentcytoplasm
LC0005829cellular_componentcytosol
LC0005840cellular_componentribosome
LC0006412biological_processtranslation
LC0016020cellular_componentmembrane
LC0022625cellular_componentcytosolic large ribosomal subunit
LC0022626cellular_componentcytosolic ribosome
LC1990904cellular_componentribonucleoprotein complex
LE0002181biological_processcytoplasmic translation
LE0003723molecular_functionRNA binding
LE0003735molecular_functionstructural constituent of ribosome
LE0005515molecular_functionprotein binding
LE0005737cellular_componentcytoplasm
LE0005783cellular_componentendoplasmic reticulum
LE0005829cellular_componentcytosol
LE0005840cellular_componentribosome
LE0006412biological_processtranslation
LE0016020cellular_componentmembrane
LE0022625cellular_componentcytosolic large ribosomal subunit
LE0022626cellular_componentcytosolic ribosome
LE0045202cellular_componentsynapse
LE1990904cellular_componentribonucleoprotein complex
LG0000122biological_processnegative regulation of transcription by RNA polymerase II
LG0001223molecular_functiontranscription coactivator binding
LG0002181biological_processcytoplasmic translation
LG0003723molecular_functionRNA binding
LG0003735molecular_functionstructural constituent of ribosome
LG0005515molecular_functionprotein binding
LG0005654cellular_componentnucleoplasm
LG0005730cellular_componentnucleolus
LG0005737cellular_componentcytoplasm
LG0005829cellular_componentcytosol
LG0005840cellular_componentribosome
LG0005925cellular_componentfocal adhesion
LG0006412biological_processtranslation
LG0006610biological_processribosomal protein import into nucleus
LG0008284biological_processpositive regulation of cell population proliferation
LG0010628biological_processpositive regulation of gene expression
LG0016020cellular_componentmembrane
LG0022625cellular_componentcytosolic large ribosomal subunit
LG0022626cellular_componentcytosolic ribosome
LG0031625molecular_functionubiquitin protein ligase binding
LG0032986biological_processprotein-DNA complex disassembly
LG0032991cellular_componentprotein-containing complex
LG0045202cellular_componentsynapse
LG0050821biological_processprotein stabilization
LG0070062cellular_componentextracellular exosome
LG0070180molecular_functionlarge ribosomal subunit rRNA binding
LG0070314biological_processG1 to G0 transition
LG0072717biological_processcellular response to actinomycin D
LG1901798biological_processpositive regulation of signal transduction by p53 class mediator
LG1903450biological_processregulation of G1 to G0 transition
LG1904667biological_processnegative regulation of ubiquitin protein ligase activity
LG1990904cellular_componentribonucleoprotein complex
LG1990948molecular_functionubiquitin ligase inhibitor activity
LG2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
LL0002181biological_processcytoplasmic translation
LL0003723molecular_functionRNA binding
LL0003735molecular_functionstructural constituent of ribosome
LL0005515molecular_functionprotein binding
LL0005737cellular_componentcytoplasm
LL0005829cellular_componentcytosol
LL0005840cellular_componentribosome
LL0006412biological_processtranslation
LL0016020cellular_componentmembrane
LL0022625cellular_componentcytosolic large ribosomal subunit
LL0022626cellular_componentcytosolic ribosome
LL0030425cellular_componentdendrite
LL0036464cellular_componentcytoplasmic ribonucleoprotein granule
LL0044297cellular_componentcell body
LL0045202cellular_componentsynapse
LL0070062cellular_componentextracellular exosome
LL1990904cellular_componentribonucleoprotein complex
LN0002181biological_processcytoplasmic translation
LN0003723molecular_functionRNA binding
LN0003735molecular_functionstructural constituent of ribosome
LN0005515molecular_functionprotein binding
LN0005634cellular_componentnucleus
LN0005730cellular_componentnucleolus
LN0005737cellular_componentcytoplasm
LN0005829cellular_componentcytosol
LN0005840cellular_componentribosome
LN0005925cellular_componentfocal adhesion
