8FFZ
TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0000981 | molecular_function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| A | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| B | 0000127 | cellular_component | transcription factor TFIIIC complex |
| B | 0000995 | molecular_function | RNA polymerase III general transcription initiation factor activity |
| B | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| B | 0001003 | molecular_function | RNA polymerase III type 2 promoter sequence-specific DNA binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006383 | biological_process | transcription by RNA polymerase III |
| B | 0006384 | biological_process | transcription initiation at RNA polymerase III promoter |
| B | 0008301 | molecular_function | DNA binding, bending |
| B | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| B | 0071168 | biological_process | protein localization to chromatin |
| C | 0000127 | cellular_component | transcription factor TFIIIC complex |
| C | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| C | 0001003 | molecular_function | RNA polymerase III type 2 promoter sequence-specific DNA binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006383 | biological_process | transcription by RNA polymerase III |
| C | 0006384 | biological_process | transcription initiation at RNA polymerase III promoter |
| C | 0008301 | molecular_function | DNA binding, bending |
| C | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| D | 0000127 | cellular_component | transcription factor TFIIIC complex |
| D | 0000995 | molecular_function | RNA polymerase III general transcription initiation factor activity |
| D | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| D | 0001003 | molecular_function | RNA polymerase III type 2 promoter sequence-specific DNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0006383 | biological_process | transcription by RNA polymerase III |
| D | 0006384 | biological_process | transcription initiation at RNA polymerase III promoter |
| D | 0008301 | molecular_function | DNA binding, bending |
| D | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| E | 0000127 | cellular_component | transcription factor TFIIIC complex |
| E | 0000995 | molecular_function | RNA polymerase III general transcription initiation factor activity |
| E | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| E | 0001003 | molecular_function | RNA polymerase III type 2 promoter sequence-specific DNA binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0006383 | biological_process | transcription by RNA polymerase III |
| E | 0006384 | biological_process | transcription initiation at RNA polymerase III promoter |
| E | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| F | 0000127 | cellular_component | transcription factor TFIIIC complex |
| F | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| F | 0001003 | molecular_function | RNA polymerase III type 2 promoter sequence-specific DNA binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0006383 | biological_process | transcription by RNA polymerase III |
| F | 0006384 | biological_process | transcription initiation at RNA polymerase III promoter |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0008301 | molecular_function | DNA binding, bending |
| F | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| G | 0000127 | cellular_component | transcription factor TFIIIC complex |
| G | 0000995 | molecular_function | RNA polymerase III general transcription initiation factor activity |
| G | 0001002 | molecular_function | RNA polymerase III type 1 promoter sequence-specific DNA binding |
| G | 0001003 | molecular_function | RNA polymerase III type 2 promoter sequence-specific DNA binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0006383 | biological_process | transcription by RNA polymerase III |
| G | 0006384 | biological_process | transcription initiation at RNA polymerase III promoter |
| G | 0008301 | molecular_function | DNA binding, bending |
| G | 0016791 | molecular_function | phosphatase activity |
| G | 0042791 | biological_process | 5S class rRNA transcription by RNA polymerase III |
| H | 0003677 | molecular_function | DNA binding |
| H | 0006352 | biological_process | DNA-templated transcription initiation |
| H | 0017025 | molecular_function | TBP-class protein binding |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 24 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CdydgCdkaFtrpsilteHqlsv.H |
| Chain | Residue | Details |
| A | CYS51-HIS74 | |
| A | CYS82-HIS102 | |
| A | CYS110-HIS130 | |
| A | CYS136-HIS159 | |
| A | CYS165-HIS186 | |
| A | CYS196-HIS219 | |
| A | CYS224-HIS244 | |
| A | CYS367-HIS389 |
| site_id | PS00351 |
| Number of Residues | 50 |
| Details | TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePKttaLIFaSGKMvvtGAKseddsklAsrkyariI |
| Chain | Residue | Details |
| H | TYR420-ILE469 | |
| H | TYR511-LEU560 |
| site_id | PS00782 |
| Number of Residues | 16 |
| Details | TFIIB Transcription factor TFIIB repeat signature. GRrsqNVIASCLYVAC |
| Chain | Residue | Details |
| H | GLY119-CYS134 | |
| H | GLY217-CYS232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Zinc finger: {"description":"C2H2-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | Zinc finger: {"description":"C2H2-type 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 25 |
| Details | Zinc finger: {"description":"C2H2-type 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Zinc finger: {"description":"C2H2-type 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Zinc finger: {"description":"C2H2-type 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | Zinc finger: {"description":"C2H2-type 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"TPR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 94 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 513 |
| Details | Region: {"description":"Sufficient for interaction with TFC8","evidences":[{"source":"PubMed","id":"16115780","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in the interaction with TFC6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 156 |
| Details | Repeat: {"description":"2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |






