8E6V

MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001659	biological_process	temperature homeostasis
A	0002407	biological_process	dendritic cell chemotaxis
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005384	molecular_function	manganese ion transmembrane transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006816	biological_process	calcium ion transport
A	0009408	biological_process	response to heat
A	0014074	biological_process	response to purine-containing compound
A	0015278	molecular_function	intracellularly gated calcium channel activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019722	biological_process	calcium-mediated signaling
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035579	cellular_component	specific granule membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0042995	cellular_component	cell projection
A	0043204	cellular_component	perikaryon
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0047631	molecular_function	ADP-ribose diphosphatase activity
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051289	biological_process	protein homotetramerization
A	0051489	biological_process	regulation of filopodium assembly
A	0055085	biological_process	transmembrane transport
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070588	biological_process	calcium ion transmembrane transport
A	0070821	cellular_component	tertiary granule membrane
A	0071277	biological_process	cellular response to calcium ion
A	0071421	biological_process	manganese ion transmembrane transport
A	0071502	biological_process	cellular response to temperature stimulus
A	0071577	biological_process	zinc ion transmembrane transport
A	0072571	molecular_function	mono-ADP-D-ribose binding
A	0097028	biological_process	dendritic cell differentiation
A	0097553	biological_process	calcium ion transmembrane import into cytosol
A	0098703	biological_process	calcium ion import across plasma membrane
A	0099604	molecular_function	ligand-gated calcium channel activity
A	0101003	cellular_component	ficolin-1-rich granule membrane

Functional Information from PROSITE/UniProt

site_id	PS01095
Number of Residues	9
Details	GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. IDGVNFNpE

Chain	Residue	Details
A	ILE986-GLU994

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PUS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---