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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8EVA

Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition state 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0016020cellular_componentmembrane
A0055085biological_processtransmembrane transport
B0005216molecular_functionmonoatomic ion channel activity
B0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0016020cellular_componentmembrane
B0055085biological_processtransmembrane transport
C0005216molecular_functionmonoatomic ion channel activity
C0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0016020cellular_componentmembrane
C0055085biological_processtransmembrane transport
D0000166molecular_functionnucleotide binding
D0001750cellular_componentphotoreceptor outer segment
D0005216molecular_functionmonoatomic ion channel activity
D0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0007165biological_processsignal transduction
D0007601biological_processvisual perception
D0016020cellular_componentmembrane
D0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
D0030553molecular_functioncGMP binding
D0034220biological_processmonoatomic ion transmembrane transport
D0055085biological_processtransmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D1902495cellular_componenttransmembrane transporter complex
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VCkKGEiGKeMYIIkhG
ChainResidueDetails
DVAL551-GLY567
AILE509-GLY525
site_idPS00889
Number of Residues21
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSLlaagggnr...RTAnVvA
ChainResidueDetails
DPHE590-ALA610
APHE547-SER570
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues86
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues122
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues145
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues65
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues116
DetailsTransmembrane: {"description":"Helical; Name=P-helix","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues423
DetailsRegion: {"description":"Ion conduction pathway","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues307
DetailsRegion: {"description":"C-linker","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues240
DetailsRegion: {"description":"Cyclic nucleotide-binding domain","evidences":[{"source":"PubMed","id":"37463923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EUC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37463923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EUC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsSite: {"description":"Central gate","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GalNAc...) asparagine","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"Occludes the pore below the central gate","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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