Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ES9

CryoEM structure of PN45428 TCR-CD3 in complex with HLA-A2 MAGEA4

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0007166	biological_process	cell surface receptor signaling pathway
D	0016020	cellular_component	membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0007166	biological_process	cell surface receptor signaling pathway
E	0016020	cellular_component	membrane
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0007166	biological_process	cell surface receptor signaling pathway
F	0016020	cellular_component	membrane
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0007166	biological_process	cell surface receptor signaling pathway
G	0016020	cellular_component	membrane
M	0000139	cellular_component	Golgi membrane
M	0002376	biological_process	immune system process
M	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
M	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
M	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
M	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
M	0002715	biological_process	regulation of natural killer cell mediated immunity
M	0002726	biological_process	positive regulation of T cell cytokine production
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005765	cellular_component	lysosomal membrane
M	0005783	cellular_component	endoplasmic reticulum
M	0005788	cellular_component	endoplasmic reticulum lumen
M	0005794	cellular_component	Golgi apparatus
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006955	biological_process	immune response
M	0007608	biological_process	sensory perception of smell
M	0007611	biological_process	learning or memory
M	0009897	cellular_component	external side of plasma membrane
M	0009986	cellular_component	cell surface
M	0010038	biological_process	response to metal ion
M	0012507	cellular_component	ER to Golgi transport vesicle membrane
M	0016020	cellular_component	membrane
M	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
M	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
M	0023026	molecular_function	MHC class II protein complex binding
M	0030670	cellular_component	phagocytic vesicle membrane
M	0031901	cellular_component	early endosome membrane
M	0031902	cellular_component	late endosome membrane
M	0031905	cellular_component	early endosome lumen
M	0033572	biological_process	transferrin transport
M	0034756	biological_process	regulation of iron ion transport
M	0034757	biological_process	negative regulation of iron ion transport
M	0035580	cellular_component	specific granule lumen
M	0042605	molecular_function	peptide antigen binding
M	0042612	cellular_component	MHC class I protein complex
M	0042613	cellular_component	MHC class II protein complex
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0042824	cellular_component	MHC class I peptide loading complex
M	0048260	biological_process	positive regulation of receptor-mediated endocytosis
M	0048261	biological_process	negative regulation of receptor-mediated endocytosis
M	0050680	biological_process	negative regulation of epithelial cell proliferation
M	0050768	biological_process	negative regulation of neurogenesis
M	0050778	biological_process	positive regulation of immune response
M	0050870	biological_process	positive regulation of T cell activation
M	0051289	biological_process	protein homotetramerization
M	0055038	cellular_component	recycling endosome membrane
M	0070062	cellular_component	extracellular exosome
M	0071281	biological_process	cellular response to iron ion
M	0071316	biological_process	cellular response to nicotine
M	1904724	cellular_component	tertiary granule lumen
M	1990000	biological_process	amyloid fibril formation
M	1990712	cellular_component	HFE-transferrin receptor complex
M	2000774	biological_process	positive regulation of cellular senescence
M	2000978	biological_process	negative regulation of forebrain neuron differentiation
Y	0004888	molecular_function	transmembrane signaling receptor activity
Y	0007166	biological_process	cell surface receptor signaling pathway
Y	0016020	cellular_component	membrane
Z	0004888	molecular_function	transmembrane signaling receptor activity
Z	0007166	biological_process	cell surface receptor signaling pathway
Z	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
M	TYR78-HIS84
N	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	184
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	130
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	57
Details	Domain: {"description":"Ig-like"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8636209","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	88
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)