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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ETP

Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005216molecular_functionmonoatomic ion channel activity
A0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
A0005222molecular_functionintracellularly cAMP-activated cation channel activity
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006814biological_processsodium ion transport
A0006816biological_processcalcium ion transport
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0017022molecular_functionmyosin binding
A0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
A0030425cellular_componentdendrite
A0030553molecular_functioncGMP binding
A0032026biological_processresponse to magnesium ion
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0043025cellular_componentneuronal cell body
A0043194cellular_componentaxon initial segment
A0043204cellular_componentperikaryon
A0045296molecular_functioncadherin binding
A0051591biological_processresponse to cAMP
A0055085biological_processtransmembrane transport
A0060041biological_processretina development in camera-type eye
A0070588biological_processcalcium ion transmembrane transport
A0097386cellular_componentglial cell projection
A0098655biological_processmonoatomic cation transmembrane transport
A0098659biological_processinorganic cation import across plasma membrane
A1902495cellular_componenttransmembrane transporter complex
B0000166molecular_functionnucleotide binding
B0005216molecular_functionmonoatomic ion channel activity
B0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
B0005222molecular_functionintracellularly cAMP-activated cation channel activity
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006814biological_processsodium ion transport
B0006816biological_processcalcium ion transport
B0007165biological_processsignal transduction
B0007601biological_processvisual perception
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0017022molecular_functionmyosin binding
B0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
B0030425cellular_componentdendrite
B0030553molecular_functioncGMP binding
B0032026biological_processresponse to magnesium ion
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0043025cellular_componentneuronal cell body
B0043194cellular_componentaxon initial segment
B0043204cellular_componentperikaryon
B0045296molecular_functioncadherin binding
B0051591biological_processresponse to cAMP
B0055085biological_processtransmembrane transport
B0060041biological_processretina development in camera-type eye
B0070588biological_processcalcium ion transmembrane transport
B0097386cellular_componentglial cell projection
B0098655biological_processmonoatomic cation transmembrane transport
B0098659biological_processinorganic cation import across plasma membrane
B1902495cellular_componenttransmembrane transporter complex
C0000166molecular_functionnucleotide binding
C0005216molecular_functionmonoatomic ion channel activity
C0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
C0005222molecular_functionintracellularly cAMP-activated cation channel activity
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0006814biological_processsodium ion transport
C0006816biological_processcalcium ion transport
C0007165biological_processsignal transduction
C0007601biological_processvisual perception
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0017022molecular_functionmyosin binding
C0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
C0030425cellular_componentdendrite
C0030553molecular_functioncGMP binding
C0032026biological_processresponse to magnesium ion
C0034220biological_processmonoatomic ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0043025cellular_componentneuronal cell body
C0043194cellular_componentaxon initial segment
C0043204cellular_componentperikaryon
C0045296molecular_functioncadherin binding
C0051591biological_processresponse to cAMP
C0055085biological_processtransmembrane transport
C0060041biological_processretina development in camera-type eye
C0070588biological_processcalcium ion transmembrane transport
C0097386cellular_componentglial cell projection
C0098655biological_processmonoatomic cation transmembrane transport
C0098659biological_processinorganic cation import across plasma membrane
C1902495cellular_componenttransmembrane transporter complex
D0000166molecular_functionnucleotide binding
D0001750cellular_componentphotoreceptor outer segment
D0005216molecular_functionmonoatomic ion channel activity
D0005221molecular_functionintracellularly cyclic nucleotide-activated monoatomic cation channel activity
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0007165biological_processsignal transduction
D0007601biological_processvisual perception
D0016020cellular_componentmembrane
D0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
D0030553molecular_functioncGMP binding
D0034220biological_processmonoatomic ion transmembrane transport
D0055085biological_processtransmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D1902495cellular_componenttransmembrane transporter complex
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGKeMYIIneG
ChainResidueDetails
AILE509-GLY525
DVAL551-GLY567
site_idPS00889
Number of Residues24
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSIlnikgsksgnrRTAnIrS
ChainResidueDetails
APHE547-SER570
DPHE590-ALA610
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues86
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues128
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues145
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues74
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues65
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues116
DetailsTransmembrane: {"description":"Helical; Name=P-helix","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues423
DetailsRegion: {"description":"Ion conduction pathway","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues12
DetailsRegion: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues307
DetailsRegion: {"description":"C-linker","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues360
DetailsRegion: {"description":"Cyclic nucleotide-binding domain","evidences":[{"source":"PubMed","id":"37463923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EUC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37463923","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8EUC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsSite: {"description":"Central gate","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GalNAc...) asparagine","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues116
DetailsRegion: {"description":"Cyclic nucleotide-binding domain","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37463923","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EUC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsSite: {"description":"Occludes the pore below the central gate","evidences":[{"source":"PubMed","id":"34969976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-07-09

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