LN0006412biological_processtranslation
LN0022625cellular_componentcytosolic large ribosomal subunit
LN0022626cellular_componentcytosolic ribosome
LN0032991cellular_componentprotein-containing complex
LN0070062cellular_componentextracellular exosome
LN0071353biological_processcellular response to interleukin-4
LN1990904cellular_componentribonucleoprotein complex
LQ0002181biological_processcytoplasmic translation
LQ0003723molecular_functionRNA binding
LQ0003735molecular_functionstructural constituent of ribosome
LQ0005737cellular_componentcytoplasm
LQ0005829cellular_componentcytosol
LQ0005840cellular_componentribosome
LQ0006412biological_processtranslation
LQ0016020cellular_componentmembrane
LQ0022625cellular_componentcytosolic large ribosomal subunit
LQ0022626cellular_componentcytosolic ribosome
LQ1990904cellular_componentribonucleoprotein complex
LT0000049molecular_functiontRNA binding
LT0002181biological_processcytoplasmic translation
LT0003723molecular_functionRNA binding
LT0003735molecular_functionstructural constituent of ribosome
LT0005515molecular_functionprotein binding
LT0005737cellular_componentcytoplasm
LT0005829cellular_componentcytosol
LT0005840cellular_componentribosome
LT0006364biological_processrRNA processing
LT0006412biological_processtranslation
LT0016020cellular_componentmembrane
LT0022625cellular_componentcytosolic large ribosomal subunit
LT0022626cellular_componentcytosolic ribosome
LT0042273biological_processribosomal large subunit biogenesis
LT0070062cellular_componentextracellular exosome
LT1990904cellular_componentribonucleoprotein complex
NB0003723molecular_functionRNA binding
NB0005515molecular_functionprotein binding
NB0005525molecular_functionGTP binding
NB0005615cellular_componentextracellular space
NB0005634cellular_componentnucleus
NB0005654cellular_componentnucleoplasm
NB0005694cellular_componentchromosome
NB0005730cellular_componentnucleolus
NB0016020cellular_componentmembrane
NB0016604cellular_componentnuclear body
NB0017145biological_processstem cell division
NB0019827biological_processstem cell population maintenance
NB0030496cellular_componentmidbody
NB0032206biological_processpositive regulation of telomere maintenance
NB0033235biological_processpositive regulation of protein sumoylation
NB0042127biological_processregulation of cell population proliferation
NB0048027molecular_functionmRNA 5'-UTR binding
NB1902895biological_processpositive regulation of miRNA transcription
NB1904816biological_processpositive regulation of protein localization to chromosome, telomeric region
NC0003723molecular_functionRNA binding
NC0003924molecular_functionGTPase activity
NC0005525molecular_functionGTP binding
NC0005634cellular_componentnucleus
NC0005730cellular_componentnucleolus
NC0008150biological_processbiological_process
NC0016020cellular_componentmembrane
NC0042254biological_processribosome biogenesis
ND0000027biological_processribosomal large subunit assembly
ND0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND0000470biological_processmaturation of LSU-rRNA
ND0003723molecular_functionRNA binding
ND0005515molecular_functionprotein binding
ND0005634cellular_componentnucleus
ND0005654cellular_componentnucleoplasm
ND0005694cellular_componentchromosome
ND0005730cellular_componentnucleolus
ND0006364biological_processrRNA processing
ND0008097molecular_function5S rRNA binding
ND0019843molecular_functionrRNA binding
ND0042254biological_processribosome biogenesis
ND0042273biological_processribosomal large subunit biogenesis
ND1901796biological_processregulation of signal transduction by p53 class mediator
ND1902570biological_processprotein localization to nucleolus
NF0000460biological_processmaturation of 5.8S rRNA
NF0000470biological_processmaturation of LSU-rRNA
NF0003723molecular_functionRNA binding
NF0005634cellular_componentnucleus
NF0005730cellular_componentnucleolus
NF0006364biological_processrRNA processing
