8EK8
Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGGAGAAGGG)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 166 |
| Details | DNA binding: {"description":"ETS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00237","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence","evidences":[{"source":"UniProtKB","id":"P17433","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"contacts bases in the GGAA sequence in the major groove","evidences":[{"source":"UniProtKB","id":"P17433","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"contacts the phosphate backbone of the GGAA sequence in the minor groove upstream","evidences":[{"source":"UniProtKB","id":"P17433","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
