Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8EZ9

Dimeric complex of DNA-PKcs

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000460	biological_process	maturation of 5.8S rRNA
C	0000723	biological_process	telomere maintenance
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0001756	biological_process	somitogenesis
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0002218	biological_process	activation of innate immune response
C	0002326	biological_process	B cell lineage commitment
C	0002327	biological_process	immature B cell differentiation
C	0002328	biological_process	pro-B cell differentiation
C	0002360	biological_process	T cell lineage commitment
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003723	molecular_function	RNA binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004677	molecular_function	DNA-dependent protein kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005667	cellular_component	transcription regulator complex
C	0005730	cellular_component	nucleolus
C	0005829	cellular_component	cytosol
C	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006310	biological_process	DNA recombination
C	0006338	biological_process	chromatin remodeling
C	0006468	biological_process	protein phosphorylation
C	0006974	biological_process	DNA damage response
C	0007420	biological_process	brain development
C	0007507	biological_process	heart development
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0010212	biological_process	response to ionizing radiation
C	0010332	biological_process	response to gamma radiation
C	0016020	cellular_component	membrane
C	0016233	biological_process	telomere capping
C	0016301	molecular_function	kinase activity
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0018107	biological_process	peptidyl-threonine phosphorylation
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0030098	biological_process	lymphocyte differentiation
C	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
C	0031648	biological_process	protein destabilization
C	0032040	cellular_component	small-subunit processome
C	0032869	biological_process	cellular response to insulin stimulus
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0033077	biological_process	T cell differentiation in thymus
C	0033151	biological_process	V(D)J recombination
C	0033152	biological_process	immunoglobulin V(D)J recombination
C	0033153	biological_process	T cell receptor V(D)J recombination
C	0034462	biological_process	small-subunit processome assembly
C	0034511	molecular_function	U3 snoRNA binding
C	0035234	biological_process	ectopic germ cell programmed cell death
C	0035979	molecular_function	histone H2AXS139 kinase activity
C	0036211	biological_process	protein modification process
C	0042254	biological_process	ribosome biogenesis
C	0042752	biological_process	regulation of circadian rhythm
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0045087	biological_process	innate immune response
C	0045621	biological_process	positive regulation of lymphocyte differentiation
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0045727	biological_process	positive regulation of translation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048511	biological_process	rhythmic process
C	0048660	biological_process	regulation of smooth muscle cell proliferation
C	0050678	biological_process	regulation of epithelial cell proliferation
C	0051171	biological_process	obsolete regulation of nitrogen compound metabolic process
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070418	cellular_component	DNA-dependent protein kinase complex
C	0070419	cellular_component	nonhomologous end joining complex
C	0080090	biological_process	regulation of primary metabolic process
C	0080135	biological_process	regulation of cellular response to stress
C	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
C	0106310	molecular_function	protein serine kinase activity
C	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
C	1902036	biological_process	regulation of hematopoietic stem cell differentiation
C	1905221	biological_process	positive regulation of platelet formation
C	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
L	0000460	biological_process	maturation of 5.8S rRNA
L	0000723	biological_process	telomere maintenance
L	0000781	cellular_component	chromosome, telomeric region
L	0000785	cellular_component	chromatin
L	0001756	biological_process	somitogenesis
L	0001933	biological_process	negative regulation of protein phosphorylation
L	0002218	biological_process	activation of innate immune response
L	0002326	biological_process	B cell lineage commitment
L	0002327	biological_process	immature B cell differentiation
L	0002328	biological_process	pro-B cell differentiation
L	0002360	biological_process	T cell lineage commitment
L	0003677	molecular_function	DNA binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003723	molecular_function	RNA binding
L	0004672	molecular_function	protein kinase activity
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0004677	molecular_function	DNA-dependent protein kinase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005667	cellular_component	transcription regulator complex
L	0005730	cellular_component	nucleolus
L	0005829	cellular_component	cytosol
L	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
L	0006281	biological_process	DNA repair
L	0006302	biological_process	double-strand break repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0006338	biological_process	chromatin remodeling
L	0006468	biological_process	protein phosphorylation
L	0006974	biological_process	DNA damage response
L	0007420	biological_process	brain development
L	0007507	biological_process	heart development
L	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
L	0010212	biological_process	response to ionizing radiation
L	0010332	biological_process	response to gamma radiation
L	0016020	cellular_component	membrane
L	0016233	biological_process	telomere capping
L	0016301	molecular_function	kinase activity
L	0018105	biological_process	peptidyl-serine phosphorylation
L	0018107	biological_process	peptidyl-threonine phosphorylation
L	0019899	molecular_function	enzyme binding
L	0019904	molecular_function	protein domain specific binding
L	0030098	biological_process	lymphocyte differentiation
L	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
L	0031648	biological_process	protein destabilization
L	0032040	cellular_component	small-subunit processome
L	0032869	biological_process	cellular response to insulin stimulus
L	0032991	cellular_component	protein-containing complex
L	0032993	cellular_component	protein-DNA complex
L	0033077	biological_process	T cell differentiation in thymus
L	0033151	biological_process	V(D)J recombination
L	0033152	biological_process	immunoglobulin V(D)J recombination
L	0033153	biological_process	T cell receptor V(D)J recombination
L	0034462	biological_process	small-subunit processome assembly
L	0034511	molecular_function	U3 snoRNA binding
L	0035234	biological_process	ectopic germ cell programmed cell death
L	0035979	molecular_function	histone H2AXS139 kinase activity
L	0036211	biological_process	protein modification process
L	0042254	biological_process	ribosome biogenesis
L	0042752	biological_process	regulation of circadian rhythm
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0045087	biological_process	innate immune response
L	0045621	biological_process	positive regulation of lymphocyte differentiation
L	0045648	biological_process	positive regulation of erythrocyte differentiation
L	0045727	biological_process	positive regulation of translation
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0048511	biological_process	rhythmic process
L	0048660	biological_process	regulation of smooth muscle cell proliferation
L	0050678	biological_process	regulation of epithelial cell proliferation
L	0051171	biological_process	obsolete regulation of nitrogen compound metabolic process
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0070418	cellular_component	DNA-dependent protein kinase complex
L	0070419	cellular_component	nonhomologous end joining complex
L	0080090	biological_process	regulation of primary metabolic process
L	0080135	biological_process	regulation of cellular response to stress
L	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
L	0106310	molecular_function	protein serine kinase activity
L	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
L	1902036	biological_process	regulation of hematopoietic stem cell differentiation
L	1905221	biological_process	positive regulation of platelet formation
L	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
L	VAL3752-GLN3766

