8ECG

Complex of HMG1 with pitavastatin

Replaces:  7ULM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004420	molecular_function	hydroxymethylglutaryl-CoA reductase (NADPH) activity
A	0008299	biological_process	isoprenoid biosynthetic process
A	0015936	biological_process	coenzyme A metabolic process
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Functional Information from PROSITE/UniProt

site_id	PS00066
Number of Residues	15
Details	HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. RfCCsTGDaMGmNmV

Chain	Residue	Details
A	ARG352-VAL366

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site_id	PS00318
Number of Residues	8
Details	HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGtVGGGT

Chain	Residue	Details
A	VAL507-THR514

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site_id	PS01192
Number of Residues	14
Details	HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. AIaAgqLvRSHMkY

Chain	Residue	Details
A	ALA561-TYR574

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
A	GLU265
A	LYS397
A	ASP473

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10003

Chain	Residue	Details
A	HIS571

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10318703, ECO:0000269|PubMed:28263378, ECO:0000269|PubMed:7588795

Chain	Residue	Details
A	SER577

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN329
A	ASN575

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