8ESZ

Structure of mitochondrial complex I from Drosophila melanogaster, Helix-locked state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005739	cellular_component	mitochondrion
1	0005743	cellular_component	mitochondrial inner membrane
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0016020	cellular_component	membrane
1	1902600	biological_process	proton transmembrane transport
2	0005739	cellular_component	mitochondrion
2	0005743	cellular_component	mitochondrial inner membrane
2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
2	0045271	cellular_component	respiratory chain complex I
2	1902600	biological_process	proton transmembrane transport
3	0005739	cellular_component	mitochondrion
3	0005743	cellular_component	mitochondrial inner membrane
3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0031966	cellular_component	mitochondrial membrane
3	0045271	cellular_component	respiratory chain complex I
3	1902600	biological_process	proton transmembrane transport
4	0005739	cellular_component	mitochondrion
4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4	0016020	cellular_component	membrane
4	0031966	cellular_component	mitochondrial membrane
4	0042773	biological_process	ATP synthesis coupled electron transport
4	1902600	biological_process	proton transmembrane transport
4L	0005739	cellular_component	mitochondrion
4L	0005743	cellular_component	mitochondrial inner membrane
4L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
4L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4L	0016020	cellular_component	membrane
4L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4L	0031966	cellular_component	mitochondrial membrane
4L	0042773	biological_process	ATP synthesis coupled electron transport
4L	0045271	cellular_component	respiratory chain complex I
4L	1902600	biological_process	proton transmembrane transport
5	0005739	cellular_component	mitochondrion
5	0005743	cellular_component	mitochondrial inner membrane
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0042773	biological_process	ATP synthesis coupled electron transport
5	1902600	biological_process	proton transmembrane transport
6	0005739	cellular_component	mitochondrion
6	0005743	cellular_component	mitochondrial inner membrane
6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0016020	cellular_component	membrane
6	0031966	cellular_component	mitochondrial membrane
6	0045271	cellular_component	respiratory chain complex I
6	1902600	biological_process	proton transmembrane transport
A1	0003674	molecular_function	molecular_function
A1	0005739	cellular_component	mitochondrion
A1	0005743	cellular_component	mitochondrial inner membrane
A1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A1	0008150	biological_process	biological_process
A1	0045271	cellular_component	respiratory chain complex I
A3	0005737	cellular_component	cytoplasm
A3	0005739	cellular_component	mitochondrion
A3	0005743	cellular_component	mitochondrial inner membrane
A3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A3	0030017	cellular_component	sarcomere
A3	0030018	cellular_component	Z disc
A3	0045271	cellular_component	respiratory chain complex I
A5	0005739	cellular_component	mitochondrion
A5	0005743	cellular_component	mitochondrial inner membrane
A5	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A5	0022904	biological_process	respiratory electron transport chain
A5	0045271	cellular_component	respiratory chain complex I
A6	0005739	cellular_component	mitochondrion
A6	0005743	cellular_component	mitochondrial inner membrane
A6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A6	0006979	biological_process	response to oxidative stress
A6	0016491	molecular_function	oxidoreductase activity
A6	0032981	biological_process	mitochondrial respiratory chain complex I assembly
A6	0045271	cellular_component	respiratory chain complex I
A7	0005743	cellular_component	mitochondrial inner membrane
A7	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A7	0016020	cellular_component	membrane
A7	0016491	molecular_function	oxidoreductase activity
A7	0042773	biological_process	ATP synthesis coupled electron transport
A7	0045271	cellular_component	respiratory chain complex I
A8	0005739	cellular_component	mitochondrion
A8	0005743	cellular_component	mitochondrial inner membrane
A8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A8	0016491	molecular_function	oxidoreductase activity
A8	0032981	biological_process	mitochondrial respiratory chain complex I assembly
A8	0045271	cellular_component	respiratory chain complex I
A9	0005739	cellular_component	mitochondrion
A9	0005743	cellular_component	mitochondrial inner membrane
A9	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A9	0032981	biological_process	mitochondrial respiratory chain complex I assembly
A9	0044877	molecular_function	protein-containing complex binding
A9	0045271	cellular_component	respiratory chain complex I
A9	1901006	biological_process	ubiquinone-6 biosynthetic process
AB	0000035	molecular_function	acyl binding
AB	0000036	molecular_function	acyl carrier activity
AB	0005739	cellular_component	mitochondrion
AB	0005743	cellular_component	mitochondrial inner membrane
AB	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AB	0006633	biological_process	fatty acid biosynthetic process
AB	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AB	0045271	cellular_component	respiratory chain complex I
AB	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
AB	1902494	cellular_component	catalytic complex
AC	0000035	molecular_function	acyl binding
AC	0000036	molecular_function	acyl carrier activity
AC	0005739	cellular_component	mitochondrion
AC	0005743	cellular_component	mitochondrial inner membrane
AC	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AC	0006633	biological_process	fatty acid biosynthetic process
AC	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AC	0045271	cellular_component	respiratory chain complex I
AC	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
AC	1902494	cellular_component	catalytic complex
