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8ET9

Cryo-EM structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium

Functional Information from GO Data
ChainGOidnamespacecontents
A0005275molecular_functionamine transmembrane transporter activity
A0005277molecular_functionacetylcholine transmembrane transporter activity
A0005326molecular_functionneurotransmitter transmembrane transporter activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006836biological_processneurotransmitter transport
A0006837biological_processserotonin transport
A0007589biological_processbody fluid secretion
A0008504molecular_functionmonoamine transmembrane transporter activity
A0008514molecular_functionorganic anion transmembrane transporter activity
A0009925cellular_componentbasal plasma membrane
A0015101molecular_functionorganic cation transmembrane transporter activity
A0015132molecular_functionprostaglandin transmembrane transporter activity
A0015179molecular_functionL-amino acid transmembrane transporter activity
A0015214molecular_functionpyrimidine nucleoside transmembrane transporter activity
A0015220molecular_functioncholine transmembrane transporter activity
A0015234molecular_functionthiamine transmembrane transporter activity
A0015489molecular_functionputrescine transmembrane transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015606molecular_functionspermidine transmembrane transporter activity
A0015651molecular_functionquaternary ammonium group transmembrane transporter activity
A0015695biological_processorganic cation transport
A0015697biological_processquaternary ammonium group transport
A0015732biological_processprostaglandin transport
A0015837biological_processamine transport
A0015847biological_processputrescine transport
A0015848biological_processspermidine transport
A0015870biological_processacetylcholine transport
A0015871biological_processcholine transport
A0015872biological_processdopamine transport
A0015874biological_processnorepinephrine transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0019534molecular_functiontoxin transmembrane transporter activity
A0022857molecular_functiontransmembrane transporter activity
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0048241biological_processepinephrine transport
A0051608biological_processhistamine transport
A0051610biological_processserotonin uptake
A0051615biological_processhistamine uptake
A0051620biological_processnorepinephrine uptake
A0055085biological_processtransmembrane transport
A0061459molecular_functionL-arginine transmembrane transporter activity
A0070062cellular_componentextracellular exosome
A0071934biological_processthiamine transmembrane transport
A0072530biological_processpurine-containing compound transmembrane transport
A0089718biological_processamino acid import across plasma membrane
A0090494biological_processdopamine uptake
A0097638biological_processL-arginine import across plasma membrane
A0098793cellular_componentpresynapse
A0140115biological_processexport across plasma membrane
A0150104biological_processtransport across blood-brain barrier
A1902475biological_processL-alpha-amino acid transmembrane transport
A1903711biological_processspermidine transmembrane transport
A1903826biological_processL-arginine transmembrane transport
A1990748biological_processcellular detoxification
A1990962biological_processxenobiotic transport across blood-brain barrier
Functional Information from PROSITE/UniProt
site_idPS00216
Number of Residues17
DetailsSUGAR_TRANSPORT_1 Sugar transport proteins signature 1. IGYIADRFGRKlcllv.T
ChainResidueDetails
AILE167-THR183
AILE394-ALA410

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues154
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-THR22
AASP172-LYS177
AGLY230-GLY238
AGLU285-THR348
ATHR397-ALA414
AARG463-ASN464
AGLU516-ASN555

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE23-LEU43
AGLY442-ILE462
ALEU465-VAL485
ALEU495-PRO515
ALEU151-ALA171
ALEU178-PRO198
AILE209-VAL229
AILE239-ILE259
ATRP264-PRO284
ALEU349-MET369
AILE376-LEU396
AGLY415-VAL435

site_idSWS_FT_FI3
Number of Residues136
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLY44-ASP150
AASN199-LEU208
APRO260-ARG263
AGLY370-ASN375
AALA436-MET441
ATYR486-GLU494

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations => ECO:0000250|UniProtKB:Q9R0W2
ChainResidueDetails
ACYS451

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN72

227111

PDB entries from 2024-11-06

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