8F0H

Structure of SARS-CoV-2 spike with antibody Fabs 2A10 and 1H2 (Local refinement of the RBD and Fabs 1H2 and 2A10)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019062	biological_process	virion attachment to host cell
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0020002	cellular_component	host cell plasma membrane
C	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0039660	molecular_function	structural constituent of virion
C	0039663	biological_process	membrane fusion involved in viral entry into host cell
C	0042802	molecular_function	identical protein binding
C	0043655	cellular_component	host extracellular space
C	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
C	0044228	cellular_component	host cell surface
C	0044423	cellular_component	virion component
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0046718	biological_process	symbiont entry into host cell
C	0046789	molecular_function	host cell surface receptor binding
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0048018	molecular_function	receptor ligand activity
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0055036	cellular_component	virion membrane
C	0061025	biological_process	membrane fusion
C	0075509	biological_process	endocytosis involved in viral entry into host cell
C	0098670	biological_process	entry receptor-mediated virion attachment to host cell
C	0141146	biological_process	symbiont-mediated disruption of host tissue

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PgkTArITCGGS

Chain	Residue	Details
D	PRO14-SER25

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Region: {"description":"Integrin-binding motif;","evidences":[{"source":"PubMed","id":"33102950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	71
Details	Region: {"description":"Receptor-binding motif; binding to human ACE2","evidences":[{"source":"UniProtKB","id":"P59594","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Immunodominant HLA epitope recognized by the CD8+; called NF9 peptide","evidences":[{"source":"PubMed","id":"34171266","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"35108439","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32155444","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32366695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32979942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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