8FBZ

Crystal Structure of apo human Glutathione Synthetase Y270E

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004363	molecular_function	glutathione synthase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006750	biological_process	glutathione biosynthetic process
A	0006979	biological_process	response to oxidative stress
A	0007399	biological_process	nervous system development
A	0016874	molecular_function	ligase activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0046686	biological_process	response to cadmium ion
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004363	molecular_function	glutathione synthase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006750	biological_process	glutathione biosynthetic process
B	0006979	biological_process	response to oxidative stress
B	0007399	biological_process	nervous system development
B	0016874	molecular_function	ligase activity
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043295	molecular_function	glutathione binding
B	0046686	biological_process	response to cadmium ion
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA2
Number of Residues	7
Details	M-CSA 498

Chain	Residue	Details
B	ARG125	electrostatic stabiliser
B	GLU144	metal ligand
B	ASN146	metal ligand
B	SER151	electrostatic stabiliser
B	LYS305	electrostatic stabiliser
B	LYS364	electrostatic stabiliser
B	ARG450	electrostatic stabiliser

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site_id	MCSA1
Number of Residues	7
Details	M-CSA 498

Chain	Residue	Details
A	ARG125	electrostatic stabiliser
A	GLU144	metal ligand
A	ASN146	metal ligand
A	SER151	electrostatic stabiliser
A	LYS305	electrostatic stabiliser
A	LYS364	electrostatic stabiliser
A	ARG450	electrostatic stabiliser

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