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8FDT

Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005524molecular_functionATP binding
A0007018biological_processmicrotubule-based movement
A0008569molecular_functionminus-end-directed microtubule motor activity
A0016887molecular_functionATP hydrolysis activity
A0030286cellular_componentdynein complex
A0045505molecular_functiondynein intermediate chain binding
A0051959molecular_functiondynein light intermediate chain binding
B0000132biological_processestablishment of mitotic spindle orientation
B0000226biological_processmicrotubule cytoskeleton organization
B0000235cellular_componentastral microtubule
B0000776cellular_componentkinetochore
B0001667biological_processameboidal-type cell migration
B0001675biological_processacrosome assembly
B0001764biological_processneuron migration
B0001961biological_processpositive regulation of cytokine-mediated signaling pathway
B0003824molecular_functioncatalytic activity
B0003908molecular_functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005871cellular_componentkinesin complex
B0005874cellular_componentmicrotubule
B0005875cellular_componentmicrotubule associated complex
B0005881cellular_componentcytoplasmic microtubule
B0005938cellular_componentcell cortex
B0006281biological_processDNA repair
B0007017biological_processmicrotubule-based process
B0007097biological_processnuclear migration
B0007254biological_processJNK cascade
B0007268biological_processchemical synaptic transmission
B0007281biological_processgerm cell development
B0007399biological_processnervous system development
B0007405biological_processneuroblast proliferation
B0007611biological_processlearning or memory
B0008017molecular_functionmicrotubule binding
B0008090biological_processretrograde axonal transport
B0008201molecular_functionheparin binding
B0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
B0008344biological_processadult locomotory behavior
B0009306biological_processprotein secretion
B0010977biological_processnegative regulation of neuron projection development
B0015630cellular_componentmicrotubule cytoskeleton
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016477biological_processcell migration
B0017145biological_processstem cell division
B0019226biological_processtransmission of nerve impulse
B0021540biological_processcorpus callosum morphogenesis
B0021766biological_processhippocampus development
B0021819biological_processlayer formation in cerebral cortex
B0021895biological_processcerebral cortex neuron differentiation
B0021987biological_processcerebral cortex development
B0030036biological_processactin cytoskeleton organization
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0031023biological_processmicrotubule organizing center organization
B0031252cellular_componentcell leading edge
B0031514cellular_componentmotile cilium
B0031965cellular_componentnuclear membrane
B0031982cellular_componentvesicle
B0032420cellular_componentstereocilium
B0034452molecular_functiondynactin binding
B0036035biological_processosteoclast development
B0038026biological_processreelin-mediated signaling pathway
B0040019biological_processpositive regulation of embryonic development
B0042249biological_processestablishment of planar polarity of embryonic epithelium
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043274molecular_functionphospholipase binding
B0043622biological_processcortical microtubule organization
B0044877molecular_functionprotein-containing complex binding
B0045505molecular_functiondynein intermediate chain binding
B0045773biological_processpositive regulation of axon extension
B0045931biological_processpositive regulation of mitotic cell cycle
B0046329biological_processnegative regulation of JNK cascade
B0046469biological_processplatelet activating factor metabolic process
B0046982molecular_functionprotein heterodimerization activity
B0047496biological_processvesicle transport along microtubule
B0048471cellular_componentperinuclear region of cytoplasm
B0048854biological_processbrain morphogenesis
B0050804biological_processmodulation of chemical synaptic transmission
B0050885biological_processneuromuscular process controlling balance
B0051010molecular_functionmicrotubule plus-end binding
B0051012biological_processmicrotubule sliding
B0051081biological_processnuclear membrane disassembly
B0051130biological_processpositive regulation of cellular component organization
B0051219molecular_functionphosphoprotein binding
B0051301biological_processcell division
B0051649biological_processestablishment of localization in cell
B0051660biological_processestablishment of centrosome localization
B0051661biological_processmaintenance of centrosome location
B0060117biological_processauditory receptor cell development
B0061003biological_processpositive regulation of dendritic spine morphogenesis
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070840molecular_functiondynein complex binding
B0090102biological_processcochlea development
B0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
B0090724cellular_componentcentral region of growth cone
B0097529biological_processmyeloid leukocyte migration
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0099175biological_processregulation of postsynapse organization
B0140650biological_processradial glia-guided pyramidal neuron migration
B1904115cellular_componentaxon cytoplasm
B1904936biological_processinterneuron migration
C0000132biological_processestablishment of mitotic spindle orientation
C0000226biological_processmicrotubule cytoskeleton organization
C0000235cellular_componentastral microtubule
C0000776cellular_componentkinetochore
