8EIR

SARS-CoV-2 polyprotein substrate regulates the stepwise Mpro cleavage reaction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing
B	0008233	molecular_function	peptidase activity
B	0019082	biological_process	viral protein processing
C	0003723	molecular_function	RNA binding
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0008270	molecular_function	zinc ion binding
C	0016740	molecular_function	transferase activity
C	0019079	biological_process	viral genome replication
D	0003723	molecular_function	RNA binding
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0008270	molecular_function	zinc ion binding
D	0016740	molecular_function	transferase activity
D	0019079	biological_process	viral genome replication

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01297

Chain	Residue	Details
C	CYS81
D	CYS84
D	HIS90
D	CYS97
D	CYS124
D	CYS127
D	CYS135
D	CYS137
C	CYS84
C	HIS90
C	CYS97
C	CYS124
C	CYS127
C	CYS135
C	CYS137
D	CYS81

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
C	GLN-304
C	GLN-106
C	GLN7
C	GLN146
D	GLN-304
D	GLN-106
D	GLN7
D	GLN146

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
A	GLN306
B	GLN306

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