NF0030687cellular_componentpreribosome, large subunit precursor
NF0042254biological_processribosome biogenesis
NF1990904cellular_componentribonucleoprotein complex
NJ0000027biological_processribosomal large subunit assembly
NJ0000278biological_processmitotic cell cycle
NJ0001756biological_processsomitogenesis
NJ0001822biological_processkidney development
NJ0001826biological_processinner cell mass cell differentiation
NJ0005515molecular_functionprotein binding
NJ0005634cellular_componentnucleus
NJ0005654cellular_componentnucleoplasm
NJ0005730cellular_componentnucleolus
NJ0007219biological_processNotch signaling pathway
NJ0042273biological_processribosomal large subunit biogenesis
NJ0045930biological_processnegative regulation of mitotic cell cycle
NJ0048705biological_processskeletal system morphogenesis
NJ0061484biological_processhematopoietic stem cell homeostasis
NJ0090263biological_processpositive regulation of canonical Wnt signaling pathway
NK0001099molecular_functionbasal RNA polymerase II transcription machinery binding
NK0003723molecular_functionRNA binding
NK0005515molecular_functionprotein binding
NK0005634cellular_componentnucleus
NK0005694cellular_componentchromosome
NK0005730cellular_componentnucleolus
NK0060999biological_processpositive regulation of dendritic spine development
NK0097484biological_processdendrite extension
NZ0003723molecular_functionRNA binding
NZ0005515molecular_functionprotein binding
NZ0005634cellular_componentnucleus
NZ0005654cellular_componentnucleoplasm
NZ0005694cellular_componentchromosome
NZ0005730cellular_componentnucleolus
SA0002181biological_processcytoplasmic translation
SA0003723molecular_functionRNA binding
SA0003735molecular_functionstructural constituent of ribosome
SA0005515molecular_functionprotein binding
SA0005634cellular_componentnucleus
SA0005730cellular_componentnucleolus
SA0005737cellular_componentcytoplasm
SA0005791cellular_componentrough endoplasmic reticulum
SA0005829cellular_componentcytosol
SA0005840cellular_componentribosome
SA0005925cellular_componentfocal adhesion
SA0006412biological_processtranslation
SA0016020cellular_componentmembrane
SA0022625cellular_componentcytosolic large ribosomal subunit
SA0022626cellular_componentcytosolic ribosome
SA0070062cellular_componentextracellular exosome
SA1990904cellular_componentribonucleoprotein complex
SB0000027biological_processribosomal large subunit assembly
SB0002181biological_processcytoplasmic translation
SB0003723molecular_functionRNA binding
SB0003730molecular_functionmRNA 3'-UTR binding
SB0003735molecular_functionstructural constituent of ribosome
SB0005515molecular_functionprotein binding
SB0005634cellular_componentnucleus
SB0005654cellular_componentnucleoplasm
SB0005730cellular_componentnucleolus
SB0005737cellular_componentcytoplasm
SB0005783cellular_componentendoplasmic reticulum
SB0005829cellular_componentcytosol
SB0005840cellular_componentribosome
SB0005925cellular_componentfocal adhesion
SB0006364biological_processrRNA processing
SB0006412biological_processtranslation
SB0008097molecular_function5S rRNA binding
SB0010628biological_processpositive regulation of gene expression
SB0016020cellular_componentmembrane
SB0019843molecular_functionrRNA binding
SB0022625cellular_componentcytosolic large ribosomal subunit
SB0022626cellular_componentcytosolic ribosome
SB0031625molecular_functionubiquitin protein ligase binding
SB0032991cellular_componentprotein-containing complex
SB0042273biological_processribosomal large subunit biogenesis
SB0045727biological_processpositive regulation of translation
SB0048027molecular_functionmRNA 5'-UTR binding
SB0050821biological_processprotein stabilization
SB0070062cellular_componentextracellular exosome
SB1901796biological_processregulation of signal transduction by p53 class mediator
SB1904667biological_processnegative regulation of ubiquitin protein ligase activity
SB1990904cellular_componentribonucleoprotein complex
SB1990948molecular_functionubiquitin ligase inhibitor activity
