8ET2

CryoEM structure of the GSDMB pore

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1704
Details	TRANSMEM: Beta stranded => ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125, ECO:0007744|PDB:8EFP, ECO:0007744|PDB:8ET1, ECO:0007744|PDB:8ET2, ECO:0007744|PDB:8GTJ, ECO:0007744|PDB:8GTN

Chain	Residue	Details
A	GLU83-PRO101
C	LYS102-ILE125
C	GLU167-SER183
C	GLN184-THR198
D	GLU83-PRO101
D	LYS102-ILE125
D	GLU167-SER183
D	GLN184-THR198
E	GLU83-PRO101
E	LYS102-ILE125
E	GLU167-SER183
A	LYS102-ILE125
E	GLN184-THR198
F	GLU83-PRO101
F	LYS102-ILE125
F	GLU167-SER183
F	GLN184-THR198
G	GLU83-PRO101
G	LYS102-ILE125
G	GLU167-SER183
G	GLN184-THR198
H	GLU83-PRO101
A	GLU167-SER183
H	LYS102-ILE125
H	GLU167-SER183
H	GLN184-THR198
I	GLU83-PRO101
I	LYS102-ILE125
I	GLU167-SER183
I	GLN184-THR198
J	GLU83-PRO101
J	LYS102-ILE125
J	GLU167-SER183
A	GLN184-THR198
J	GLN184-THR198
K	GLU83-PRO101
K	LYS102-ILE125
K	GLU167-SER183
K	GLN184-THR198
L	GLU83-PRO101
L	LYS102-ILE125
L	GLU167-SER183
L	GLN184-THR198
M	GLU83-PRO101
B	GLU83-PRO101
M	LYS102-ILE125
M	GLU167-SER183
M	GLN184-THR198
N	GLU83-PRO101
N	LYS102-ILE125
N	GLU167-SER183
N	GLN184-THR198
O	GLU83-PRO101
O	LYS102-ILE125
O	GLU167-SER183
B	LYS102-ILE125
O	GLN184-THR198
P	GLU83-PRO101
P	LYS102-ILE125
P	GLU167-SER183
P	GLN184-THR198
Q	GLU83-PRO101
Q	LYS102-ILE125
Q	GLU167-SER183
Q	GLN184-THR198
R	GLU83-PRO101
B	GLU167-SER183
R	LYS102-ILE125
R	GLU167-SER183
R	GLN184-THR198
S	GLU83-PRO101
S	LYS102-ILE125
S	GLU167-SER183
S	GLN184-THR198
T	GLU83-PRO101
T	LYS102-ILE125
T	GLU167-SER183
B	GLN184-THR198
T	GLN184-THR198
U	GLU83-PRO101
U	LYS102-ILE125
U	GLU167-SER183
U	GLN184-THR198
V	GLU83-PRO101
V	LYS102-ILE125
V	GLU167-SER183
V	GLN184-THR198
W	GLU83-PRO101
C	GLU83-PRO101
W	LYS102-ILE125
W	GLU167-SER183
W	GLN184-THR198
X	GLU83-PRO101
X	LYS102-ILE125
X	GLU167-SER183
X	GLN184-THR198

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	SITE: Cleavage; by CAPS3, CAPS6 and CAPS9 => ECO:0000305|PubMed:28154144

Chain	Residue	Details
A	ASP91
J	ASP91
K	ASP91
L	ASP91
M	ASP91
N	ASP91
O	ASP91
P	ASP91
Q	ASP91
R	ASP91
S	ASP91
B	ASP91
T	ASP91
U	ASP91
V	ASP91
W	ASP91
X	ASP91
C	ASP91
D	ASP91
E	ASP91
F	ASP91
G	ASP91
H	ASP91
I	ASP91

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	SITE: Cleavage; by ELANE => ECO:0000269|PubMed:36899106

Chain	Residue	Details
A	MET220
J	MET220
K	MET220
L	MET220
M	MET220
N	MET220
O	MET220
P	MET220
Q	MET220
R	MET220
S	MET220
B	MET220
T	MET220
U	MET220
V	MET220
W	MET220
X	MET220
C	MET220
D	MET220
E	MET220
F	MET220
G	MET220
H	MET220
I	MET220

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	SITE: Cleavage; by granzyme A => ECO:0000269|PubMed:32299851

Chain	Residue	Details
A	LYS233
E	ASN248
F	LYS233
F	ASN248
G	LYS233
G	ASN248
H	LYS233
H	ASN248
I	LYS233
I	ASN248
J	LYS233
A	ASN248
J	ASN248
K	LYS233
K	ASN248
L	LYS233
L	ASN248
M	LYS233
M	ASN248
N	LYS233
N	ASN248
O	LYS233
B	LYS233
O	ASN248
P	LYS233
P	ASN248
Q	LYS233
Q	ASN248
R	LYS233
R	ASN248
S	LYS233
S	ASN248
T	LYS233
B	ASN248
T	ASN248
U	LYS233
U	ASN248
V	LYS233
V	ASN248
W	LYS233
W	ASN248
X	LYS233
X	ASN248
C	LYS233
C	ASN248
D	LYS233
D	ASN248
E	LYS233

---

site_id	SWS_FT_FI5
Number of Residues	96
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36991122

Chain	Residue	Details
A	LYS177
C	LYS190
C	LYS192
D	LYS177
D	LYS190
D	LYS192
E	LYS177
E	LYS190
E	LYS192
F	LYS177
F	LYS190
F	LYS192
G	LYS177
G	LYS190
G	LYS192
H	LYS177
A	LYS190
H	LYS190
H	LYS192
I	LYS177
I	LYS190
I	LYS192
J	LYS177
J	LYS190
A	LYS192
J	LYS192
K	LYS177
K	LYS190
K	LYS192
L	LYS177
L	LYS190
L	LYS192
M	LYS177
B	LYS177
M	LYS190
M	LYS192
N	LYS177
N	LYS190
N	LYS192
O	LYS177
O	LYS190
O	LYS192
P	LYS177
P	LYS190
P	LYS192
Q	LYS177
Q	LYS190
Q	LYS192
R	LYS177
B	LYS190
R	LYS190
R	LYS192
S	LYS177
S	LYS190
S	LYS192
T	LYS177
T	LYS190
B	LYS192
T	LYS192
U	LYS177
U	LYS190
U	LYS192
V	LYS177
V	LYS190
V	LYS192
W	LYS177
C	LYS177
W	LYS190
W	LYS192
X	LYS177
X	LYS190
X	LYS192

---