Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8F2R

Human CCC complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005829	cellular_component	cytosol
A	0006289	biological_process	nucleotide-excision repair
A	0006351	biological_process	DNA-templated transcription
A	0006893	biological_process	Golgi to plasma membrane transport
A	0008289	molecular_function	lipid binding
A	0010008	cellular_component	endosome membrane
A	0015031	biological_process	protein transport
A	0019871	molecular_function	sodium channel inhibitor activity
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0031410	cellular_component	cytoplasmic vesicle
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
A	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032456	biological_process	endocytic recycling
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
A	0046872	molecular_function	metal ion binding
A	0048227	biological_process	plasma membrane to endosome transport
A	0055037	cellular_component	recycling endosome
A	0055070	biological_process	copper ion homeostasis
A	0070300	molecular_function	phosphatidic acid binding
A	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
A	1902306	biological_process	negative regulation of sodium ion transmembrane transport
A	2000009	biological_process	negative regulation of protein localization to cell surface
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0010008	cellular_component	endosome membrane
B	0032456	biological_process	endocytic recycling
B	0032991	cellular_component	protein-containing complex
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006351	biological_process	DNA-templated transcription
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0010008	cellular_component	endosome membrane
C	0032456	biological_process	endocytic recycling
C	0032991	cellular_component	protein-containing complex
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0007165	biological_process	signal transduction
D	0010008	cellular_component	endosome membrane
D	0032456	biological_process	endocytic recycling
D	0032991	cellular_component	protein-containing complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0010008	cellular_component	endosome membrane
E	0032456	biological_process	endocytic recycling
E	0032991	cellular_component	protein-containing complex
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0007165	biological_process	signal transduction
F	0010008	cellular_component	endosome membrane
F	0032456	biological_process	endocytic recycling
F	0032991	cellular_component	protein-containing complex
F	0051059	molecular_function	NF-kappaB binding
G	0005515	molecular_function	protein binding
G	0006351	biological_process	DNA-templated transcription
G	0010008	cellular_component	endosome membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0032456	biological_process	endocytic recycling
G	0032991	cellular_component	protein-containing complex
G	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0051059	molecular_function	NF-kappaB binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006351	biological_process	DNA-templated transcription
H	0007165	biological_process	signal transduction
H	0010008	cellular_component	endosome membrane
H	0032456	biological_process	endocytic recycling
H	0032991	cellular_component	protein-containing complex
H	0051059	molecular_function	NF-kappaB binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0006351	biological_process	DNA-templated transcription
I	0006811	biological_process	monoatomic ion transport
I	0006814	biological_process	sodium ion transport
I	0010008	cellular_component	endosome membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0032456	biological_process	endocytic recycling
I	0032991	cellular_component	protein-containing complex
I	0034774	cellular_component	secretory granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006351	biological_process	DNA-templated transcription
J	0010008	cellular_component	endosome membrane
J	0032456	biological_process	endocytic recycling
J	0032991	cellular_component	protein-containing complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	681
Details	Domain: {"description":"COMM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00602","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	121
Details	Region: {"description":"Sufficient for interaction with SLC12A2","evidences":[{"source":"PubMed","id":"23515529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)