SB2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
SB2000435biological_processnegative regulation of protein neddylation
SC0000027biological_processribosomal large subunit assembly
SC0002181biological_processcytoplasmic translation
SC0003677molecular_functionDNA binding
SC0003723molecular_functionRNA binding
SC0003735molecular_functionstructural constituent of ribosome
SC0005515molecular_functionprotein binding
SC0005634cellular_componentnucleus
SC0005737cellular_componentcytoplasm
SC0005783cellular_componentendoplasmic reticulum
SC0005791cellular_componentrough endoplasmic reticulum
SC0005829cellular_componentcytosol
SC0005840cellular_componentribosome
SC0005925cellular_componentfocal adhesion
SC0006355biological_processregulation of DNA-templated transcription
SC0006412biological_processtranslation
SC0014069cellular_componentpostsynaptic density
SC0016020cellular_componentmembrane
SC0022625cellular_componentcytosolic large ribosomal subunit
SC0022626cellular_componentcytosolic ribosome
SC0036464cellular_componentcytoplasmic ribonucleoprotein granule
SC0045202cellular_componentsynapse
SC0045296molecular_functioncadherin binding
SC1990904cellular_componentribonucleoprotein complex
SD0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SD0002181biological_processcytoplasmic translation
SD0003677molecular_functionDNA binding
SD0003723molecular_functionRNA binding
SD0003729molecular_functionmRNA binding
SD0003735molecular_functionstructural constituent of ribosome
SD0005515molecular_functionprotein binding
SD0005634cellular_componentnucleus
SD0005730cellular_componentnucleolus
SD0005737cellular_componentcytoplasm
SD0005829cellular_componentcytosol
SD0005840cellular_componentribosome
SD0005925cellular_componentfocal adhesion
SD0006364biological_processrRNA processing
SD0006412biological_processtranslation
SD0014069cellular_componentpostsynaptic density
SD0016020cellular_componentmembrane
SD0022625cellular_componentcytosolic large ribosomal subunit
SD0022626cellular_componentcytosolic ribosome
SD0042273biological_processribosomal large subunit biogenesis
SD0042802molecular_functionidentical protein binding
SD1990904cellular_componentribonucleoprotein complex
SG0002181biological_processcytoplasmic translation
SG0003723molecular_functionRNA binding
SG0003735molecular_functionstructural constituent of ribosome
SG0005515molecular_functionprotein binding
SG0005634cellular_componentnucleus
SG0005737cellular_componentcytoplasm
SG0005829cellular_componentcytosol
SG0005840cellular_componentribosome
SG0005925cellular_componentfocal adhesion
SG0006412biological_processtranslation
SG0016020cellular_componentmembrane
SG0019843molecular_functionrRNA binding
SG0022625cellular_componentcytosolic large ribosomal subunit
SG0022626cellular_componentcytosolic ribosome
SG1990904cellular_componentribonucleoprotein complex
SK0000054biological_processribosomal subunit export from nucleus
SK0000460biological_processmaturation of 5.8S rRNA
SK0000470biological_processmaturation of LSU-rRNA
SK0003743molecular_functiontranslation initiation factor activity
SK0005515molecular_functionprotein binding
SK0005634cellular_componentnucleus
SK0005638cellular_componentlamin filament
SK0005654cellular_componentnucleoplasm
SK0005730cellular_componentnucleolus
SK0005737cellular_componentcytoplasm
SK0005829cellular_componentcytosol
SK0005882cellular_componentintermediate filament
SK0006110biological_processregulation of glycolytic process
SK0006412biological_processtranslation
SK0006413biological_processtranslational initiation
SK0030687cellular_componentpreribosome, large subunit precursor
SK0032868biological_processresponse to insulin
SK0035195biological_processmiRNA-mediated post-transcriptional gene silencing
SK0035278biological_processmiRNA-mediated gene silencing by inhibition of translation
SK0042254biological_processribosome biogenesis
SK0042256biological_processcytosolic ribosome assembly
