8EDN

Cryo-EM structure of the full-length human NF1 dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0001649	biological_process	osteoblast differentiation
A	0001656	biological_process	metanephros development
A	0001666	biological_process	response to hypoxia
A	0001889	biological_process	liver development
A	0001937	biological_process	negative regulation of endothelial cell proliferation
A	0001952	biological_process	regulation of cell-matrix adhesion
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007154	biological_process	cell communication
A	0007265	biological_process	Ras protein signal transduction
A	0007406	biological_process	negative regulation of neuroblast proliferation
A	0007420	biological_process	brain development
A	0007422	biological_process	peripheral nervous system development
A	0007507	biological_process	heart development
A	0008289	molecular_function	lipid binding
A	0008429	molecular_function	phosphatidylethanolamine binding
A	0008542	biological_process	visual learning
A	0014044	biological_process	Schwann cell development
A	0016020	cellular_component	membrane
A	0021510	biological_process	spinal cord development
A	0021897	biological_process	forebrain astrocyte development
A	0021987	biological_process	cerebral cortex development
A	0022011	biological_process	myelination in peripheral nervous system
A	0030036	biological_process	actin cytoskeleton organization
A	0030198	biological_process	extracellular matrix organization
A	0030199	biological_process	collagen fibril organization
A	0030325	biological_process	adrenal gland development
A	0030336	biological_process	negative regulation of cell migration
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031210	molecular_function	phosphatidylcholine binding
A	0042060	biological_process	wound healing
A	0043065	biological_process	positive regulation of apoptotic process
A	0043087	biological_process	regulation of GTPase activity
A	0043409	biological_process	negative regulation of MAPK cascade
A	0043473	biological_process	pigmentation
A	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0043535	biological_process	regulation of blood vessel endothelial cell migration
A	0043547	biological_process	positive regulation of GTPase activity
A	0045124	biological_process	regulation of bone resorption
A	0045685	biological_process	regulation of glial cell differentiation
A	0045765	biological_process	regulation of angiogenesis
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0048485	biological_process	sympathetic nervous system development
A	0048593	biological_process	camera-type eye morphogenesis
A	0048715	biological_process	negative regulation of oligodendrocyte differentiation
A	0048745	biological_process	smooth muscle tissue development
A	0048844	biological_process	artery morphogenesis
A	0048853	biological_process	forebrain morphogenesis
A	0050793	biological_process	regulation of developmental process
A	0050890	biological_process	cognition
A	0098978	cellular_component	glutamatergic synapse
A	0099175	biological_process	regulation of postsynapse organization
A	1902531	biological_process	regulation of intracellular signal transduction

Functional Information from PROSITE/UniProt

site_id	PS00509
Number of Residues	15
Details	RAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins (rasGAP) domain signature. SaMFLRFINPAIVSP

Chain	Residue	Details
A	SER1386-PRO1400

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