8EK8
Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGGAGAAGGG)
Functional Information from GO Data
Chain | GOid | namespace | contents |
E | 0003700 | molecular_function | DNA-binding transcription factor activity |
E | 0006355 | biological_process | regulation of DNA-templated transcription |
E | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
E | 0043565 | molecular_function | sequence-specific DNA binding |
F | 0003700 | molecular_function | DNA-binding transcription factor activity |
F | 0006355 | biological_process | regulation of DNA-templated transcription |
F | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 166 |
Details | DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237 |
Chain | Residue | Details |
F | ILE170-SER253 | |
E | ILE170-SER253 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence => ECO:0000250|UniProtKB:P17433 |
Chain | Residue | Details |
F | LYS217 | |
E | LYS217 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: contacts bases in the GGAA sequence in the major groove => ECO:0000250|UniProtKB:P17433 |
Chain | Residue | Details |
F | ARG230 | |
F | ARG233 | |
E | ARG230 | |
E | ARG233 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: contacts the phosphate backbone of the GGAA sequence in the minor groove upstream => ECO:0000250|UniProtKB:P17433 |
Chain | Residue | Details |
F | LYS243 | |
E | LYS243 |