SK0042273biological_processribosomal large subunit biogenesis
SK0042304biological_processregulation of fatty acid biosynthetic process
SK0043022molecular_functionribosome binding
SK0043023molecular_functionribosomal large subunit binding
SK0045202cellular_componentsynapse
SK0045652biological_processregulation of megakaryocyte differentiation
SK0045727biological_processpositive regulation of translation
SK0070062cellular_componentextracellular exosome
SK1902626biological_processassembly of large subunit precursor of preribosome
SK2000377biological_processregulation of reactive oxygen species metabolic process
SQ0000027biological_processribosomal large subunit assembly
SQ0000956biological_processnuclear-transcribed mRNA catabolic process
SQ0003723molecular_functionRNA binding
SQ0005515molecular_functionprotein binding
SQ0005634cellular_componentnucleus
SQ0005730cellular_componentnucleolus
SQ0005737cellular_componentcytoplasm
SQ0006364biological_processrRNA processing
SQ0030687cellular_componentpreribosome, large subunit precursor
SQ0042254biological_processribosome biogenesis
SQ0042273biological_processribosomal large subunit biogenesis
SR0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
SR0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SR0001649biological_processosteoblast differentiation
SR0003723molecular_functionRNA binding
SR0003924molecular_functionGTPase activity
SR0005515molecular_functionprotein binding
SR0005525molecular_functionGTP binding
SR0005634cellular_componentnucleus
SR0005654cellular_componentnucleoplasm
SR0005730cellular_componentnucleolus
SR0005737cellular_componentcytoplasm
SR0005829cellular_componentcytosol
SR0008156biological_processnegative regulation of DNA replication
SR0008285biological_processnegative regulation of cell population proliferation
SR0016020cellular_componentmembrane
SR0022408biological_processnegative regulation of cell-cell adhesion
SR0030336biological_processnegative regulation of cell migration
SR0031397biological_processnegative regulation of protein ubiquitination
SR0031965cellular_componentnuclear membrane
SR0033342biological_processnegative regulation of collagen binding
SR0042254biological_processribosome biogenesis
SR0042273biological_processribosomal large subunit biogenesis
SR0048471cellular_componentperinuclear region of cytoplasm
SR0050821biological_processprotein stabilization
SR1990275molecular_functionpreribosome binding
ST0000027biological_processribosomal large subunit assembly
ST0000447biological_processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ST0000794cellular_componentcondensed nuclear chromosome
ST0002244biological_processhematopoietic progenitor cell differentiation
ST0003723molecular_functionRNA binding
ST0005515molecular_functionprotein binding
ST0005634cellular_componentnucleus
ST0005654cellular_componentnucleoplasm
ST0005730cellular_componentnucleolus
ST0005783cellular_componentendoplasmic reticulum
ST0007080biological_processmitotic metaphase chromosome alignment
ST0008097molecular_function5S rRNA binding
ST0030687cellular_componentpreribosome, large subunit precursor
ST0042254biological_processribosome biogenesis
ST0042273biological_processribosomal large subunit biogenesis
ST1901796biological_processregulation of signal transduction by p53 class mediator
ST1902570biological_processprotein localization to nucleolus
SV0003735molecular_functionstructural constituent of ribosome
SV0005515molecular_functionprotein binding
SV0005634cellular_componentnucleus
SV0005654cellular_componentnucleoplasm
SV0005730cellular_componentnucleolus
SV0005840cellular_componentribosome
SV0006412biological_processtranslation
SV0042254biological_processribosome biogenesis
SV0042273biological_processribosomal large subunit biogenesis
Functional Information from PROSITE/UniProt
site_idPS00049
Number of Residues27
DetailsRIBOSOMAL_L14 Ribosomal protein L14 signature. AVVIrqrksyrrk.DGvflyFedNagVI
ChainResidueDetails
LGALA79-ILE105