AL	0005515	molecular_function	protein binding
AL	0005737	cellular_component	cytoplasm
AL	0005739	cellular_component	mitochondrion
AL	0005743	cellular_component	mitochondrial inner membrane
AL	0005759	cellular_component	mitochondrial matrix
AL	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AL	0045271	cellular_component	respiratory chain complex I
AM	0003674	molecular_function	molecular_function
AM	0005739	cellular_component	mitochondrion
AM	0005743	cellular_component	mitochondrial inner membrane
AM	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AM	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AM	0045271	cellular_component	respiratory chain complex I
AN	0005739	cellular_component	mitochondrion
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AN	0006979	biological_process	response to oxidative stress
AN	0016020	cellular_component	membrane
AN	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AN	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
AN	0045271	cellular_component	respiratory chain complex I
AO	0005739	cellular_component	mitochondrion
AO	0005743	cellular_component	mitochondrial inner membrane
AO	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AO	0016020	cellular_component	membrane
AO	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AO	0045271	cellular_component	respiratory chain complex I
B1	0005739	cellular_component	mitochondrion
B1	0005743	cellular_component	mitochondrial inner membrane
B1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B1	0016491	molecular_function	oxidoreductase activity
B1	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B1	0045271	cellular_component	respiratory chain complex I
B2	0003674	molecular_function	molecular_function
B2	0005739	cellular_component	mitochondrion
B2	0005743	cellular_component	mitochondrial inner membrane
B2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B2	0008150	biological_process	biological_process
B2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B2	0045271	cellular_component	respiratory chain complex I
B3	0005739	cellular_component	mitochondrion
B3	0005743	cellular_component	mitochondrial inner membrane
B3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B3	0016491	molecular_function	oxidoreductase activity
B3	0022900	biological_process	electron transport chain
B3	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B3	0045271	cellular_component	respiratory chain complex I
B4	0005739	cellular_component	mitochondrion
B4	0005743	cellular_component	mitochondrial inner membrane
B4	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B4	0016020	cellular_component	membrane
B4	0016491	molecular_function	oxidoreductase activity
B4	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B4	0045271	cellular_component	respiratory chain complex I
B5	0000302	biological_process	response to reactive oxygen species
B5	0005739	cellular_component	mitochondrion
B5	0005743	cellular_component	mitochondrial inner membrane
B5	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B5	0008340	biological_process	determination of adult lifespan
B5	0016020	cellular_component	membrane
B5	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B5	0045271	cellular_component	respiratory chain complex I
B6	0005743	cellular_component	mitochondrial inner membrane
B6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B6	0045271	cellular_component	respiratory chain complex I
B7	0005739	cellular_component	mitochondrion
B7	0005743	cellular_component	mitochondrial inner membrane
B7	0005758	cellular_component	mitochondrial intermembrane space
B7	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B7	0016020	cellular_component	membrane
B7	0016491	molecular_function	oxidoreductase activity
B7	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B7	0045271	cellular_component	respiratory chain complex I
B8	0005739	cellular_component	mitochondrion
B8	0005743	cellular_component	mitochondrial inner membrane
B8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B8	0016491	molecular_function	oxidoreductase activity
B8	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B8	0045271	cellular_component	respiratory chain complex I
B9	0005739	cellular_component	mitochondrion
B9	0005743	cellular_component	mitochondrial inner membrane
B9	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B9	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B9	0045271	cellular_component	respiratory chain complex I
BL	0005739	cellular_component	mitochondrion
BL	0005743	cellular_component	mitochondrial inner membrane
BL	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
BL	0045271	cellular_component	respiratory chain complex I
BM	0003674	molecular_function	molecular_function
BM	0005743	cellular_component	mitochondrial inner membrane
BM	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BM	0016020	cellular_component	membrane
BM	0022904	biological_process	respiratory electron transport chain
BM	0045271	cellular_component	respiratory chain complex I
C2	0005739	cellular_component	mitochondrion
C2	0005743	cellular_component	mitochondrial inner membrane
C2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
C2	0045271	cellular_component	respiratory chain complex I
S1	0005739	cellular_component	mitochondrion
S1	0005743	cellular_component	mitochondrial inner membrane
S1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S1	0016020	cellular_component	membrane
S1	0016491	molecular_function	oxidoreductase activity
S1	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S1	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S1	0042773	biological_process	ATP synthesis coupled electron transport
S1	0045271	cellular_component	respiratory chain complex I
S1	0045333	biological_process	cellular respiration
S1	0046872	molecular_function	metal ion binding
S1	0051536	molecular_function	iron-sulfur cluster binding
S1	0051537	molecular_function	2 iron, 2 sulfur cluster binding
S1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S1	0072593	biological_process	reactive oxygen species metabolic process
