8ET9

Cryo-EM structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005275	molecular_function	amine transmembrane transporter activity
A	0005277	molecular_function	acetylcholine transmembrane transporter activity
A	0005326	molecular_function	neurotransmitter transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006836	biological_process	neurotransmitter transport
A	0006837	biological_process	serotonin transport
A	0008504	molecular_function	monoamine transmembrane transporter activity
A	0009925	cellular_component	basal plasma membrane
A	0015132	molecular_function	prostaglandin transmembrane transporter activity
A	0015179	molecular_function	L-amino acid transmembrane transporter activity
A	0015214	molecular_function	pyrimidine nucleoside transmembrane transporter activity
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015234	molecular_function	thiamine transmembrane transporter activity
A	0015489	molecular_function	putrescine transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015606	molecular_function	spermidine transmembrane transporter activity
A	0015651	molecular_function	quaternary ammonium group transmembrane transporter activity
A	0015695	biological_process	organic cation transport
A	0015697	biological_process	quaternary ammonium group transport
A	0015732	biological_process	prostaglandin transport
A	0015837	biological_process	amine transport
A	0015847	biological_process	putrescine transport
A	0015848	biological_process	spermidine transport
A	0015870	biological_process	acetylcholine transport
A	0015871	biological_process	choline transport
A	0015872	biological_process	dopamine transport
A	0015874	biological_process	norepinephrine transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0019534	molecular_function	toxin transmembrane transporter activity
A	0022857	molecular_function	transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0048241	biological_process	epinephrine transport
A	0051608	biological_process	histamine transport
A	0051610	biological_process	serotonin uptake
A	0051615	biological_process	histamine uptake
A	0051620	biological_process	norepinephrine uptake
A	0055085	biological_process	transmembrane transport
A	0061459	molecular_function	L-arginine transmembrane transporter activity
A	0070062	cellular_component	extracellular exosome
A	0071934	biological_process	thiamine transmembrane transport
A	0072530	biological_process	purine-containing compound transmembrane transport
A	0089718	biological_process	amino acid import across plasma membrane
A	0090494	biological_process	dopamine uptake
A	0097638	biological_process	L-arginine import across plasma membrane
A	0098793	cellular_component	presynapse
A	0140115	biological_process	export across plasma membrane
A	0150104	biological_process	transport across blood-brain barrier
A	1902475	biological_process	L-alpha-amino acid transmembrane transport
A	1903711	biological_process	spermidine transmembrane transport
A	1903826	biological_process	L-arginine transmembrane transport
A	1990748	biological_process	cellular detoxification

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. IGYIADRFGRKlcllv.T

Chain	Residue	Details
A	ILE167-THR183
A	ILE394-ALA410

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	136
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	31
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"Proline-rich sequence","evidences":[{"source":"PubMed","id":"26979622","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations","evidences":[{"source":"UniProtKB","id":"Q9R0W2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---