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
L	SER3907-ASN3927

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by caspase-3 => ECO:0000269\|PubMed:8804412

Chain	Residue	Details
L	ASP2020
C	ASP2020

site_id	SWS_FT_FI2
Number of Residues	20
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
L	LYS117
L	LYS3642
C	LYS117
C	LYS828
C	LYS1209
C	LYS1970
C	LYS2259
C	LYS3241
C	LYS3260
C	LYS3621
C	LYS3638
L	LYS828
C	LYS3642
L	LYS1209
L	LYS1970
L	LYS2259
L	LYS3241
L	LYS3260
L	LYS3621
L	LYS3638

site_id	SWS_FT_FI3
Number of Residues	14
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	SER511
C	SER841
C	SER1065
C	SER2789
C	SER3731
C	SER3821
L	SER687
L	SER841
L	SER1065
L	SER2789
L	SER3731
L	SER3821
C	SER511
C	SER687

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19369195

Chain	Residue	Details
L	SER893
C	SER893

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269\|PubMed:14734805, ECO:0000269\|PubMed:22977523, ECO:0000269\|PubMed:34352203

Chain	Residue	Details
L	SER2056
C	SER2056

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	THR2535
C	THR2535

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269\|PubMed:12186630, ECO:0000269\|PubMed:12231622, ECO:0000269\|PubMed:14734805, ECO:0000269\|PubMed:32103174, ECO:0000269\|PubMed:34352203

Chain	Residue	Details
L	THR2609
C	THR2609

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269\|PubMed:12186630, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
L	SER2612
C	SER2612

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269\|PubMed:12186630, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	THR2638
L	THR2647
C	THR2638
C	THR2647

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	SER3205
C	SER3205

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
L	SER4026
C	SER4026

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)