8FBZ
Crystal Structure of apo human Glutathione Synthetase Y270E
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004363 | molecular_function | glutathione synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006750 | biological_process | glutathione biosynthetic process |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0007399 | biological_process | nervous system development |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043295 | molecular_function | glutathione binding |
| A | 0046686 | biological_process | response to cadmium ion |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004363 | molecular_function | glutathione synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006750 | biological_process | glutathione biosynthetic process |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0007399 | biological_process | nervous system development |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043295 | molecular_function | glutathione binding |
| B | 0046686 | biological_process | response to cadmium ion |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ARG125 | |
| B | GLU368 | |
| B | TYR375 | |
| B | MET398 | |
| B | GLU425 | |
| B | ARG450 | |
| B | LYS452 | |
| B | ASP458 | |
| B | VAL461 | |
| A | ARG125 | |
| A | GLU144 | |
| B | GLU144 | |
| A | ASN146 | |
| A | ILE148 | |
| A | GLU214 | |
| A | GLN220 | |
| A | ARG267 | |
| A | LYS305 | |
| A | LYS364 | |
| A | GLU368 | |
| A | TYR375 | |
| A | MET398 | |
| B | ASN146 | |
| A | GLU425 | |
| A | ARG450 | |
| A | LYS452 | |
| A | ASP458 | |
| A | VAL461 | |
| B | ILE148 | |
| B | GLU214 | |
| B | GLN220 | |
| B | ARG267 | |
| B | LYS305 | |
| B | LYS364 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| B | ALA2 | |
| A | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER415 | |
| A | SER415 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 498 |
| Chain | Residue | Details |
| B | ARG125 | electrostatic stabiliser |
| B | GLU144 | metal ligand |
| B | ASN146 | metal ligand |
| B | SER151 | electrostatic stabiliser |
| B | LYS305 | electrostatic stabiliser |
| B | LYS364 | electrostatic stabiliser |
| B | GLU368 | metal ligand |
| B | GLY369 | electrostatic stabiliser |
| B | ARG450 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 498 |
| Chain | Residue | Details |
| A | ARG125 | electrostatic stabiliser |
| A | GLU144 | metal ligand |
| A | ASN146 | metal ligand |
| A | SER151 | electrostatic stabiliser |
| A | LYS305 | electrostatic stabiliser |
| A | LYS364 | electrostatic stabiliser |
| A | GLU368 | metal ligand |
| A | GLY369 | electrostatic stabiliser |
| A | ARG450 | electrostatic stabiliser |
