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8ETP

Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
A0005222molecular_functionintracellularly cAMP-activated cation channel activity
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006814biological_processsodium ion transport
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0017022molecular_functionmyosin binding
A0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
A0030425cellular_componentdendrite
A0030553molecular_functioncGMP binding
A0032026biological_processresponse to magnesium ion
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0043025cellular_componentneuronal cell body
A0043194cellular_componentaxon initial segment
A0043204cellular_componentperikaryon
A0044877molecular_functionprotein-containing complex binding
A0045296molecular_functioncadherin binding
A0051591biological_processresponse to cAMP
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0097386cellular_componentglial cell projection
A0098655biological_processmonoatomic cation transmembrane transport
A0098659biological_processinorganic cation import across plasma membrane
A1902495cellular_componenttransmembrane transporter complex
B0005216molecular_functionmonoatomic ion channel activity
B0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
B0005222molecular_functionintracellularly cAMP-activated cation channel activity
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006814biological_processsodium ion transport
B0007165biological_processsignal transduction
B0007601biological_processvisual perception
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0017022molecular_functionmyosin binding
B0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
B0030425cellular_componentdendrite
B0030553molecular_functioncGMP binding
B0032026biological_processresponse to magnesium ion
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0043025cellular_componentneuronal cell body
B0043194cellular_componentaxon initial segment
B0043204cellular_componentperikaryon
B0044877molecular_functionprotein-containing complex binding
B0045296molecular_functioncadherin binding
B0051591biological_processresponse to cAMP
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0097386cellular_componentglial cell projection
B0098655biological_processmonoatomic cation transmembrane transport
B0098659biological_processinorganic cation import across plasma membrane
B1902495cellular_componenttransmembrane transporter complex
C0005216molecular_functionmonoatomic ion channel activity
C0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
C0005222molecular_functionintracellularly cAMP-activated cation channel activity
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0006814biological_processsodium ion transport
C0007165biological_processsignal transduction
C0007601biological_processvisual perception
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0017022molecular_functionmyosin binding
C0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
C0030425cellular_componentdendrite
C0030553molecular_functioncGMP binding
C0032026biological_processresponse to magnesium ion
C0034220biological_processmonoatomic ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0043025cellular_componentneuronal cell body
C0043194cellular_componentaxon initial segment
C0043204cellular_componentperikaryon
C0044877molecular_functionprotein-containing complex binding
C0045296molecular_functioncadherin binding
C0051591biological_processresponse to cAMP
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0097386cellular_componentglial cell projection
C0098655biological_processmonoatomic cation transmembrane transport
C0098659biological_processinorganic cation import across plasma membrane
C1902495cellular_componenttransmembrane transporter complex
D0001750cellular_componentphotoreceptor outer segment
D0005216molecular_functionmonoatomic ion channel activity
D0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0007165biological_processsignal transduction
D0007601biological_processvisual perception
D0016020cellular_componentmembrane
D0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
D0030553molecular_functioncGMP binding
D0034220biological_processmonoatomic ion transmembrane transport
D0044877molecular_functionprotein-containing complex binding
D0055085biological_processtransmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D1902495cellular_componenttransmembrane transporter complex
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VCkKGEiGKeMYIIkhG
ChainResidueDetails
DVAL551-GLY567
AILE509-GLY525

site_idPS00889
Number of Residues21
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSLlaagggnr...RTAnVvA
ChainResidueDetails
DPHE590-ALA610
APHE547-SER570

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues620
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
DMET1-TYR218
CVAL220-THR246
CASP289-PRO298
CSER404-GLN694
DILE271-LYS299
DGLU336-ALA348
DGLY446-GLN809
BMET1-ARG170
BVAL220-THR246
BASP289-PRO298
BSER404-GLN694
CMET1-ARG170

site_idSWS_FT_FI2
Number of Residues23
DetailsTRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DLEU219-PHE242
BTRP171-PHE192
CTRP171-PHE192

site_idSWS_FT_FI3
Number of Residues29
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
DPRO243-ASN249
DGLY318-ASN320
DTYR372-GLU393
BASP193-GLU198
BGLY267-TYR270
BPHE322-ARG347
CASP193-GLU198
CGLY267-TYR270
CPHE322-ARG347

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DILE250-PHE270
BTYR199-LEU219
CTYR199-LEU219

site_idSWS_FT_FI5
Number of Residues17
DetailsTRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DPHE300-PHE317
BTHR247-VAL266
CTHR247-VAL266

site_idSWS_FT_FI6
Number of Residues14
DetailsTRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DPRO321-PHE335
BPRO271-PHE288
CPRO271-PHE288

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=S5 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DTYR349-TYR371
BASN299-TYR321
CASN299-TYR321

site_idSWS_FT_FI8
Number of Residues26
DetailsTRANSMEM: Helical; Name=P-helix => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DTYR394-ILE420
BLEU348-TYR378
CLEU348-TYR378

site_idSWS_FT_FI9
Number of Residues24
DetailsTRANSMEM: Helical; Name=S6 => ECO:0000269|PubMed:34969976, ECO:0007744|PDB:7RHS
ChainResidueDetails
DVAL421-ILE445
BLEU379-ILE403
CLEU379-ILE403

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:37463923, ECO:0007744|PDB:8EUC
ChainResidueDetails
DGLY591
BARG564
BTHR565
BASP609
CGLY548
CGLU549
CSER551
CARG564
CTHR565
CASP609
DGLU592
DARG604
DTHR605
ATHR565
AASP609
BGLY548
BGLU549
BSER551

site_idSWS_FT_FI11
Number of Residues2
DetailsSITE: Central gate => ECO:0000305|PubMed:34969976
ChainResidueDetails
DPHE434
DILE438
BPHE392
BVAL396
CPHE392
CVAL396

site_idSWS_FT_FI12
Number of Residues1
DetailsSITE: Occludes the pore below the central gate => ECO:0000305|PubMed:34969976
ChainResidueDetails
DARG442
BASN339
CASN339

227344

PDB entries from 2024-11-13

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