site_idPS00358
Number of Residues17
DetailsRIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLTGQtpVfSkARyT
ChainResidueDetails
L5LEU40-THR56

site_idPS00359
Number of Residues16
DetailsRIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG
ChainResidueDetails
BALYS130-GLY145

site_idPS00474
Number of Residues24
DetailsRIBOSOMAL_L3 Ribosomal protein L3 signature. FgqdemiDviGvTkGKGykGvtsR
ChainResidueDetails
LNPHE211-ARG234

site_idPS00580
Number of Residues21
DetailsRIBOSOMAL_L32E Ribosomal protein L32e signature. FiRhqsdRyvKIkrn..WRKprG
ChainResidueDetails
LQPHE20-GLY40

site_idPS00634
Number of Residues33
DetailsRIBOSOMAL_L30 Ribosomal protein L30 signature. VLqlLrLrQifNgTfvklnkasinMLriVepYI
ChainResidueDetails
SDVAL108-ILE140

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASGsgDtTVRFWDL
ChainResidueDetails
NJLEU129-LEU143
NJVAL219-THR233
NJVAL387-GLY401
NJLEU429-VAL443

site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV
ChainResidueDetails
SAGLY15-VAL22

site_idPS00700
Number of Residues22
DetailsRIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QattVknKdiRkFlDGIYVseK
ChainResidueDetails
SGGLN163-LYS184

site_idPS00783
Number of Residues24
DetailsRIBOSOMAL_L13 Ribosomal protein L13 signature. VRGMLPhktkrGQaaldrLkVFdG
ChainResidueDetails
L7VAL84-GLY107

site_idPS00939
Number of Residues27
DetailsRIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaASAlpalvmsKGH
ChainResidueDetails
SAASN116-HIS142

site_idPS01073
Number of Residues18
DetailsRIBOSOMAL_L24E Ribosomal protein L24e signature. FcSgpIyPGhGmmFvRnD
ChainResidueDetails
SVPHE8-ASP25

site_idPS01105
Number of Residues22
DetailsRIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKVtRaHGnsGmVrAkFrsnLP
ChainResidueDetails
LTGLY72-PRO93

site_idPS01106
Number of Residues18
DetailsRIBOSOMAL_L18E Ribosomal protein L18e signature. KrLfmSRtnRPpLSLsRM
ChainResidueDetails
LBLYS49-MET66

site_idPS01170
Number of Residues19
DetailsRIBOSOMAL_L6E Ribosomal protein L6e signature. NrvPLRRthqkFVIATSt.K
ChainResidueDetails
SCASN182-LYS200

site_idPS01171
Number of Residues26
DetailsRIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikgmgtvqk.GmpHkcYhGkTG
ChainResidueDetails
LEGLY37-GLY62

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
LCTYR63
SRASP221
SRASN289

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
LCSER71
L7ARG140
SALYS333

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62717
ChainResidueDetails
LCLYS76
NZSER66
LBLYS164

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62717
ChainResidueDetails
LCSER123
SKSER175
STLYS226
STLYS266

site_idSWS_FT_FI5
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447
ChainResidueDetails
LCLYS11
SRSER470
BALYS83

site_idSWS_FT_FI6
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
L5LYS38
LCLYS128
LCLYS170

site_idSWS_FT_FI7
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
L5LYS52
LNLYS224
NBLYS179
NBLYS196
NBLYS253
NBLYS267
NBLYS275

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
SRSER558
LNLYS399

site_idSWS_FT_FI9
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
SRLYS103
LNLYS366

site_idSWS_FT_FI10
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
SASER365
SRLYS332
SRLYS534

site_idSWS_FT_FI11
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
SALYS239
SALYS327

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0007744|PubMed:25114211
ChainResidueDetails
NZSER113
SALYS364

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
NZSER128

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJ89
ChainResidueDetails
NZSER188
NZSER218

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
NZSER217

site_idSWS_FT_FI16
Number of Residues1
DetailsMOD_RES: Citrulline => ECO:0000250
ChainResidueDetails
NZARG342

222415

PDB entries from 2024-07-10

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