8E6V
MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement)
Functional Information from PROSITE/UniProt
| site_id | PS01095 |
| Number of Residues | 9 |
| Details | GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. IDGVNFNpE |
| Chain | Residue | Details |
| A | ILE986-GLU994 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1243 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-GLY752 | |
| A | LEU770-PRO795 | |
| A | TYR849-PHE867 | |
| A | LYS918-ARG929 | |
| A | ILE1045-ALA1079 | |
| A | LEU1099-TYR1503 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:30467180 |
| Chain | Residue | Details |
| A | LEU753-GLY769 | |
| A | ALA1080-VAL1098 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 121 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30467180 |
| Chain | Residue | Details |
| A | VAL796-VAL816 | |
| A | CYS828-PHE848 | |
| A | TRP868-ILE888 | |
| A | VAL897-SER917 | |
| A | MET930-VAL950 | |
| A | TRP1023-LEU1044 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | LEU817-TRP827 | |
| A | PRO889-ARG896 | |
| A | ALA951-ALA970 | |
| A | ILE986-GLU1022 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:30467180 |
| Chain | Residue | Details |
| A | VAL971-TYR985 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:30467180 |
| Chain | Residue | Details |
| A | GLU843 | |
| A | GLN846 | |
| A | ASN869 | |
| A | GLU1073 |
