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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8EQV

Cryo-EM structure of PRC2 in complex with the long isoform of AEBP2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006325biological_processchromatin organization
A0006334biological_processnucleosome assembly
A0006335biological_processDNA replication-dependent chromatin assembly
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0007420biological_processbrain development
A0008094molecular_functionATP-dependent activity, acting on DNA
A0008285biological_processnegative regulation of cell population proliferation
A0016581cellular_componentNuRD complex
A0016589cellular_componentNURF complex
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031492molecular_functionnucleosomal DNA binding
A0031507biological_processheterochromatin formation
A0032991cellular_componentprotein-containing complex
A0033186cellular_componentCAF-1 complex
A0035098cellular_componentESC/E(Z) complex
A0042393molecular_functionhistone binding
A0042659biological_processregulation of cell fate specification
A0042826molecular_functionhistone deacetylase binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0070822cellular_componentSin3-type complex
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A2000736biological_processregulation of stem cell differentiation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0001222molecular_functiontranscription corepressor binding
B0001739cellular_componentsex chromatin
B0003682molecular_functionchromatin binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005677cellular_componentchromatin silencing complex
B0005730cellular_componentnucleolus
B0006325biological_processchromatin organization
B0006351biological_processDNA-templated transcription
B0008047molecular_functionenzyme activator activity
B0008270molecular_functionzinc ion binding
B0016586cellular_componentRSC-type complex
B0016604cellular_componentnuclear body
B0031490molecular_functionchromatin DNA binding
B0031507biological_processheterochromatin formation
B0031519cellular_componentPcG protein complex
B0032993cellular_componentprotein-DNA complex
B0035098cellular_componentESC/E(Z) complex
B0043565molecular_functionsequence-specific DNA binding
B0045596biological_processnegative regulation of cell differentiation
B0046872molecular_functionmetal ion binding
B0062072molecular_functionhistone H3K9me2/3 reader activity
B0106222molecular_functionlncRNA binding
B0140718biological_processfacultative heterochromatin formation
B1990841molecular_functionpromoter-specific chromatin binding
B1990904cellular_componentribonucleoprotein complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000785cellular_componentchromatin
C0003677molecular_functionDNA binding
C0003712molecular_functiontranscription coregulator activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006325biological_processchromatin organization
C0006351biological_processDNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0008270molecular_functionzinc ion binding
C0031507biological_processheterochromatin formation
C0035098cellular_componentESC/E(Z) complex
C0046872molecular_functionmetal ion binding
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0000792cellular_componentheterochromatin
D0000976molecular_functiontranscription cis-regulatory region binding
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
D0001222molecular_functiontranscription corepressor binding
D0003677molecular_functionDNA binding
D0003682molecular_functionchromatin binding
D0003714molecular_functiontranscription corepressor activity
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005677cellular_componentchromatin silencing complex
D0005694cellular_componentchromosome
D0005721cellular_componentpericentric heterochromatin
D0006325biological_processchromatin organization
D0006338biological_processchromatin remodeling
D0006351biological_processDNA-templated transcription
D0006355biological_processregulation of DNA-templated transcription
D0008168molecular_functionmethyltransferase activity
D0008284biological_processpositive regulation of cell population proliferation
D0010629biological_processnegative regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0016279molecular_functionprotein-lysine N-methyltransferase activity
D0016740molecular_functiontransferase activity
D0021766biological_processhippocampus development
D0030183biological_processB cell differentiation
D0030335biological_processpositive regulation of cell migration
D0031048biological_processregulatory ncRNA-mediated heterochromatin formation
D0031490molecular_functionchromatin DNA binding
D0031491molecular_functionnucleosome binding
D0031507biological_processheterochromatin formation
D0031509biological_processsubtelomeric heterochromatin formation
D0031519cellular_componentPcG protein complex
D0032259biological_processmethylation
D0032355biological_processresponse to estradiol
D0035098cellular_componentESC/E(Z) complex
D0042054molecular_functionhistone methyltransferase activity
D0042393molecular_functionhistone binding
D0042752biological_processregulation of circadian rhythm
D0043021molecular_functionribonucleoprotein complex binding
D0043406biological_processpositive regulation of MAP kinase activity
D0043547biological_processpositive regulation of GTPase activity
D0043565molecular_functionsequence-specific DNA binding
D0045120cellular_componentpronucleus
D0045202cellular_componentsynapse
D0045814biological_processnegative regulation of gene expression, epigenetic
D0045892biological_processnegative regulation of DNA-templated transcription
D0046976molecular_functionhistone H3K27 methyltransferase activity
D0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
D0048468biological_processcell development
D0048511biological_processrhythmic process
D0051932biological_processsynaptic transmission, GABAergic
D0070878molecular_functionprimary miRNA binding
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0090183biological_processregulation of kidney development
D0106222molecular_functionlncRNA binding
D0140718biological_processfacultative heterochromatin formation
D0140938molecular_functionhistone H3 methyltransferase activity
D0140951molecular_functionhistone H3K27 trimethyltransferase activity
D1900006biological_processpositive regulation of dendrite development
D1900016biological_processnegative regulation of cytokine production involved in inflammatory response
D1902808biological_processpositive regulation of cell cycle G1/S phase transition
D1990841molecular_functionpromoter-specific chromatin binding
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001222molecular_functiontranscription corepressor binding
E0001739cellular_componentsex chromatin
E0003682molecular_functionchromatin binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005677cellular_componentchromatin silencing complex
E0005694cellular_componentchromosome
E0006325biological_processchromatin organization
E0006351biological_processDNA-templated transcription
E0008047molecular_functionenzyme activator activity
E0021510biological_processspinal cord development
E0031491molecular_functionnucleosome binding
E0031507biological_processheterochromatin formation
E0035098cellular_componentESC/E(Z) complex
E0042802molecular_functionidentical protein binding
E0045120cellular_componentpronucleus
E0045892biological_processnegative regulation of DNA-templated transcription
E0140718biological_processfacultative heterochromatin formation
E1990841molecular_functionpromoter-specific chromatin binding
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues24
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H
ChainResidueDetails
CCYS263-HIS286
CCYS330-HIS352
BCYS450-HIS471
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
ELEU206-ILE220
ALEU193-ILE207
ALEU289-LEU303
ALEU333-LEU347
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues49
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues47
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues45
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues56
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues32
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60972","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues71
DetailsRegion: {"description":"Interaction with SUZ12","evidences":[{"source":"PubMed","id":"29499137","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues43
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues43
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues40
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues41
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues37
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues40
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues33
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues360
DetailsRegion: {"description":"Interaction with EZH2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues294
DetailsRegion: {"description":"Required for interaction with the matrix protein MA of HIV-1"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues3
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues29
DetailsRegion: {"description":"Interaction with EED","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues23
DetailsZinc finger: {"description":"C2H2-type"}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues76
DetailsRegion: {"description":"VEFS-box"}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsSite: {"description":"Breakpoint for translocation to form JAZF1-SUZ12 oncogene"}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

250359

PDB entries from 2026-03-11

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