8EYO

Crystal Structure of Human Mitochondrial NADP+ Malic Enzyme 3 with NADP bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004470	molecular_function	malic enzyme activity
A	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006090	biological_process	pyruvate metabolic process
A	0006108	biological_process	malate metabolic process
A	0008948	molecular_function	oxaloacetate decarboxylase activity
A	0009060	biological_process	aerobic respiration
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
A	0072592	biological_process	oxygen metabolic process
B	0004470	molecular_function	malic enzyme activity
B	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006090	biological_process	pyruvate metabolic process
B	0006108	biological_process	malate metabolic process
B	0008948	molecular_function	oxaloacetate decarboxylase activity
B	0009060	biological_process	aerobic respiration
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0070401	molecular_function	NADP+ binding
B	0072592	biological_process	oxygen metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00331
Number of Residues	17
Details	MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVaVAGIL

Chain	Residue	Details
A	PHE301-LEU317

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	TYR137
B	TYR137

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	LYS208
B	LYS208

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG190
B	ASN443
A	GLU280
A	ASP281
A	ASP304
A	ASN443
B	ARG190
B	GLU280
B	ASP281
B	ASP304

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for activity => ECO:0000250

Chain	Residue	Details
A	ASP304
B	ASP304

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06801

Chain	Residue	Details
A	SER371
B	SER371

---