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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8F7S

Gi bound delta-opioid receptor in complex with deltorphin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0007218biological_processneuropeptide signaling pathway
A0010855molecular_functionadenylate cyclase inhibitor activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0034695biological_processresponse to prostaglandin E
A0036064cellular_componentciliary basal body
A0043303biological_processmast cell degranulation
A0043434biological_processresponse to peptide hormone
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0070098biological_processchemokine-mediated signaling pathway
A0072678biological_processT cell migration
A1901082biological_processpositive regulation of relaxation of smooth muscle
A1903998biological_processregulation of eating behavior
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
D0004930molecular_functionG protein-coupled receptor activity
D0004985molecular_functionG protein-coupled opioid receptor activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007218biological_processneuropeptide signaling pathway
D0008528molecular_functionG protein-coupled peptide receptor activity
D0010629biological_processnegative regulation of gene expression
D0016020cellular_componentmembrane
D0030672cellular_componentsynaptic vesicle membrane
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031982cellular_componentvesicle
D0032590cellular_componentdendrite membrane
D0033612molecular_functionreceptor serine/threonine kinase binding
D0035094biological_processresponse to nicotine
D0038003biological_processG protein-coupled opioid receptor signaling pathway
D0038046molecular_functionG protein-coupled enkephalin receptor activity
D0042734cellular_componentpresynaptic membrane
D0042755biological_processeating behavior
D0042923molecular_functionneuropeptide binding
D0043005cellular_componentneuron projection
D0043679cellular_componentaxon terminus
D0045211cellular_componentpostsynaptic membrane
D0045471biological_processresponse to ethanol
D0051881biological_processregulation of mitochondrial membrane potential
D0051924biological_processregulation of calcium ion transport
D0071363biological_processcellular response to growth factor stimulus
D0071456biological_processcellular response to hypoxia
D0097237biological_processcellular response to toxic substance
D0097444cellular_componentspine apparatus
D0098839cellular_componentpostsynaptic density membrane
D0098992cellular_componentneuronal dense core vesicle
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0001664molecular_functionG protein-coupled receptor binding
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005765cellular_componentlysosomal membrane
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005834cellular_componentheterotrimeric G-protein complex
F0005886cellular_componentplasma membrane
F0005938cellular_componentcell cortex
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
F0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
F0007218biological_processneuropeptide signaling pathway
F0010855molecular_functionadenylate cyclase inhibitor activity
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0019001molecular_functionguanyl nucleotide binding
F0019003molecular_functionGDP binding
F0030496cellular_componentmidbody
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0031749molecular_functionD2 dopamine receptor binding
F0031821molecular_functionG protein-coupled serotonin receptor binding
F0034695biological_processresponse to prostaglandin E
F0036064cellular_componentciliary basal body
F0043303biological_processmast cell degranulation
F0043434biological_processresponse to peptide hormone
F0045542biological_processpositive regulation of cholesterol biosynthetic process
F0046872molecular_functionmetal ion binding
F0051301biological_processcell division
F0060236biological_processregulation of mitotic spindle organization
F0070062cellular_componentextracellular exosome
F0070098biological_processchemokine-mediated signaling pathway
F0072678biological_processT cell migration
F1901082biological_processpositive regulation of relaxation of smooth muscle
F1903998biological_processregulation of eating behavior
F1904322biological_processcellular response to forskolin
F1904778biological_processpositive regulation of protein localization to cell cortex
R0004930molecular_functionG protein-coupled receptor activity
R0004985molecular_functionG protein-coupled opioid receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006955biological_processimmune response
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0008528molecular_functionG protein-coupled peptide receptor activity
R0010629biological_processnegative regulation of gene expression
R0016020cellular_componentmembrane
R0030672cellular_componentsynaptic vesicle membrane
R0031333biological_processnegative regulation of protein-containing complex assembly
R0031982cellular_componentvesicle
R0032590cellular_componentdendrite membrane
R0033612molecular_functionreceptor serine/threonine kinase binding
R0035094biological_processresponse to nicotine
R0038003biological_processG protein-coupled opioid receptor signaling pathway
R0038046molecular_functionG protein-coupled enkephalin receptor activity
R0042734cellular_componentpresynaptic membrane
R0042755biological_processeating behavior
R0042923molecular_functionneuropeptide binding
R0043005cellular_componentneuron projection
R0043679cellular_componentaxon terminus
R0045211cellular_componentpostsynaptic membrane
R0045471biological_processresponse to ethanol
R0051881biological_processregulation of mitochondrial membrane potential
R0051924biological_processregulation of calcium ion transport
R0071363biological_processcellular response to growth factor stimulus
R0071456biological_processcellular response to hypoxia
R0097237biological_processcellular response to toxic substance
R0097444cellular_componentspine apparatus
R0098839cellular_componentpostsynaptic density membrane
R0098992cellular_componentneuronal dense core vesicle
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMCVDRYIaV
ChainResidueDetails
RTHR134-VAL150
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU75-SER89
BILE162-ILE176
BLEU290-ALA304
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues98
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues88
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues62
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues13
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues9
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues7
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues5
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18434541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22383884","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

250059

PDB entries from 2026-03-04

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