S1	1902600	biological_process	proton transmembrane transport
S2	0003954	molecular_function	NADH dehydrogenase activity
S2	0005739	cellular_component	mitochondrion
S2	0005743	cellular_component	mitochondrial inner membrane
S2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S2	0016491	molecular_function	oxidoreductase activity
S2	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S2	0045271	cellular_component	respiratory chain complex I
S2	0048038	molecular_function	quinone binding
S2	0051287	molecular_function	NAD binding
S2	1902600	biological_process	proton transmembrane transport
S3	0005515	molecular_function	protein binding
S3	0005739	cellular_component	mitochondrion
S3	0005743	cellular_component	mitochondrial inner membrane
S3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S3	0016491	molecular_function	oxidoreductase activity
S3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S3	0045271	cellular_component	respiratory chain complex I
S3	0072593	biological_process	reactive oxygen species metabolic process
S3	1902600	biological_process	proton transmembrane transport
S4	0005739	cellular_component	mitochondrion
S4	0005743	cellular_component	mitochondrial inner membrane
S4	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S4	0022900	biological_process	electron transport chain
S4	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S4	0045271	cellular_component	respiratory chain complex I
S5	0005743	cellular_component	mitochondrial inner membrane
S5	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S5	0045271	cellular_component	respiratory chain complex I
S6	0005739	cellular_component	mitochondrion
S6	0005743	cellular_component	mitochondrial inner membrane
S6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S6	0022904	biological_process	respiratory electron transport chain
S6	0045271	cellular_component	respiratory chain complex I
S7	0000302	biological_process	response to reactive oxygen species
S7	0003954	molecular_function	NADH dehydrogenase activity
S7	0005743	cellular_component	mitochondrial inner membrane
S7	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S7	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S7	0008340	biological_process	determination of adult lifespan
S7	0009060	biological_process	aerobic respiration
S7	0015990	biological_process	electron transport coupled proton transport
S7	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S7	0045271	cellular_component	respiratory chain complex I
S7	0046872	molecular_function	metal ion binding
S7	0048038	molecular_function	quinone binding
S7	0051536	molecular_function	iron-sulfur cluster binding
S7	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S7	2000331	biological_process	regulation of terminal button organization
S8	0003954	molecular_function	NADH dehydrogenase activity
S8	0005739	cellular_component	mitochondrion
S8	0005743	cellular_component	mitochondrial inner membrane
S8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S8	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S8	0016020	cellular_component	membrane
S8	0016491	molecular_function	oxidoreductase activity
S8	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S8	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S8	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
S8	0045271	cellular_component	respiratory chain complex I
S8	0046872	molecular_function	metal ion binding
S8	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S8	1902600	biological_process	proton transmembrane transport
V1	0005739	cellular_component	mitochondrion
V1	0005743	cellular_component	mitochondrial inner membrane
V1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
V1	0010181	molecular_function	FMN binding
V1	0045271	cellular_component	respiratory chain complex I
V1	0046872	molecular_function	metal ion binding
V1	0051287	molecular_function	NAD binding
V1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V1	1902600	biological_process	proton transmembrane transport
V2	0003954	molecular_function	NADH dehydrogenase activity
V2	0005515	molecular_function	protein binding
V2	0005739	cellular_component	mitochondrion
V2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
V2	0016491	molecular_function	oxidoreductase activity
V2	0045271	cellular_component	respiratory chain complex I
V2	0046872	molecular_function	metal ion binding
V2	0051537	molecular_function	2 iron, 2 sulfur cluster binding
V2	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
S8	CYS118-PRO129
S8	CYS157-PRO168

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
S2	LEU121-LYS132

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMYgvffanHpdlRrIL

Chain	Residue	Details
S3	GLU169-LEU190

---

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TISKSIGGGA

Chain	Residue	Details
S1	THR676-ALA685

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlavaGnCRmC

Chain	Residue	Details
S1	PRO71-CYS88

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
S1	CYS138-GLN150

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
S1	ARG189-PHE199

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
V1	GLY215-SER230

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
V1	GLU392-GLY403

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GIPQpFcDAIKLFtKE

Chain	Residue	Details
1	GLY51-GLU66

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDFAEGEseLVs.G

Chain	Residue	Details
1	PRO204-GLY217

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DrkFTiseveCLGaCvnAP

Chain	Residue	Details
V2	ASP159-PRO177

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIIPVDIYvPgCPP

Chain	Residue	Details
S7	GLY177-PRO193

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
3	ILE4-ILE24
3	ILE60-ILE80
3	ILE86-HIS106
6	PHE143-THR163
2	ILE146-LEU166
2	SER195-PHE215
2	PHE238-PRO258
2	PHE273-CYS293
2	MET321-PHE341

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01184

Chain	Residue	Details
S1	HIS134
S1	CYS138
S1	CYS141
S1	CYS147

---