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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8FFZ

TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene

Functional Information from GO Data
ChainGOidnamespacecontents
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001010molecular_functionRNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0008270molecular_functionzinc ion binding
A0042791biological_process5S class rRNA transcription by RNA polymerase III
A0046872molecular_functionmetal ion binding
B0000127cellular_componenttranscription factor TFIIIC complex
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0006351biological_processDNA-templated transcription
B0006383biological_processtranscription by RNA polymerase III
B0006384biological_processtranscription initiation at RNA polymerase III promoter
B0008301molecular_functionDNA binding, bending
B0042791biological_process5S class rRNA transcription by RNA polymerase III
B0071168biological_processprotein localization to chromatin
C0000127cellular_componenttranscription factor TFIIIC complex
C0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
C0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0006351biological_processDNA-templated transcription
C0006383biological_processtranscription by RNA polymerase III
C0006384biological_processtranscription initiation at RNA polymerase III promoter
C0008301molecular_functionDNA binding, bending
C0042791biological_process5S class rRNA transcription by RNA polymerase III
D0000127cellular_componenttranscription factor TFIIIC complex
D0000995molecular_functionRNA polymerase III general transcription initiation factor activity
D0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
D0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
D0003677molecular_functionDNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0006351biological_processDNA-templated transcription
D0006383biological_processtranscription by RNA polymerase III
D0006384biological_processtranscription initiation at RNA polymerase III promoter
D0008301molecular_functionDNA binding, bending
D0042791biological_process5S class rRNA transcription by RNA polymerase III
E0000127cellular_componenttranscription factor TFIIIC complex
E0000995molecular_functionRNA polymerase III general transcription initiation factor activity
E0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
E0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
E0003677molecular_functionDNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0006351biological_processDNA-templated transcription
E0006383biological_processtranscription by RNA polymerase III
E0006384biological_processtranscription initiation at RNA polymerase III promoter
E0042791biological_process5S class rRNA transcription by RNA polymerase III
F0000127cellular_componenttranscription factor TFIIIC complex
F0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
F0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
F0003677molecular_functionDNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0006351biological_processDNA-templated transcription
F0006383biological_processtranscription by RNA polymerase III
F0006384biological_processtranscription initiation at RNA polymerase III promoter
F0008270molecular_functionzinc ion binding
F0008301molecular_functionDNA binding, bending
F0042791biological_process5S class rRNA transcription by RNA polymerase III
G0000127cellular_componenttranscription factor TFIIIC complex
G0000995molecular_functionRNA polymerase III general transcription initiation factor activity
G0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
G0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
G0003677molecular_functionDNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0006351biological_processDNA-templated transcription
G0006383biological_processtranscription by RNA polymerase III
G0006384biological_processtranscription initiation at RNA polymerase III promoter
G0008301molecular_functionDNA binding, bending
G0016791molecular_functionphosphatase activity
G0042791biological_process5S class rRNA transcription by RNA polymerase III
H0003677molecular_functionDNA binding
H0006352biological_processDNA-templated transcription initiation
H0017025molecular_functionTBP-class protein binding
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues24
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CdydgCdkaFtrpsilteHqlsv.H
ChainResidueDetails
ACYS51-HIS74
ACYS82-HIS102
ACYS110-HIS130
ACYS136-HIS159
ACYS165-HIS186
ACYS196-HIS219
ACYS224-HIS244
ACYS367-HIS389
site_idPS00351
Number of Residues50
DetailsTFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePKttaLIFaSGKMvvtGAKseddsklAsrkyariI
ChainResidueDetails
HTYR420-ILE469
HTYR511-LEU560
site_idPS00782
Number of Residues16
DetailsTFIIB Transcription factor TFIIB repeat signature. GRrsqNVIASCLYVAC
ChainResidueDetails
HGLY119-CYS134
HGLY217-CYS232
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsZinc finger: {"description":"C2H2-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues22
DetailsZinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues22
DetailsZinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues25
DetailsZinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues23
DetailsZinc finger: {"description":"C2H2-type 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues25
DetailsZinc finger: {"description":"C2H2-type 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues22
DetailsZinc finger: {"description":"C2H2-type 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues24
DetailsZinc finger: {"description":"C2H2-type 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues24
DetailsZinc finger: {"description":"C2H2-type 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues33
DetailsRepeat: {"description":"TPR 1"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues33
DetailsRepeat: {"description":"TPR 2"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues33
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues33
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues33
DetailsRepeat: {"description":"TPR 5"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues33
DetailsRepeat: {"description":"TPR 6"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues34
DetailsRepeat: {"description":"TPR 7"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues33
DetailsRepeat: {"description":"TPR 8"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues33
DetailsRepeat: {"description":"TPR 9"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues33
DetailsRepeat: {"description":"TPR 10"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues33
DetailsRepeat: {"description":"TPR 11"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues94
DetailsRepeat: {"description":"1"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues513
DetailsRegion: {"description":"Sufficient for interaction with TFC8","evidences":[{"source":"PubMed","id":"16115780","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsSite: {"description":"Involved in the interaction with TFC6"}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues156
DetailsRepeat: {"description":"2"}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248636

PDB entries from 2026-02-04

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