8EVA
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition state 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0001750 | cellular_component | photoreceptor outer segment |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005222 | molecular_function | intracellularly cAMP-activated cation channel activity |
| D | 0005223 | molecular_function | intracellularly cGMP-activated cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0007165 | biological_process | signal transduction |
| D | 0007601 | biological_process | visual perception |
| D | 0016020 | cellular_component | membrane |
| D | 0017071 | cellular_component | intracellular cyclic nucleotide activated cation channel complex |
| D | 0030553 | molecular_function | cGMP binding |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0098655 | biological_process | monoatomic cation transmembrane transport |
| D | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGKeMYIIneG |
| Chain | Residue | Details |
| A | ILE509-GLY525 | |
| D | VAL551-GLY567 |
| site_id | PS00889 |
| Number of Residues | 24 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSIlnikgsksgnrRTAnIrS |
| Chain | Residue | Details |
| A | PHE547-SER570 | |
| D | PHE590-ALA610 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | LEU219-PHE242 | |
| B | TRP171-PHE192 | |
| C | TRP171-PHE192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| D | PRO243-ASN249 | |
| D | GLY318-ASN320 | |
| D | TYR372-GLU393 | |
| B | ASP193-GLU198 | |
| B | GLY267-TYR270 | |
| B | PHE322-ARG347 | |
| C | ASP193-GLU198 | |
| C | GLY267-TYR270 | |
| C | PHE322-ARG347 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | ILE250-PHE270 | |
| B | TYR199-LEU219 | |
| C | TYR199-LEU219 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 403 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| D | ILE271-LYS299 | |
| D | GLU336-ALA348 | |
| D | GLY446-GLN809 | |
| B | VAL220-THR246 | |
| B | ASP289-PRO298 | |
| B | SER404-GLN694 | |
| C | VAL220-THR246 | |
| C | ASP289-PRO298 | |
| C | SER404-GLN694 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | PHE300-PHE317 | |
| B | THR247-VAL266 | |
| C | THR247-VAL266 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | PRO321-PHE335 | |
| B | PRO271-PHE288 | |
| C | PRO271-PHE288 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S5 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | TYR349-TYR371 | |
| B | ASN299-TYR321 | |
| C | ASN299-TYR321 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=P-helix => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | TYR394-ILE420 | |
| B | LEU348-TYR378 | |
| C | LEU348-TYR378 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS |
| Chain | Residue | Details |
| D | VAL421-ILE445 | |
| B | LEU379-ILE403 | |
| C | LEU379-ILE403 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37463923, ECO:0007744|PDB:8EUC |
| Chain | Residue | Details |
| D | GLY591 | |
| B | ARG564 | |
| B | THR565 | |
| B | ASP609 | |
| C | GLY548 | |
| C | GLU549 | |
| C | SER551 | |
| C | ARG564 | |
| C | THR565 | |
| C | ASP609 | |
| D | GLU592 | |
| D | ARG604 | |
| D | THR605 | |
| A | THR565 | |
| A | ASP609 | |
| B | GLY548 | |
| B | GLU549 | |
| B | SER551 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | SITE: Central gate => ECO:0000305|PubMed:34969976 |
| Chain | Residue | Details |
| D | PHE434 | |
| D | ILE438 | |
| B | PHE392 | |
| B | VAL396 | |
| C | PHE392 | |
| C | VAL396 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | SITE: Occludes the pore below the central gate => ECO:0000305|PubMed:34969976 |
| Chain | Residue | Details |
| D | ARG442 | |
| B | ASN339 | |
| C | ASN339 |
