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8EQV

Cryo-EM structure of PRC2 in complex with the long isoform of AEBP2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006260biological_processDNA replication
A0006325biological_processchromatin organization
A0006334biological_processnucleosome assembly
A0006335biological_processDNA replication-dependent chromatin assembly
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0007420biological_processbrain development
A0008094molecular_functionATP-dependent activity, acting on DNA
A0008285biological_processnegative regulation of cell population proliferation
A0016581cellular_componentNuRD complex
A0016589cellular_componentNURF complex
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031492molecular_functionnucleosomal DNA binding
A0032991cellular_componentprotein-containing complex
A0033186cellular_componentCAF-1 complex
A0035098cellular_componentESC/E(Z) complex
A0042393molecular_functionhistone binding
A0042659biological_processregulation of cell fate specification
A0042826molecular_functionhistone deacetylase binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0070822cellular_componentSin3-type complex
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A1904949cellular_componentATPase complex
A2000736biological_processregulation of stem cell differentiation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0001222molecular_functiontranscription corepressor binding
B0001739cellular_componentsex chromatin
B0003682molecular_functionchromatin binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005677cellular_componentchromatin silencing complex
B0005730cellular_componentnucleolus
B0006325biological_processchromatin organization
B0008047molecular_functionenzyme activator activity
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0016586cellular_componentRSC-type complex
B0016604cellular_componentnuclear body
B0031490molecular_functionchromatin DNA binding
B0032993cellular_componentprotein-DNA complex
B0035064molecular_functionmethylated histone binding
B0035098cellular_componentESC/E(Z) complex
B0043565molecular_functionsequence-specific DNA binding
B0045596biological_processnegative regulation of cell differentiation
B0046872molecular_functionmetal ion binding
B0048709biological_processoligodendrocyte differentiation
B0060816biological_processrandom inactivation of X chromosome
B0106222molecular_functionlncRNA binding
B0140718biological_processfacultative heterochromatin formation
B1990841molecular_functionpromoter-specific chromatin binding
B1990904cellular_componentribonucleoprotein complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000785cellular_componentchromatin
C0003677molecular_functionDNA binding
C0003712molecular_functiontranscription coregulator activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006325biological_processchromatin organization
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0035098cellular_componentESC/E(Z) complex
C0046872molecular_functionmetal ion binding
D0000082biological_processG1/S transition of mitotic cell cycle
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0000976molecular_functiontranscription cis-regulatory region binding
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
D0001222molecular_functiontranscription corepressor binding
D0003677molecular_functionDNA binding
D0003682molecular_functionchromatin binding
D0003714molecular_functiontranscription corepressor activity
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005677cellular_componentchromatin silencing complex
D0005694cellular_componentchromosome
D0005721cellular_componentpericentric heterochromatin
D0006325biological_processchromatin organization
D0006346biological_processDNA methylation-dependent heterochromatin formation
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0008168molecular_functionmethyltransferase activity
D0008284biological_processpositive regulation of cell population proliferation
D0009913biological_processepidermal cell differentiation
D0010468biological_processregulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0014013biological_processregulation of gliogenesis
D0014834biological_processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
D0014898biological_processcardiac muscle hypertrophy in response to stress
D0016279molecular_functionprotein-lysine N-methyltransferase activity
D0021695biological_processcerebellar cortex development
D0021766biological_processhippocampus development
D0030097biological_processhemopoiesis
D0030183biological_processB cell differentiation
D0030216biological_processkeratinocyte differentiation
D0030335biological_processpositive regulation of cell migration
D0031048biological_processregulatory ncRNA-mediated heterochromatin formation
D0031490molecular_functionchromatin DNA binding
D0031491molecular_functionnucleosome binding
D0031507biological_processheterochromatin formation
D0031509biological_processsubtelomeric heterochromatin formation
D0032259biological_processmethylation
D0032355biological_processresponse to estradiol
D0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
D0035098cellular_componentESC/E(Z) complex
D0035984biological_processcellular response to trichostatin A
D0036211biological_processprotein modification process
D0036333biological_processhepatocyte homeostasis
D0042054molecular_functionhistone methyltransferase activity
D0042127biological_processregulation of cell population proliferation
D0042393molecular_functionhistone binding
D0042752biological_processregulation of circadian rhythm
D0043021molecular_functionribonucleoprotein complex binding
D0043406biological_processpositive regulation of MAP kinase activity
D0043547biological_processpositive regulation of GTPase activity
D0043565molecular_functionsequence-specific DNA binding
D0045120cellular_componentpronucleus
D0045202cellular_componentsynapse
D0045605biological_processnegative regulation of epidermal cell differentiation
D0045617biological_processnegative regulation of keratinocyte differentiation
D0045814biological_processnegative regulation of gene expression, epigenetic
D0045892biological_processnegative regulation of DNA-templated transcription
D0046976molecular_functionhistone H3K27 methyltransferase activity
D0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
D0048511biological_processrhythmic process
D0048863biological_processstem cell differentiation
D0050767biological_processregulation of neurogenesis
D0051154biological_processnegative regulation of striated muscle cell differentiation
D0051932biological_processsynaptic transmission, GABAergic
D0070301biological_processcellular response to hydrogen peroxide
D0070314biological_processG1 to G0 transition
D0070878molecular_functionprimary miRNA binding
D0071168biological_processprotein localization to chromatin
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0090183biological_processregulation of kidney development
D0097421biological_processliver regeneration
D0106222molecular_functionlncRNA binding
D0140718biological_processfacultative heterochromatin formation
D0140938molecular_functionhistone H3 methyltransferase activity
D0140951molecular_functionhistone H3K27 trimethyltransferase activity
D1900006biological_processpositive regulation of dendrite development
D1900016biological_processnegative regulation of cytokine production involved in inflammatory response
D1902808biological_processpositive regulation of cell cycle G1/S phase transition
D1904772biological_processresponse to tetrachloromethane
D1990841molecular_functionpromoter-specific chromatin binding
D2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
D2000737biological_processnegative regulation of stem cell differentiation
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001222molecular_functiontranscription corepressor binding
E0003682molecular_functionchromatin binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005829cellular_componentcytosol
E0006325biological_processchromatin organization
E0008047molecular_functionenzyme activator activity
E0021510biological_processspinal cord development
E0031491molecular_functionnucleosome binding
E0031507biological_processheterochromatin formation
E0035098cellular_componentESC/E(Z) complex
E0042802molecular_functionidentical protein binding
E0045892biological_processnegative regulation of DNA-templated transcription
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues24
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H
ChainResidueDetails
CCYS263-HIS286
CCYS330-HIS352
BCYS450-HIS471

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
ALEU193-ILE207
ALEU289-LEU303
ALEU333-LEU347
ELEU206-ILE220

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues23
DetailsZN_FING: C2H2-type
ChainResidueDetails
BLEU448-HIS471

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Breakpoint for translocation to form JAZF1-SUZ12 oncogene
ChainResidueDetails
BPRO93
DSER363

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER20
BSER541
BSER726

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER546
ELYS197
ELYS268
ELYS284

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336
ChainResidueDetails
BSER583
CSER24

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:18628979
ChainResidueDetails
BLYS72
BLYS73

site_idSWS_FT_FI7
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DTHR487
BLYS223
BLYS390

site_idSWS_FT_FI8
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS75
CSER211

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS634

225946

PDB entries from 2024-10-09

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