C0001667biological_processameboidal-type cell migration
C0001675biological_processacrosome assembly
C0001764biological_processneuron migration
C0001961biological_processpositive regulation of cytokine-mediated signaling pathway
C0003824molecular_functioncatalytic activity
C0003908molecular_functionmethylated-DNA-[protein]-cysteine S-methyltransferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005871cellular_componentkinesin complex
C0005874cellular_componentmicrotubule
C0005875cellular_componentmicrotubule associated complex
C0005881cellular_componentcytoplasmic microtubule
C0005938cellular_componentcell cortex
C0006281biological_processDNA repair
C0007017biological_processmicrotubule-based process
C0007097biological_processnuclear migration
C0007254biological_processJNK cascade
C0007268biological_processchemical synaptic transmission
C0007281biological_processgerm cell development
C0007399biological_processnervous system development
C0007405biological_processneuroblast proliferation
C0007611biological_processlearning or memory
C0008017molecular_functionmicrotubule binding
C0008090biological_processretrograde axonal transport
C0008201molecular_functionheparin binding
C0008247cellular_component1-alkyl-2-acetylglycerophosphocholine esterase complex
C0008344biological_processadult locomotory behavior
C0009306biological_processprotein secretion
C0010977biological_processnegative regulation of neuron projection development
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016042biological_processlipid catabolic process
C0016477biological_processcell migration
C0017145biological_processstem cell division
C0019226biological_processtransmission of nerve impulse
C0021540biological_processcorpus callosum morphogenesis
C0021766biological_processhippocampus development
C0021819biological_processlayer formation in cerebral cortex
C0021895biological_processcerebral cortex neuron differentiation
C0021987biological_processcerebral cortex development
C0030036biological_processactin cytoskeleton organization
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0031023biological_processmicrotubule organizing center organization
C0031252cellular_componentcell leading edge
C0031514cellular_componentmotile cilium
C0031965cellular_componentnuclear membrane
C0031982cellular_componentvesicle
C0032420cellular_componentstereocilium
C0034452molecular_functiondynactin binding
C0036035biological_processosteoclast development
C0038026biological_processreelin-mediated signaling pathway
C0040019biological_processpositive regulation of embryonic development
C0042249biological_processestablishment of planar polarity of embryonic epithelium
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043274molecular_functionphospholipase binding
C0043622biological_processcortical microtubule organization
C0044877molecular_functionprotein-containing complex binding
C0045505molecular_functiondynein intermediate chain binding
C0045773biological_processpositive regulation of axon extension
C0045931biological_processpositive regulation of mitotic cell cycle
C0046329biological_processnegative regulation of JNK cascade
C0046469biological_processplatelet activating factor metabolic process
C0046982molecular_functionprotein heterodimerization activity
C0047496biological_processvesicle transport along microtubule
C0048471cellular_componentperinuclear region of cytoplasm
C0048854biological_processbrain morphogenesis
C0050804biological_processmodulation of chemical synaptic transmission
C0050885biological_processneuromuscular process controlling balance
C0051010molecular_functionmicrotubule plus-end binding
C0051012biological_processmicrotubule sliding
C0051081biological_processnuclear membrane disassembly
C0051130biological_processpositive regulation of cellular component organization
C0051219molecular_functionphosphoprotein binding
C0051301biological_processcell division
C0051649biological_processestablishment of localization in cell
C0051660biological_processestablishment of centrosome localization
C0051661biological_processmaintenance of centrosome location
C0060117biological_processauditory receptor cell development
C0061003biological_processpositive regulation of dendritic spine morphogenesis
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0070840molecular_functiondynein complex binding
C0090102biological_processcochlea development
C0090176biological_processmicrotubule cytoskeleton organization involved in establishment of planar polarity
C0090724cellular_componentcentral region of growth cone
C0097529biological_processmyeloid leukocyte migration
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099175biological_processregulation of postsynapse organization
C0140650biological_processradial glia-guided pyramidal neuron migration
C1904115cellular_componentaxon cytoplasm
C1904936biological_processinterneuron migration
Functional Information from PROSITE/UniProt
site_idPS00374
Number of Residues7
DetailsMGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV
ChainResidueDetails
BILE559-VAL565

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS
ChainResidueDetails
AILE761-SER771

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF
ChainResidueDetails
BLEU166-PHE180
BILE208-VAL222
BLEU312-VAL326
BVAL396-CYS410

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS54
CLYS54
AGLY1140
AGLY1482

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER110
CSER110

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2640

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR2844

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2846

227344

PDB entries from 2024-11-13

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